Open access

STRATEGY FOR
ASSESSING IMPACTS
OF THYROID
DISRUPTING
CHEMICALS
IN TELEOSTEANS
Joseph G. Schnitzler,
Klaren P. H. M., Celis N., Blust R.,
Covaci A., Dirtu A. C.,
Silvestre F., Das K.

Endocrine disruptors
synthetic chemicals
mimic or block hormones
disrupt hormone function
Marine organisms presents high
concentrations of EDCs

Thyroid = targed for EDCs?
Thyroxine Triiodothyronine
Cl
Cl
Cl
Cl
Cl
DDT
(Cl)n
(Cl)n
PCB
Similar chemical
structures as thyroid
hormones
May generate an
endocrine disruption

Thyroid toxicants
Generally defined as compounds that alter
thyroid hormones levels
116 environmental compounds are suspected
Studies often incorporate an incomplete
picture of dynamic relationships within the
HPT axis
Important to capture indicative endpoints
Current study present some methods

Experimental design
Day 0: 15g et 11cm Day 120: 30g et 15cm
5 tanks containing each 15 sea bass
[7 tracer PCBs] A1254 & A1260