Les innovations technologiques: principal levier vers une médecine 4P Philippe A. COUCKE Médecine 4P ? • • • • P = Prédictive P = Préventive P = Personnalisée P = Participative Medicine for the common good, is not good enough … Personalized & Participative ==> 4P’s Personalized medicine: Time for one-person trials Nicholas J. Schork 29 April 2015 Nature / Comment Precision medicine requires a different type of clinical trial that focuses on individual, not average, responses to therapy, says Nicholas J. Schork. Precision Medicine Initiative (2015) Evolution vers une médecine 4P •Préventive •Prédictive •Participative •Personnalisée Precision Medicine Spreading Among US Hospitals Ken Terry September 07, 2016 MEDSCAPE Nearly a third of healthcare organizations are engaged in some kind of precision medicine research, according to a recent survey that focused on larger hospitals and healthcare systems. The survey defined precision medicine as "an approach for disease treatment and prevention that takes into account individual variability in genes, environment and lifestyle for each person." Pourquoi changer ? Les 4 chiffres clés de la médecine Quality & Safety in Health Care 50 – 35 – 10 - 5 On a toujours fait comme cela ! L’innovation disruptive ? L’accélération de l’innovation disruptive Schumpeter studied and adapted this long wave curve in his book ‘Business Cycles’ (1939), proposing each curve would not be uniformly shaped, lasting around 50 years, but as time passed each curve would get shorter, and also the complexity of the innovation would increase. 4ème Révolution Industrielle WEF Klaus Schwab Fondateur Forum de Davos Numérique Robotique Internet Industriel Automatisation Biotechnologies Cette 4ème Révolution industrielle est Inéluctable / Indispensable Innovations technologiques disruptives • • • • Le patient: un « objet » connecté. Le changement de paradigme: eHealth La force du « big data » L’organisation des soins Aujourd’hui il ne faut plus se poser la question si le domaine de la santé sera « disrupté » mais quand le sera-t-il? Le patient un « objet » connecté Mobile Health Le patient connecté • • • • Mesure ponctuelle Mesure en continu Du « wearable » au « forgettable » Les « wearables » intelligents Reports: 559.6M wearables, 87M activity trackers will ship in 2021 March 08, 2016 MOBIHEALTHNEWS “While fitness is the overwhelming driver for wearables today, there are a number of micro-segments emerging, ranging from kids’ watches to smart footwear to new healthcare devices like wearable patches, that will drive this market forward.” Life style Wellness Instant ECG. 50% off AliveCor Heart Monitor + free ground shipping = $99.50. Kardia ECG Band for Apple Watch Unveiled MARCH 16TH, 2016 MEDGADGET AliveCor, makers of popular smartphone powered ECG devices, has unveiled an ECG band for the Apple Watch. The Kardia band still needs to be cleared by the FDA before going on sale, but the firm promises clinical grade results that may help patients identify arrhythmias with assistance from their physicians. As you record the ECG by placing a finger over the electrode, the app lets you record a voice memo stating any symptoms you’re feeling and any exigent circumstances you’re in that may be causing issues. These are saved next to the ECG chart and can be replayed at any time. Business Card with a Built-in Electrocardiograph MARCH 2ND, 2016 MEDGADGET & DIGITALTRENDS.COM The developers of MobilECG, an upcoming open source electrocardiography system, are gearing up with pretty cool business cards any cardiologist would be jealous of. The team’s business card crams a one lead ECG, including the digital display and battery, into the smallest package we’ve ever seen. It’s technically not a diagnostic device, having not received any regulatory approvals. Nevertheless, we’re confident the technology inside works just like any simple ECG device. Wing, Sparo Lab's FDA-cleared, app-connected lung function monitor, now available to consumers By Heather MackNovember 21, 2016 MOBIHEALTHNEWS.COM Wing is a pocket-sized spirometer with a cloud-connected companion app that measures and tracks lung function, ultimately aiming to reassure parents of children with asthma and help them proactively manage the condition. The sensor and app work to measure the fastest speed and maximum volume a person can exhale in one second (forced exhalation and peak flow volume), and the results are displayed on the smartphone screen with a “stoplight zone” system, displaying a green, yellow or red indicator and an explanation of how the lungs are doing in that