Skip to content Centre de recherche de l'Institut Curie Research Center Search for: Donate fr en Research BIOLOGY & CHEMISTRY OF RADIATIONS, CELL SIGNALING AND CANCER BIOLOGY, CANCER, GENETICS AND EPIGENETICS INTEGRATIVE TUMOUR BIOLOGY, IMMUNOLOGY AND ENVIRONMENT MULTISCALE PHYSICS-BIOLOGY-CHEMISTRY AND CANCER DEPARTMENT OF TRANSLATIONAL RESEARCH SIRIC IPGG LABEX CELTISPHYBIO LABEX DEEP Platforms Bioinformatics platform BioPhenics Cell & Tissue Imaging Chemical Library Cytometry : cell sorting & analysis Experimental Radiotherapy Flow Cytometry Genomics In vivo experiments Mass Spectrometry and Proteomics Facility Next Generation Sequencing Pre-clinical investigation laboratory (LIP) Protein Expression and Purification Core Facility Reverse Phase Protein Array Synthetic Genetic Array (SGA) Therapeutic antibodies (Tab-IP) and recombinant antibodies Training Jobs About us All teams Biology & Chemistry of Radiations, Cell Signaling and Cancer UMR3348 - Genotoxic stress and Cancer Home Research Biology & Chemistry of Radiations, Cell Signaling and Cancer UMR3348 - Genotoxic stress and Cancer UMR3348 – Genotoxic stress and Cancer PARTAGER Presentation of the unitSeminarsInternational CoursesCommon ServicesUnit publications Unit DirectorMounira Amor-Guéret Unit Deputy DirectorStéphan Vagner The prevention of genomic instability and cancer depends on the optimal functions of a complex network of pathways collectively called the DNA damage response (DDR). The research activities of our unit span several aspects of the DDR, intracellular signalling and genome stability in response to genotoxic stress, either from endogenous sources (e.g. replication stress, mutations in oncogenes and tumor suppressor genes) or from exogenous sources (e.g. oxidative stress, chemotherapeutic agents, ionizing and UV radiation). We are particularly interested by the functional relationships between what we call the “6Rs”: Replication, Repair, Recombination, RNA biology, Redox regulation and responses to Radiations. We specifically want to focus on: The network of cellular responses to exogenous and endogenous stresses, The influence of cell stress responses on cancer susceptibility and treatment efficacy, The hijacking of stress-induced responses for the development of new anti-cancer therapies. The wide range of expertise of our teams in molecular and cellular biology, genetics and biochemistry allows us to address these issues by using a great variety of technological approaches and several model systems (yeast, mammalian cell lines, animal models). Key publications Year of publication 2017 Anissia Ait Saada, Ana Teixeira-Silva, Ismail Iraqui, Audrey Costes, Julien Hardy, Giulia Paoletti, Karine Fréon, Sarah A E Lambert (2017 May 4) Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges. Molecular cell : 398-410.e4 : DOI : 10.1016/j.molcel.2017.04.002 Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Christian Jaulin, Mounira AmorGuéret (2017 May 2) Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity. Cell cycle (Georgetown, Tex.) : 1-8 : DOI : 10.1080/15384101.2017.1317413 Hamza Mameri, Ivan Bieche, Dider Meseure, Elisabetta Marangoni, Géraldine Buhagiar-Labarchède, Andre Nicolas, Sophie Vacher, Rosine Onclercq-Delic, Vinodh Rajapakse, Sudhir Varma, William C Reinhold, Yves Pommier, Mounira Amor-Guéret (2017 Apr 15) Cytidine deaminase deficiency reveals new therapeutic opportunities against cancer. Clinical cancer research : an official journal of the American Association for Cancer Research : DOI : 10.1158/1078-0432.CCR-16-0626 Hermela Shimelis, Romy L S Mesman, Catharina Von Nicolai, Asa Ehlen, Lucia Guidugli, Charlotte Martin, Fabienne Mgr Calleja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M Aalfs, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W Beckmann, Javier J Benitez, Natalia Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Borresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Bruning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Ching-Yu