3 -D 18 MHz SONOGRAPHY OF EXTRACAPSULAR EXTENSION OF PROSTATE CANCERS

3 -D 18 MHz SONOGRAPHY OF
EXTRACAPSULAR EXTENSION OF
PROSTATE CANCERS
ROBERT L. BARD, M.D.
DIRECTOR
BIOFOUNDATION FOR ANGIOGENESIS RESEARCH & DEVELOPMENT
121 East 60th St. Ste. 6A New York, NY 10022
www.cancerscan.com

OBJECTIVES
DIAGNOSE AND STAGE
EXTRACAPSULAR EXTENSION OF
PROSTATE TUMORS
IMPROVE SURVIVAL SINCE LATE
DETECTION = POOR PROGNOSIS
EVALUATE TREATMENT RESPONSE

DOPPLER FLOW PATTERNS
•BENIGN FLOW IS MICROVASCULAR
•MALIGNANT FLOWS ARE NOT
MICROVASCULAR SUGGESTING
VISUALIZATION OF FEEDING VESSELS IN
HIGH GRADE CANCER
•VESSELS PENETRATING CAPSULE
SUGGEST EXTRACAPSULAR DISEASE
LOUVAR E ARRS 1996
PATHOPHYSIOLOGY OF INCREASED
PROSTATIC COLOR DOPPLER FLOWS

TREATMENT RESPONSE
•VASCULARIZATION OF TUMORS DETERMINES
BIOLOGIC BEHAVIOR
•REDUCTION OF VESSELS IN TUMOR
CORRELATES WITH THE RESPONSE
OF THERAPEUTIC EFFECTIVENESS
CORNUD F PROSTATE IMAGING JFR 2005
BARD R CANCER NEOVASCULARITY JFR 2010

MATERIALS AND METHODS
•PROSPECTIVE STUDY
•11 MONTHS 3D / DOPPLER / MRI
•139 PATIENTS GLEASON > 6
•3D 18 MHz IMAGING 1.5 T MRI
•SCANS WITHIN 1 WEEK TIMEFRAME
•42 EXTRACAPSULAR TUMORS
•22 ANTERIOR TUMORS IDENTIFIED