Switch - pilot intervention that targets motivational deficits in people with schizophrenia

Switch: pilot intervention that
targets motivational deficits
in people with schizophrenia Thonon, B.a*, Levaux, M.-N.b, Larøi, F.a,c,d
*[e-mail]
Background
__________________
Methods
____________
9 participants with schizophrenia / schizoaffective
disorder participated in Switch for 6 months. 7 of
them followed Switch for 12 months.
T0 T1 T2 T3
(6m, +-20 sessions) (12m, +-30 sessions) 18m
n=14 n=9 n=7
Assessement (T0-T3):
•Brief Negative Symptom Scale (BNSS) Amotivation subscale
•Functional Remission of General Schizophrenia (FROGS)
•Schizophrenia -Quality of Life scale (S-QOL)
Results and Discussion
______________________________
a Psychology and Neuroscience of Cognition Research Unit, Université de Liège, Belgium. b Intercommunale de Soins Spécialisés de Liège, Belgium. c Department of Biological and
Medical Psychology, University of Bergen, Norway. d NORMENT –Norwegian Center of Excellence for Mental Disorders Research, University of Oslo, Norway.
References and additional information: [e-mail]
=Best predictors (Fervaha et al., 2015)
=Resistant to pharmaceutical treatment
(Chue and Lalonde, 2014)
=Target of only afew interventions
(Lincoln and Pedersen, 2019)
ØGoal
____________
Difficulties in daily
functioning
Low quality of life
Negative
symptoms
Motivational
deficits
People with
schizophrenia
45’ / week
0-6 months
45’ / 2 weeks
6-9 months
45’ / 3-4 weeks
9-12 months - - - -
Develop +validate amultifactorial intervention
based on models of motivational deficits in
schizophrenia (Kring and Barch,2014;Rector et al., 2005)
1,5
2,0
2,5
3,0
3,5
4,0
0123
Paired sample t-tests
Comparing T1, T2, T3 to T0
Mean scores
BNSS Amotivation S-QOL FROGS M
*
* p< .10
** p< .05
**
**
•After 6months of Switch, significant and important reduction in
motivational deficits (d=-0.98,p=.02)and functional outcomes
(d-0.90,p=.04).
•After 12 months of Switch, significant and important reduction in
motivational deficits (d=-0.90,p=0.05). Moderate improvement
on functional outcomes, but statistically non-significant (d=0.42,
p=.30).
•6months after the end of Switch, moderate reduction in
motivational deficits (d=-0.50,p=.23)and functional outcomes
(d=0.66,p=.17), but statistically non-significant.
•Zero effect on reported quality of life.Secondary analyses:
improvement on satisfaction regarding family relationships.
ØModerate to moderately severe motivational negative
symptoms became light to moderate.Participants in Switch
showed more autonomy in their daily life after the intervention.
ØNeed to work on the maintenance of the improvement and the
impact on reported quality of life.