VTA
dopamine
Zona
incerta
Pons
granule
parallel CS
Hippocampus episodic memory
Dentate Gyrus CA3 CA1 subiculum
Parahippocampal
Intralaminar
(to layer 1)
Hypothalamus
Chiasmatic N
PPt (Ach)
Motor
Olive
climbing
US
Facial
nucleus
Sup Colliculus
Inf Colliculus
LGN
Pulvinar
V1 V2
Amygdala
DL FEF
OF PremotorMF
Association
cortex,
Accumbens
Cerebellar
cortex
Ventral pallidum
Cerebellar
nuclei
Red
nuclus
Striatum
Matr/Stri
Gross
motor
postural
GPi
GPe
subthal
SNc
dopamine
VL VPL CM PF
VA/VL
MDi
mid
Pontine
reticular
formation
MB
Anterior
thalamus
PP
PAG
MDl
Habenula/
pineal
Fine
motor
Attention
orienting
movement
Rhythmic
movement
autonomic
Pituitary
SMN
vision
MG
auditory
Papez circuit
distribution from
hippocampus
Inter-
peduncular
Sensory
cortex
recognition
Frontal
cortex
action plan
A1
Medial Septum
(ACh/GABA
Audiitory
SNr
cingulate
NR
AA1
AA2
AA3
TP
IT
Insula
PP
SS1
VPL
SMG
SA
PP
A1, primary auditory; AA1-3, auditory associational; GP, globus palidus
(internal/externall); IT, infero-temporal;FEF, frontal eye field; Mf, medial
frontal, M1, primary motor, M2 secondary motor; MB, mammilary body; NR,
nucleus reuinions; OF, orbito-frontal;PAG, periaqueductal grey; PPt,
pedunculo-pontine; PP, posterior parietal; SA, somatosensory associational;
SNc, substantia nigra compacta; SNr, substantia nigra reticulata; SMG,
supra-marginal gyrus (face area); SMN, supramammillary body;subthal,
subtahalamic nucleus; TP, temporal pole; VTA, ventral tegmental area;
somatosensory
cingulate
wherewhatwhy
3 to 4/3
5 to 1
6
5
Light
grey
boxes
are
thalamic
nuclei
A2
SS2
Long range
cortical pathways
Basal Ganglia
action selection
Cerebellum
timing
Major Brain Regions and Their Major Interconnections
Color code of
output to
frontal cortex
Hipp-VTA
loop
Inhibitory
Attentional system
Long-range cortico-
cortico tracts
Sensory input
Lisman,2005
claustrum
Spinal
somatosensory
vestibular
MDm
mid
Green
structures
are limbic