Acción analgésica de la T.R.H. Daniel Palop Palop

Acción analgésica de la T.R.H.
Contribución al estudio de su mecanismo de acción.
Daniel Palop Palop
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ACCIÓN ANALGÉSICA DE LA TRH. CONTRIBUCIÓN AL
ESTUDIO DE SU MECANISMO DE ACCIÓN.
Tesis que presenta D. Daniel Palop y Palop,
Licenciado en Medicina y Cirugía, para optar
al grado de Doctor.
Facultad de Medicina
Universidad de Barcelona
Junio de 1982.
177
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( 1979 )
Neuromodulación aminêrgica y acción antinociceptiva de la morfina
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ARCH, de Farmacol y Toxicol V,
172 - 175
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( 1981 )
Intervención de mecanismos serotoninêrgicos en la actividad analgésica de la T.R.H.
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( 1976 )
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( 1975 )
Hemmung der pentagastrininduzierten säure Sekretion des magens beim
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Mechanisms of elevation of rat brain triptophan concentration by
various doses of salicylate.
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S.C. ( 1975 )
Differential sub-cellular compartmentalization of T.R.H. and Gonadotropin releasing hormone ( L.R.H. ) in hypothalamic tissue.
Proc Nat Acad Sei, U.S.A.
72,
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( 1972 )
Serum inactivation of the immunological and biological activity of
T.R.H.
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Regulation of degradation of T.R.H. by thyroid hormones
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)
EEC and blood pressure effects of T.R.H. in rabbits
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( 1975 )
Release of immunoreactive luteinizing hormone-releasing hormone and
T.R.H. from hypothalamic synaptosomas.
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( 1981 )
Centrally-mediated hyperalgesia ihimice produced by the antimuscarinic
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( 1976 )
The action of psychotropic drugs on dopa induced behavioural responses
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( 1980 )
Evidence for the presence of the putative T.R.H. metabolite, deamido
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( 1980 )
The effects of the T.R.H. and Histidyl-Proline Diketopiperazine on
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180
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( 1981 )
Dissociation of tolerance títthe analgesic and hypothermie Effects of
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T.R.H. in chronic
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Regulation of cyclic G.M.P. in cerebellum by a striatal dopaminergic
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Comparison of the analeptic activity of T.R.H., LH RH, ACTH 4-10 and
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Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin
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Modification of pentobarbital induced sedation by natural and synthetic
peptides
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( 1980 )
Synthesis and analgesic activity of some analogs and derivatives of
L-Histidyl-L-Prolinamide
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)
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Induction of Wet-Dog Shakes by intracerebral "Acid" T.R.H. in rats.
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Prolactin and thyrotropin release in man by synthetic T.R.H.
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Antagonism of ethanol narcosis by T.R.H.
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Interactions of T.R.H. with centrally acting drugs.
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M.A. y PLOTNIKOFF, N.P. ( 1975 )
Effects of T.R.H. on the actions of pentobarbital and other centrally
acting drugs
J. Pharmacol. Exp. Ther., 193 : 11-22
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T.R.H. degradation rates vary widely between different animal species
Biochem. Pharmacology, 30 : 619 - 622
BROWN, M. y VALE, W. ( 1975 a )
Growth hormone release in the rat: effects of somatostatin and T.R.F.
Endrocrinology
: 97 : 1151 - 1156
BROWN, M. y VALE, W. ( 1975 b )
Central nervous system effects of hypothalamic peptides
Endocrinology, 96 : 1333 - 1335
BROWN, M. RIVIER, J. y VALE, W. ( 1977 a )
Bombesin: Potent effects on Thermorégulation in the rat,
Science, 196 : 998 - 1000
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Actions of Bombesin, T.R.H., PGE2 and Naloxone on thermorégulation
in the rat.
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is:
BROWNSTEIN, M.S.., PALKQVITS, M. SAAVEDRA, J.M., BASSIRI, R.M. y
UTIGER, R.D. ( 1974 )
T.R.H. in specific nuclei of rat brain
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Effects of hypothalamic deafferentation on T.R.H. levels in rat brain.
Proc. Nati. Acad. Sei. U.S.A.
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( 1977 )
T.R.H. - T.S.H.
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Structure meléculaire de le facteur hypothalamique hypophysiotrope
T.R.F. d'origine bovine: mise en évidence par spectromètre de masse
de la séquence : PGN-HIS-PRD-NH2
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)
Effect of T.R.H. on Norepinephrine uptake in rat cerebral cortical
homogenates
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CAMPBELL, M. ( 1975 )
Clinical Trials of T.R.H.
Psychopharmac Serv Cent Bull
11, 19-20
CARINO, M.A., SMITH, J.R., WEICK, B.B. y HORITA, A. ( 1976
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The isolation of a new hypotensive peptide, neurotensin, from bovine
hypothalamus.
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Radioimnunoassay for neurotensin, a hypothalamic peptide
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Characterization of radioimmunoassayable neurotensin in the rat,
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Hypothalamic releasing factors and Parkinson's disease
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CHIMARA, K., KATO, y MAEDA, K., ABE, H., FURUMOTO, M. y IMURA, H.
( 1977 )
Effects of T.R.H. on sleep and sleep-related growth hormone release
in normal subjects
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( 1978 )
Endogenous T.R.H. in the anterior pituitary: sites of activity as
identified by immunocytochemical staining.
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185
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Synthetic T.R.H. administered orally to chronic schizophrenic
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( 1975 )
Inhibition of pentobarbital-induced release of growth hormone by
T.R.H.