particular moment. SpiroCall Puts a Spirometer Inside Any Mobile Phone to Measure Lung Function MAY 3RD, 2016 MEDGADGET Luckily, researchers at the University of Washington have developed a way of using just about any phone, not just smartphones, to fairly accurately measure lung function. L’examen clinique Mesure ponctuelle versus mesure en continu • Contact médecin - patient = <10 heures/an • Contact maladie – patient = 8760 heures Qui est réellement l’expert? Cardiogram gets $2M to see if the Apple Watch can detect Afib By Jonah Comstock October 20, 2016 MOBIHEALTHNEWS Cardiogram has been working with UCSF since March to collect user data in a study called mRhythm and use it to develop an app for detecting atrial fibrillation based on on Apple Watch data. Sensimed receives FDA clearance for Triggerfish, connected contact lens that tracks glaucoma progression By Aditi Pai March 28, 2016 MOBIHEALTHNEWS Switzerland-based Sensimed announced it received a de novo FDA clearance for its connected contact lens, Triggerfish, which helps physicians track the progression of glaucoma in patients. Triggerfish is a sensor-embedded contact lens that will record continuous ocular dimensional changes for 24 hours. The data is sent from the lens wirelessly to a recorder that users wear around their neck. After the recording period has ended, the data is transferred from the recorder to a physician’s computer via Bluetooth -- meaning the patient needs to return to the physician's office to upload it. Checkme Pro “Medical Tricorder” Green Lit by FDA DECEMBER 14TH, 2015 MEDGADGET The Checkme Pro portable health monitor from Viatom Technology, a company out of Shenzhen, China, has been cleared by the FDA. The device performs one-lead ECG recording, pulse oximetry, temperature measurement, and movement sensing. There’s also cuffless systolic blood pressure measurement that relies on calibration, but this part has not been included in the U.S. version. Holst Centre Introduces Next Generation Health Patch NOVEMBER 18TH, 2016 MEDGADGET The health patch is equipped with multiple sensing capabilities. It incorporates an accelerometer to monitor physical activity, ECG technology to record cardiac electrical activity, and is also able to track body temperature, respiratory rate, and body composition. All of this critical data will be transferred to the user’s mobile device using wireless Bluetooth technology, and can be easily shared with the user’s healthcare provider for immediate review. Also, the wireless nature of the patch allows users to move freely and without restrictions while continuously being monitored. Introducing The Battery-Free Electronic “Skin Patch” That Can Monitor Your Health August 5th 2016 FUTURISM / San Diego Jacobs School of Engineering Rogers says, “we believe that these systems represent the next generation of wearable technology, where thin, skin-like devices can interface with the body to provide clinically relevant data on health status.” Medgadget @ CES 2016: Profusa Unveils Long-Term Implantable Biosensor January 12th, 2016 Profusa showed off an upcoming injectable sensor that can be used to continuously monitor oxygen levels in tissue. An optical reader placed on the skin measures the fluorescence and relays the data to a smartphone. The biosensor can last as long as two years Senseonics receives CE Mark for implantable continuous glucose monitoring system By Aditi Pai May 11, 2016 MOBIHEALTHNEWS Senseonics, a Germantown, Maryland-based company working on a longterm implantable continuous glucose monitor, has received a CE Mark for its Eversense Continuous Glucose Monitoring (CGM) System. L’observance thérapeutique On estime que 90 % des personnes atteintes de maladies chroniques seraient non observantes à un moment ou un autre de leur traitement. Les effets d’une mauvaise observance thérapeutique se traduisent par : des conséquences médicales : accroissement des risques de complications liées à la pathologie. des conséquences économiques et sociales : plus d’un million de journées d’hospitalisation et près de huit milles décès par an, et un coût de 2 milliards d’euros pour l’assurance maladie. Tricella Pillbox Gives Smarts to Old-fashioned Drug Container MARCH 16TH, 2016 MEDGADGET The Tricella app monitors which pills were taken and when, comparing those events to the pre-defined schedule that the person should be following. Any misses or mistakes, such as opening the wrong chamber, will warn the user or any family member whose info is added within the app. The system will soon be available on Amazon and Target for about $75. Proteus Swallowable Smart Pills FDA Approved to Measure Medication Adherence July 6th, 2015 MEDGADGET The underlying technology has been approved by the FDA since 2012, but the ability to accurately record when every pill was swallowed has only now been FDA-sanctioned to be used to measure medication adherence. The patch then uses its built-in Bluetooth antenna to share when every pill was swallowed with the matching smartphone app, which in turn passes the readings to family, caretakers, and the patient’s physician. Texas hospital testing Proteus's ingestible sensor with pediatric organ transplant patients By Jonah Comstock August 22, 2016 MOBIHEALTHNEWS Proteus Digital Health is working with Children's Health in Dallas, Texas in one of the first trials of its ingestible sensor technology in pediatric patients, The Dallas Morning News reports. The trial involves patients recovering from an organ transplant, a group that typically needs to take a lot of medications on a fairly strict schedule. Fifteen patients are using the Proteus platform now and Children's Dallas ultimately intends to enroll 75. Major step for implantable drug-delivery device MIT spinout signs deal to commercialize microchips that release therapeutics inside the body. Rob Matheson | MIT News Office June 29, 2015 An implantable, microchip-based device may soon replace the injections and pills now needed to treat chronic diseases Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world’s largest producer of generic drugs, to treat specific diseases, with licensing potential for other products. While its first partnership is for treating chronic diseases, Microchips Biotech will continue work on its flagship product, a birth-control microchip, backed by the Bill and Melinda Gates Foundation, that releases contraceptives and can be turned on and off wirelessly. Les « wearables » intelligents Study: Smartphone app that listens to breathing, determines respiratory diseases is 89 percent accurate ! April 4th 2016 MOBIHEALTHNEWS A smartphone-based system for diagnosing respiratory diseases achieved an accuracy of 89 percent in a recent clinical study of 524 pediatric patients conducted by the company at Joondalup Health Campus (JHC) and Princess Margaret Hospital (PMH) in Perth, Western Australia. For the differential diagnosis of croup, viral pneumonia, bronchiolitis and upper respiratory tract infections ResApp’s algorithms achieved accuracy levels between 90 and 98 percent. Voice Used as Diagnostic Biomarker for Coronary Artery Disease NOVEMBER 15TH, 2016 MEDGADGET Beyond Verbal, a company that provides voice analysis software, has announced that its algorithms were used successfully to help detect the presence of coronary artery disease (CAD) in a group of patients. Results of a study conducted at the Mayo Clinic show that voice can be used as a biomarker for CAD Vitals set includes: Blood pressure Electrocardiography (heart rate) Body temperature Respiratory rate Oxygen saturation Disease set includes: Anemia Urinary tract infection, lower Diabetes, type 2 Atrial fibrillation Stroke Sleep apnea, obstructive Chronic obstructive pulmonary disease (COPD) Otitis ("ear infection") Leukocytosis Hepatitis A Absence of conditions Mononucleosis Strep throat Pneumonia HIV screen Tuberculosis The World’s First “Artificial Pancreas” Will Be Hitting the Market in 2017 September 29th 2016 FUTURISM The MiniMed 670G is the first device to combine an automated glucose monitor and an insulin pump. It could help the more than 1.25 million American children and adults with type 1 diabetes manage their disease. Scientists Created Smart Contacts That Can Monitor and Treat Diabetes June 6th 2016 FUTURISM.COM Researchers from the Pohang University of Science and Technology in Korea (POSTECH) found a new way to monitor diabetes and deliver medication…through a smart contact lens-eyeglass combo. The Military Is Making Implants That Monitor The Health of Soldiers in Combat July 22nd 2016 / IOT Newsletter Profusa’s vision is to replace a point-in-time chemistry panel that measures multiple biomarkers, such as oxygen, glucose, lactate, urea, and ions with a biosensor that provides a continuous stream of wireless data The Defense Advanced Research Projects Agency (DARPA) and the U.S. Army Research Office gave a $7.5 million grant to biotech company Profusa, to further develop its implantable biosensors that will continue monitoring multiple body chemistries. Multiples problèmes à résoudre… Le challenge de l’intégration Le challenge de la réglementation Le challenge de la validité