analgesicscreeeningmodel-150119013834-conversion-gate02

PHARMACOLOGICAL SCREENING OF
ANALGESIC AGENTS
Presented by :
CHAITRA. N
1st year M-Pharm
Dept.of Pharmacology
PESCP,Bangalore

CONTENTS
Introduction.
Mechanism of Action.
Classification.
Screening techniques.
In vivo.
In vitro.
References.

Pain is a complex unpleasant phenomenon composed
of sensory experiences that include time, space,
intensity, emotion, cognition and motivation.
An analgesic or painkiller is any member of the
group of drugs used to achieve analgesia —relief
from pain.
Analgesics is defined as the are agents which
selectively relieve pain by acting in the CNS or by
peripheral pain mechanisms without significantly
altering consciousness.
INTRODUCTION

Narcotics
Ex. Morphine, Pethadine,
Fentanyl
Non-narcotics
Ex. NSAID
Analgesics are classified as :
CLASSIFICATION

Analgesic drugs act in various ways on
the peripheral and central nervous systems.
Opioids produce analgesia by binding to specific
G –protein coupled receptors in brain and spinal
cord.
NSAIDs inhibit the activity of
both cyclooxygenase-1 (COX-1) and
cyclooxygenase-2 (COX-2) and thereby the
synthesis of prostaglandins and thromboxanes.
Inhibition of COX-2 leads to the anti-
MECHANISM OF ACTION