The Development of B lymphocytes
Chapter 6 Parham
Hans de Haard
21th of May 2010
Agenda
Stages in development of B cells
B cell development in bone marrow
Heavy chain rearrangement
Light chain rearrangement more efficient process
Checkpoints
B1 versus B2 lymphocytes
Removal self reactivity
B cell development in secondary lymphoid tissues
Differentiation into mature B lymphocytes
Maturation into plasma cells and memory cells
Various B cell tumors represent different stages in B cell development
Agenda
Stages in development of B cells
B cell development in bone marrow
Heavy chain rearrangement
Light chain rearrangement more efficient process
Checkpoints
B1 versus B2 lymphocytes
Removal self reactivity
B cell development in secondary lymphoid tissues
Differentiation into mature B lymphocytes
Maturation into plasma cells and memory cells
Various B cell tumors represent different stages in B cell development
Stages in development B cells
Phase 1: B cell precursors in bone marrow acquire
functional antigen receptors via gene rearrangements
Phase 2: elimination anti-self (tolerance) in bone
marrow and 2nd lymphoid tissues
Phase 3: positive selection for B cells expression of
pathogen specific Ig in 2nd lymphoid tissues
Phase 4: mature B cells circulate via lymph and blood
to lymphoid tissues patrolling for infections
Phase 5: proliferation and clonal expansion pathogen
specific B-cells in 2nd lymphoid tissues
Phase 6: maturation into:
plasma cells =>remain in 2nd lymphoid tissues, express large quantities
pathogen specific Ab
memory B cells (circulate) for rapid Ab generation in case of future
infections with same pathogen
Agenda
Stages in development of B cells
B cell development in bone marrow
Heavy chain rearrangement
Light chain rearrangement more efficient process
Checkpoints
B1 versus B2 lymphocytes
Removal self reactivity
B cell development in secondary lymphoid tissues
Differentiation into mature B lymphocytes
Maturation into plasma cells and memory cells
Various B cell tumors represent different stages in B cell development
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