Health and medical app landscape becoming crowded, harder to monetize, report finds By Heather MackOctober 11, 2016 MOBIHEALTHNEWS In the land of digital health apps, space is becoming limited. According to a new study by Research 2 Guidance, the number of health and medical apps is still surging – 259,000 such apps were listed on major app stores in 2016 – but downloads are starting to slow down, indicating an increasingly crowded and competitive market. Unified Microchip for Processing Multiple Body Signals OCTOBER 6TH, 2016 MEDGADGET A collaboration between IMEC of Belgium and Holst Centre in The Netherlands: a new integrated systemon-a-chip that can accept and process data coming from a variety of body monitoring devices. It can natively accept a three channel analog ECG signal, convert it into digital, and perform signal processing all within the single chip. The full list of channels the chip can process is three ECG channels, photoplethysmography (PPG), galvanic skin response (GSR), two multi-frequency bio-impedance (BIO-Z) channels for newly applied technologies such as impedance-tomography, body fluid analysis, and stroke volume measurements. New Efficient Techniques for Health Monitoring Using Multiple Wearables NOVEMBER 18TH, 2016 MEDGADGET.COM Researchers at North Carolina State University have been working on making sure that such sensors only transmit important readings and organize these readings within data structures that will provide the most utility to clinicians. Their approach is to continuously classify different states that the wearer is in, whether it be walking, running, or sitting, and to then transmit only data that doesn’t seem to fit what the person seems to be doing. The team will be presenting their research titled “Hierarchical Activity Clustering Analysis for Robust Graphical Structure Recovery,” at the 2016 IEEE Global Conference on Signal and Information Processing, Dec. 7-9 in Washington, D.C. Cohero Health raises $9M for integrated, connected approach to chronic respiratory disease By Jonah Comstock November 02, 2016 MOBIHEALTHNEWS i Cohero Health argues that their ntegrated approach, which includes controller medication, rescue medication, and a spirometer for measuring lung function, sets them apart from competition in the smart inhaler space. Catalysts that are really driving adoption: 1.Shifting reimbursement models that are really allowing for adoption of these kinds of continuous monitoring technologies, 2.Adoption of smartphone-based technologies that can be the hub of these disparate sources of biometric data, 3.Interoperability.” AliveCor Now Combines ECG, Omron’s BP Data In Single App SEPTEMBER 12TH, 2016 MEDGADGET Dr. David Albert, Founder and Chief Medical Officer at AliveCor, in a statement. “With this combined data, patients can change their most important modifiable risk factor, blood pressure, and seek the right care that could improve heart health and prevent a stroke. Today we are one step closer to achieving our mission of making the ECG a vital statistic for not just cardiologists, but patients, physicians and caregivers.” AliveCor is Expanding The Role That Mobile Applications Play in Cardiac Care NOVEMBER 15TH, 2016 MEDGADGET We recently covered AliveCor’s inclusion of Omron blood pressure data in their Kardia mobile application (iOS/Android) and they are quickly expanding their offering by integrating weight and activity tracking. These metrics are modifiable risk factors for cardiac care and stroke prevention – this is likely only the tip of the iceberg for AliveCor. They are also working toward clearance of their Kardia Band which will deliver clinical-grade electrocardiography on the Apple Watch. Study tests accuracy of heart rate monitors in Apple Watch, Fitbit, Basis, and Mio Satish Misra, MD | October 13, 2016 iMEDICALAPPS In a recent study published in JAMA Cardiology, researchers from the Cleveland Clinic tested the accuracy of heart rate monitoring in several popular wearables including the Apple Watch, Fitbit Charge, Mio Alpha, and Basis Peak. Overall, it does serve as a useful reminder of the limitations of consumer health wearables that are worth considering if you’re going to incorporate them into recommendations for patients. New Generation PKG Watch for Tracking Movement Disorders FDA Cleared SEPTEMBER 22ND, 2016 MEDGADGET Global Kinetics Corporation won FDA clearance for its new, second generation PKG (Personal KinetiGraph) watch, a tool that can help monitor patients with movement disorders such as Parkinson’s and essential tremor. Big Data « Habit » - omics