Automatic method to combine three model layers of the cell.

Automatic method to combine three model layers of the cell.
 !
"#$%& &'()
#* )
+, )
-./
!#+$#0"+-&&  )
Motivation
1 2 233%3%4 11 21 21-
  50+67,80+67,83,+441 %% 12    2 
2 9%22+
Models
●1 2
11 2
●2 -
3,2
●$2-
➔#23  2%
➔
6%221 2
Results
●  ● $32%32
Perspectives
●2-3:512 3% 3;%21-
●2 3%-2 :53,&  1-; -
●+232 3-2% < 3=1%%
References
A. M. Abolhassani, J. Da Veiga Moreira, E. Bigan, S. Peres, L. Pauleve, M. Levy Nogueira, J.-M. Steyaert, L. Schwartz, The redox status of
cancer cells supports mechanisms behind the Warburg effect
B. J. Robitaille, J. Chen, M. Jolicoeur, 7>!8A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-
Batch Cultures on Different Culture Media. ?0>7@85>AB!5>CDE3>AB!
C. Y. Bouret, M. Argentina, L. Counillon (2014) Capturing Intracellular pH Dynamics by Coupling Its Molecular Mechanisms within a Fully
Tractable Mathematical Model. ?0@785B!@5>CDE3>>B!@
Contact(52F%
➔
➔+E 2 
23 2
21 7+4+6,8
➔2-
➔6
➔%
(
#3:521222
32
?3:5%%.  - 2(
dV
dt =Vgrowth∗V
dA
dt =Ks Nme
∗A∗[PALM ]
#23  6