Obésité et diabète de type 2 - L`Université Paris Descartes

Obésité'et'diabète'de'type'2':'des' cellules'au'carrefour'du'microbiote'et'de'
l’inflammation'?'
Des' chercheurs' de' l’Institut' Cochin' (CNRS/Inserm/Université' Paris' Descartes)' et' de'
l’Institut'de'cardiométabolisme'et'nutrition'–'ICAN'(Inserm/UPMC/APJHP)'ont' découvert'
qu’une' classe' de' cellules' inflammatoires,' les' lymphocytes' MAIT1,' est' dérégulée' chez' les'
patients' atteints' de' diabète' de' type' 2' et' d’obésité.' Chez' ces' derniers,' la' chirurgie'
bariatrique' (ou' !"#$%%'gastrique)2,' qui' soulage' l’inflammation,' rétablit' aussi' le'
fonctionnement'normal'des'cellules'MAIT.'Déjà'connues'pour'être'activées'par'certaines'
populations'bactériennes'et'pour'favoriser'l’inflammation,'ces'cellules'pourraient'faire'le'
lien' entre' la' modification' de' la' flore' intestinale' (microbiote)' observée' chez' les' patients'
atteints'd’obésité'et'de'diabète'de'type'2,'et'le'caractère'inflammatoire'de'ces'maladies.'
Ces'travaux'sont'publiés'le'9'mars'2015'dans'la'revue'&'()*$+,'-,.+/*/0$+,1*23%4/5$4/'*.'
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Bibliographie'
MucosalJassociated' invariant' T' cell' alterations' in' obese' and' type' 2' diabetic' patientsB! L2&'#..#!
J&5&.4&#2B! V&7%3#! S%357%2B! ?47%2)%3#! S0%)0:B! Z)1+4&3%#! ]#220.#2B! Y%<0.&2! ^#3)#<.#EB! ]&$7! V%&EB! ":<%#!
]#&:$0%3B! _#33%E#7! R&! Z%.6&B! I87&3! K..&)%EB! _&8%#! \022P043B! "&72! VP#7TY%#.2#3B! _&8#2! J<?.:2Q#*B!
Z16#7%3#! "#$0:@B! "&:7#3)! `#32#7B! K$7%&3&! H07<%6%&B! ?.&%7#! Z0:$&%2B! I.%6%#7! "&3)MB! ?47%2)%&3! ]0%)&7$B!
_:$%)4! K703Ta%23#b2Q*B! G)%#33#! "&75#7B! V&7%3#! ?.18#3)! #)! K53(2! "#4:#3>! The) Journal) of) Clinical)
InvestigationB!c!8&72!,de[>!!
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