A PERSONALIZED NUTRITION COMPANY WILL USE YOUR DNA TO TELL YOU WHAT TO EAT IS A DIET BASED ON YOUR GENOME THE FUTURE OF NUTRITION? By Claire Maldarelli October 25, 2016 popular science “We have always taken a one size-fitsall approach to dieting, and most [dieters] try and fail,” says Alan Greene, a pediatrician and physicianadvisor to Habit. He says understanding the complexities of our biologies first and figuring out the blueprint that fits it best will lead to success in an industry that has most often failed. Campbell's Soup invests $32M in personalized nutrition startup Habit By Jonah Comstock October 26, 2016 MOBIHEALTHNEWS Data-driven personalized nutrition service Habit has raised $32 million in an investment from Campbell's Soup, according to a report in the Philadelphia Business Journal. Campbell's CEO Denise Morrison told the Journal the investment was "part of our broader efforts to define the future of food, which requires fresh thinking, new models of innovation, smart external development and venture investing to create an ecosystem of innovative partners." Big data … médicotechnique Watson to Gain Ability to “See” with Planned $1B Acquisition of Merge Healthcare Merge’s technology platforms are used at more than 7,500 U.S. healthcare sites. The vision is that these organizations could use the Watson Health Cloud to surface new insights from a consolidated, patient-centric view of current and historical images, electronic health records, data from wearable devices and other related medical data, in a HIPAA-enabled environment. CHICAGO - 06 Aug 2015: IBM Pigeons diagnose breast cancer on X-rays as well as radiologists When "flock-sourcing," they do better, with 99 percent accuracy --- and they work for seeds November 19, 2015 The pigeons were able to generalize what they had learned, so that when we showed them a completely new set of normal and cancerous digitized slides, they correctly identified them,” Levenson said. “The pigeons also learned to correctly identify cancer-relevant microcalcifications on mammograms Pigeons (Columba livia) as Trainable Observers of Pathology and Radiology Breast Cancer Images Published: November 18, 2015 DOI: 10.1371/journal.pone.0141357 Artificial Intelligence Reads Mammograms With 99% Accuracy September 25th 2016 FUTURISM A team from the Houston Methodist Research Institute says they have developed artificial intelligence software capable of analyzing mammograms for breast cancer with 99 percent accuracy. The technique involves scanning patient charts and cross-checking them with results from mammogram X-rays and clinical reports. “We figured out you can mine a clinical report for additional information,” said lead researcher Stephen Wong This Artificial Intelligence was 92% Accurate in Breast Cancer Detection Contest June 21st 2016 FUTURISM.COM Scientists trained an AI machine to detect breast cancer in images of lymph nodes. A group of researchers from Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS) have developed a way to train artificial intelligence to read and interpret pathology images. It turns out it can detect breast cancer accurately 92 percent of the time and won in two separate categories during the contest. Dossier Médical Informatisé IBM deal to buy Truven will add 8,500 clients and boost data trove to 300 million patients By Joseph Conn | February 18, 2016 Those Truven clients include hospitals, clinicians, health plans, employers, life science companies, and state and federal government agencies. Data brought over from the deal will also swell IBM's existing health-record data set to about 300 million patient lives In addition to the company's client list and its data, IBM will be getting one more valuable asset with the Truven acquisition—talent—from epidemiologists to consultants, creating a “dream team” that “will bring our global footprint of talent to 5,000 TECHNOLOGY NEWS 29 April 2016 Google AI has access to huge haul of NHS patient data The document – a data-sharing agreement between Google-owned artificial intelligence company DeepMind and the Royal Free NHS Trust – gives the clearest picture yet of what the company is doing and what sensitive data it now has access to. The agreement gives DeepMind access to a wide range of healthcare data on the 1.6 million patients who pass through three London hospitals run by the Royal Free NHS Trust – Barnet, Chase Farm and the Royal Free – each year. This will include information about people who are HIV-positive, for instance, as well as details of drug overdoses and abortions. The agreement also