Cheng, Ji-Yeob Choi, J Margriet Collée, Angela Cox, Simon S Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dork, Isabel Dos Santos Silva, Alison M Dunning, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Montserrat Garcia-Closas, Graham G Giles, Gord Glendon, Pascal Guenel, Christopher A Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli-Matti Kosma, Vessela Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Eva Machackova, Arto Mannermaa, Sara Margolin, Frederik Marme, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L Milne, Kenneth Muir, Susan L Neuhausen, Heli Nevanlinna, Janet E Olson, Curtis Olswold, Jan C Oosterwijk, Ana Osorio, Paolo Peterlongo, Julian Peto, Paul D P Pharoah, Katri Pylkäs, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Minouk J Schoemaker, Caroline M Seynaeve, Mitul Shah, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Susan L Slager, Melissa C Southey, Daniel O Stram, Anthony J Swerdlow, Soo Hwang Teo, Ian Tomlinson, Diana Torres, Therese Truong, Christi J van Asperen, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Anna H Wu, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan C Walker, Lenka Foretova, Florentia Fostira, Kathleen Claes, Liliana Varesco, Setareh Moghadasi, Douglas F Easton, Amanda B Spurdle, Peter Devilee, Harry Vrieling, Alvaro N Monteiro, David E Goldgar, Aura Carreira, Maaike P G Vreeswijk, Fergus J Couch (2017 Mar 10) BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer research : DOI : 10.1158/0008-5472.CAN-16-2568 Rocchetti F, Tran Quang C, Maragno AL, Nguyen J, Lasgi C, Ghysdael J. (2017 Jan 1) The calcineurin protein phosphatase is dispensable for BCR-ABL-induced B-ALL maintenance, propagation and response to dasatinib. Leukemia : DOI : 10.1038/leu.2016.269 Year of publication 2016 Michelle Newman, Rym Sfaxi, Abhijit Saha, David Monchaud, Marie-Paule Teulade-Fichou, Stéphan Vagner (2016 Dec 7) The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3′-End Processing Following UV-Induced DNA Damage. Journal of molecular biology : S0022-2836(16)30528-9 : DOI : 10.1016/j.jmb.2016.11.033 Presentation of the unit Seminars International Courses Common Services Unit publications News 11/05/2017 Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges DNA Recombination, Replication and Genome Stability (CNRS/Institut Curie) group, leaded by Sarah Lambert, published in Molecular Cell. Research reveals how stressed forks, unprotected by the recombination machinery, trigger mitotic defect and genome... 25/04/2017 BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Res. 2017 Mar 10. pii: canres.2568.2016. doi: 10.1158/0008-5472.CAN-16-2568. [Epub ahead of print] BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Shimelis H1, Mesman RL2, Von Nicolai C3, Ehlen A3,... Aura Carreira Médaille de bronze du CNRS 2017 Aura Carreira mène l’équipe Recombinaison Homologue et Cancer (CNRS/Université Paris-Sud/Institut Curie) dans les laboratoires d’Orsay du centre de recherche de l’institut Curie. La jeune scientifique a reçu la prestigieuse médaille de bronze... 16/09/2016 A novel DNA binding domain in BRCA2 with possible implications in breast cancer risk BRCA2 tumour suppressor protein has a recognized role in the repair of DNA double strand breaks by homologous recombination. The work of the Homologous Recombination and Cancer team describes a novel DNA... Teams Team Amor-Guéret Team Carreira Team Ghysdael Team Huang Team Janke Team Lambert Team Vagner EXPORTER LA PAGE EN PDF The sites of the Institut curie curie.fr protontherapie.curie.fr enseignement.curie.fr cancersdusein.curie.fr musee.curie.fr unejonquillepourcurie.fr radio.curie.fr Sitemap Contact Legals INSTITUT CURIE, 26 rue d’Ulm, 75248 Paris Cedex 05, France CENTRE DE RECHERCHE Paris +33 (0) 1 56 24 55 00 Orsay +33 (0) 1 69 86 30 00 Coming to the Institut Curie