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Th y TISSOT, R. ( 1974 )
Enhancement of cerebral noradrenaline turnover by T.R.H.: Evidence
by fluorescence histochemistry
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Investigations into the mechanism of reduction of ethanol sleep by T.R.H.
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Antagonism of the analeptic activity of T.R.H. by agents wich enhance
gaba transmission
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186
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A peptide-like substance from pituitary that acts like morphine.
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Mif, T.R.H. and simian social and motor behavior
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Enhancement of noradrenaline responses by T.R.H.
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El T.R.H. en Psicofarmacología
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CUENCA, E., SERRANO, M.I., GIBERT-RAHOLA, J. CARRASCO, M.S. y
ESTEBAN,S.M. ( 197B )
Estudio de la actividad analgésica de la T.R.H. y del M.I.F.
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71 - 76
DAVIS, K.L., HOLLISTER, L.E. y BERGER, P.A. ( 1.975
T.R.H. in schizophrenia
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Effect of T.R.H. and triiodothyronine on prolactine release
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Further attempts to characterize the action of C.A.M.P. and T.R.H.
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The effect of various neurohumoral modulators on the activity of morphine
and the narcotic antagonists in the tail flick and phenilquinone tests.
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DODSON, R.A. y JOHNSON, W.E. (1.979)
Effects of ethanol, arecoline, atropine and nicotine, alone and in various
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Development of the pituitary-thyroid axis in male and female rats
Acta Endocrinologica 84, Suppl : 208, 2 - 3
DOLVA, L., HANSSEN, K.F. y FREY, H.M.M. (1978)
Action of T.R.H. on gastrointestinal functioninman : inhibition
of glucose and xylose absorption from the gut.
Scand. J. Gastroenterol 13 : 599 - 604.
188
DOLVA, L.O., HANSSEN, K.F., BERSTAD, A. y FREY, H.M.
(1979)
T.R.H. inhibits the pentagastrin stimulated gastric secretion in
man: a dose response study.
Clin-Endocrinol 10, 281 - 286
DRAYSON, A.M. (1.974)
T.R.H. in cyclical psychoses
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Synthetic analgesics II Dithienylbutenyl and Dithienylbutylamines.
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Concentrations of T.R.H. and deamido-T.R.H. and T.R.H.-deamidase
activity in brain.
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ENGLER, D., SCANLON, M.F. y JACKSON, I.M.D. (1981)
T.R.H. in the systemic circulation of the neonatal rats is derived
from the pancreas and the extraneuronal tissues
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BAUER, K. y KORDON, C. ( 1979 )
Inhibition of in vitro prolactin secretion by histidyl-prolinediketopiperazine, a degradation product of T.R.H.
European J. Pharmacol,
58 ,
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ESCARTIN, P., ANGLADA, J., CASALS, T., FERRER, G. y PALOP, D. (1977)
Toxicidad crónica de la T.R.H.
: aspectos bioquímicos
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de Farmacólogos (Madrid).
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ESCARTIN, P., ANGLADA, J. y PALOP, D. (1979
a)
Efecto de la T.R.H. administrada por via I.C.V. frente a un
agente nociceptivo físico y otro químico.
Comunicación presentada en la IV Reunión de la A.E.F. y 1§ Reunion
Hispano - Portuguesa de Farmacología (Santiago de Compostela).
ESCARTIN, P., PALOP, D., RODRIGUEZ, L., y VALDECASAS, F.G, (1979 b)
Comparación de dos métodos analgesimétricos. Influencia de la modificación del comportamiento al valorar analgésicos.
Comunicación presentada en la IV Reunión de la A.E.F. y 1§ Reunión
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Opiate antagonists : A role in the treatment of hypovolemic shock.
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Naloxone treatment of endotoxin shock : Stereospecificity of physiologic
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Opiate antagonist improves neurologic recovery after spinal injury
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FADEN, A.I., JACOBS, T.P. y HOLADAY, J.W. ( 1981 b)
T.R.H. improves neurologic recovery after spinal trauma in cats
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T.R.H.: Differential antidepressant and endocrinological effects.
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GASCOIGNE, A.D., HIRST, B.H., REED, J.S. y SHAW, D.B. ( 1980 )
Effects of T.R.H. and methionine-enkefalin on gastric acid and
pepsin secretion in the cat.
Br. J. Pharmac 69, 527 - 534
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T.R.H. is not sole physyologic mediator of prolactin release
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Pituitary thyrotropin response to T.R.H. in affective illness.
Relationship to spinal fluid amine metabolites.
Am. J. Psychiatry, 134 : 1028 - 1031
GOUJET
M.A., SIMON, P., CHERMAT, A. y BOISSIER, U.R. (1.975)
Profil de la T.R.H. en Psychopharmacologie expérimentale
Psychopharmacologia: 45 : 87
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A comparison! of heat and pressure analgesiometric methods in rats.
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T.R.H. potentiates behavioral changes following increased brain
5-hydroxytryptamine accumulattion in rats.
Nature 251
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GREEN, A.R., HEAL, D.J., GRAHAME-SMITH, D.G. y KELLY, P.H. (1976)
The contrasting action of T.R.H. and cycloheximide in altering the effects
of centrally acting drugs: evidence for the non-involvement of dopamine
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Antagonism of the frequency of phenylbenzoquinone induced writhing
in the mouse by weak analgesics and non analgesics.
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