includes access to patient data from the last five years. IBM’s Watson AI Recommends Same Treatment as Doctors in 99% of Cancer Cases October 28th 2016 FUTURISM.COM Human experts at the University of North Carolina School of Medicine tested Watson by having the AI analyze 1,000 cancer diagnoses. In 99 percent of the cases, Watson was able to recommend treatment plans that matched actual suggestions from oncologists. Not only that, but because it can read and digest thousands of documents in minutes, Watson found treatment options human doctors missed in 30 percent of the cases. The AI’s processing power allowed it to take into account all of the research papers or clinical trials that the human oncologists might not have read at the time of diagnosis. Vous êtes inondés de données ? Big data en santé Big data en santé Partnership on AI: Tech Giants Unite to Develop Synthetic Intelligence for Humanity September 30th 2016 FUTURISM Consider it one of humanity’s first coalitions for the development of artificial intelligence. This week, tech bigwigs Google, Microsoft, and IBM are joined by Facebook and Amazon—teaming up to form the Partnership on Artificial Intelligence to Benefit People and Society. Le changement de l’organisation des soins Télésanté Des cabines de télémédecine dans les pharmacies 15/03/2016 Médiplanet / Libération Siège incliné, écran d'ordinateur pour guider le patient ou organiser une téléconsultation, instruments de mesures "pour peser, mesurer, calculer l'indice de masse corporelle, prendre la tension, le pouls, connaitre le taux d'oxygène dans le sang", mais aussi stéthoscope, dermatoscope, rétinographe, la cabine créée par la société française H4D (Health For Development), est présentée par ses promoteurs comme un véritable "petit cabinet médical connecté". PORTAL:TELEMEDICINE HEADSET ASSISTING REMOTE COMMUNICATION WITH YOUR DOCTOR BY B.J. MURPHY APRIL 24TH 2016 / SERIOUS WONDER Riding on top of this technological wave, designer Jonathan Stewart believes his concept design could help provide a more direct line of communication between doctors and their patients. Say hello to Portal – a telemedicine headset that will assist you with remote contact with any doctor you choose. The Portal telemedicine headset comes equipped with a detachable stethoscope, an integrated high definition eye camera, an ear pulse oximetry sensor, and a tympanic thermometer. This wearable device wouldn’t just provide your body’s basic vital data, but would also have the capability of integrating with subsequent data collected via other wearable devices. Chinese web company Baidu launches medical chatbot for doctors and patients By Heather Mack October 11, 2016 MOBIHEALTHNEWS Chinese search engine Baidu is introducing Melody, an AIpowered conversational bot. Melody gathers information, responds to patients about medical conditions and gives feedback to the real-life doctors. The service is available immediately in China. Patients can open the app and ask a question, and Melody will respond with context-relevant questions to clarify information such as symptom frequency or duration. USB Stick Measures HIV Levels Within Half Hour NOVEMBER 17TH, 2016 MEDGADGET.COM Researchers at Imperial College London and DNA Electronics, a company with offices in London, UK and Carlsbad, CA, developed a computer USB stick that takes a drop of blood and measures the amount of HIV particles. The chip produces results within 30 minutes, while the average in a test of nearly 1000 samples was only 21 minutes. HAD Hospitalisation à Domicile Patient of the Future New 'smart' tools will empower millions to diagnose and manage their condition at home. September 2nd 2015 USNews.com All of this data generated by smart, hyperconnected patients represents a serious challenge to medical paternalism. One of the NHS’ goals is to have 25% of chronic conditions like hypertension and diabetes monitoring their health remotely by 2020 UK NHS to spend nearly 6 billion$ to go digital including remote care & health apps February 12th 2016 iMedicalApps NHS to offer free devices and apps to help people manage illnesses June 17th 2016 The Guardian Millions of people will receive devices and apps free on the NHS to help them manage conditions such as diabetes and heart disease in an major drive to use technology to reduce patient deaths. A New Smartphone is Launching—And It’s Only $4 February 17th 2016 FUTURISM.COM The device is called Freedom 251 and was just very recently unveiled. Specs aside, the most impressive thing about the Freedom 251 is, by far, its price. The pricing strategy