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Progesterone and endometrium
Claire Bourgain

JLO,Liège, 24 septembre 20092
Setting the problem
Million Woman Study
Standardized incidence for endometrial cancer/1000 woman 5y FU
Lancet, 2005
Low incidence of endometrial cancer

JLO,Liège, 24 septembre 20093
Hormone replacement therapy
Relieves menopauzal symptoms
Increased risk for hormone-dependent malignancies
Difference between ERT and HRT
Difference in breast and endometrium
Unopposed estrogen will increase the risk for
endometrial hyperplasia and cancer
Need for progesterone-protection of the
endometrium

JLO,Liège, 24 septembre 20094
Hyperplasia-carcinoma progression

JLO,Liège, 24 septembre 20095
Dualistic pathogenic model of carcinoma
Type I carcinoma
Hyperplasia precursor
HRT concerns Type I Ca
Low-grade
Indolent
Low incidence