New concepts in diagnosis and management of iron deficiency
Telechargé par
balamane_mohamed
New concepts in diagnosis and
management of iron deficiency
Dr Jane KEIDAN
With thanks to
Vifor Pharma UK Ltd Rachael de Nobrega · Medical Advisor
Claire Atterbury
Mr Toby Richards
Outline
•Iron metabolism
•Treatment options
•Clinical use of intravenous iron-current and
developing areas
Total body iron: 2.5-4 grams
Mostly within the cardiovascular system, liver and muscles1:
Red blood cells 1.8 g
RES macrophages 0.6 g
Liver 1.0 g
Bone marrow 0.3 g
Muscles (myoglobin) 0.3 g
Other tissues 0.1 g
Bound to transport protein
Transferrin 0.003 g
Each ml of blood contains approximately 0.5 mg of iron
1. Hentze MW et al. Cell. 2004;117:285-97
Iron content of a balanced diet
•A balanced diet contains
5-6 mg of iron/1,000 kcal
•Recommended amount
of iron
–Adult man:
5-10 mg / day
–Adult woman:
7-20 mg / day
Iron in diet
•Richest sources of heme iron -lean meat , seafood.
Dietary sources of nonheme iron - nuts, beans,
vegetables, and fortified grain products.
•Heme iron has higher bioavailability than nonheme iron-
bioavailability 14- 18% from mixed diets that include
substantial amounts of meat/fish and 5% to 12% from
vegetarian diets
•Vitamin C enhances the bioavailability of nonheme iron
•Meat, poultry, and fish enhance nonheme iron
absorption, whereas phytate (present in grains and beans)
and certain polyphenols in some non-animal foods (such
as cereals and legumes) inhibit absorption
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