and development of the technology was anchored on Narendra Modi’s intent to ‘empower India to the last person Who needs beds? New ambulatory centers offer everything except inpatient care By David Royse | September 12, 2015 Modern Healthcare The Children's Hospital of Michigan Specialty Center, which opens in February, will have a 24-hour pediatric emergency room, operating rooms for a range of pediatric surgeries and outpatient care in several specialties… without inpatients beds Similarly, Montefiore Medical Center in New York opened a “bedless hospital” last year in the Bronx. The $152 million, 12floor, 280,000-square-foot tower features 12 operating rooms, exam rooms, a headache clinic, imaging facilities and, eventually, a full-service pharmacy—but no inpatient beds. Robots Could Be Performing a Third of U.S. Surgeries by 2021 August 3rd 2016 FUTURISM.COM As robotic surgery continues to grow, experts predict that, within the period of five years, robots will dominate the operating rooms in the United States. In fact, they could be conducting one of every three surgeries. CRISPR-Cas9: des ciseaux génétiques pour le cerveau 03.05.2016, par Léa Galanopoulo Journal CNRS First Human Tests of Memory Boosting Brain Implant—a Big Leap Forward By Shelly Fan Nov 15, 2015 Singularity Hub Memory loss seems to be inescapable. But one maverick neuroscientist is working hard on an electronic cure. Funded by DARPA, Dr. Theodore Berger, a biomedical engineer at the University of Southern California, is testing a memory-boosting implant that mimics the kind of signal processing that occurs when neurons are laying down new long-term memories. The revolutionary implant, already shown to help memory encoding in rats and monkeys, is now being tested in human patients with epilepsy — an exciting first that may blow the field of memory prosthetics wide open. Today patients ask their doctor. Tomorrow they may ask their data. Les 4 constats clés • • • • L’inefficience ubiquitaire du système actuel. La déferlante des technologies disruptives La transparence par les réseaux sociaux L’OPA par les GAFAMA et NATU sur les soins de santé (investissent massivement dans les NBIC). Quelles sont les plus-values apportées par l’E-Santé « aujourd’hui »? • Une médecine en continu (par rapport à une médecine ponctuelle). • Une approche quantitative multi-paramétrique. • Une approche Préventive plutôt que curative. • Une approche Prédictive (Precision Medicine Initiative) • Une approche Personnalisée & Participative. • Une accessibilité ubiquitaire. • Une efficience majorée. • Une amélioration de la compliance. Uber-Like Innovation Is Coming: Are Physicians Ready? March 04, 2016 MEDSCAPE.COM "Uber's message for health care is clear," they write. Providers have three choices: •Ignore innovators and hope for the best. •Call for increasing regulation to make it harder for innovators to enter the market. •Compete on quality and efficiency, disruptive though that might be. They suggest providers take the last option and hop on the innovation bus before it drives off without them. Principe de précaution Principe de pro-action • • • Le progrès est inévitable! • Les 5 principes: • • • • Manque d’objectivité. Oublie les risques majeurs liés à l’immobilisme! Ne prend pas en considération les intérêts de toutes les parties en cause; ignore le coût et les effets secondaires de la réglementation! Impose la charge de la preuve d’innocuité dès l’énoncé de « possibilités » de dégâts. Echec de compromis entre différents risques. Vulnérable à la corruption – Objectif, compréhensif structuré et explicite – Priorisation des différents risques • L’inaction est potentiellement aussi dangereuse que l’action – Inputs diversifiés (toutes les parties concernées). – Réponse (négative et restrictive) proportionnée aux risques (probabilité et sévérité). – Revoir et réévaluer. Hélas ! combien de temps faudra-t-il vous redire À vous tous, que c'était à vous de les conduire, Qu'il fallait leur donner leur part de la cité (savoir), Que votre aveuglement produit leur cécité (ignorance) ; D'une tutelle avare on recueille les suites, Et le mal qu'ils vous font, c'est vous qui le leur fîtes. Vous ne les avez pas guidés, pris par la main, Et renseignés sur l'ombre et sur le vrai chemin ; Vous les avez laissés en proie au labyrinthe. Ils sont votre épouvante et vous êtes leur crainte. Extrait de « A ceux qu’on foule aux pieds » Victor Hugo Le message positif ? Retour vers les vraies valeurs humaines! Empathie / Partage / Communication / Explication / Equilibre « écologique » / Développement durable