Table 2 Comparison of the different methodologies for dose estimation employed by the three centres
Wiseman et al. [10,11] IEO
a
INT (present paper)
Gammacamera calibration Patient relative Patient relative Absolute-MIRD16
ROI drawing method NA Different ant/post ROIs Identical ant/post ROIs
Attenuation correction One value for all organs Blank/transmission—
one value for each organ
Blank/transmission—
one value for each organ
Scatter correction No Dual window on 171 keV peak Pseudo extrapolation numbers
Background correction NA Integral background subtraction Partial background subtraction
Kidney evaluated NA Left and right Left and right
Heart residence time NA 100% heart content 90% heart content; 10% heart wall
AUC calculation Multi-exponential fit Multi-exponential fit Sum of trapezoid+monoexponential
extrapolation
Individual organ masses Measured on CT except for kidneys Measured on CT Measured on CT
S values source MIRDOSE 3.1 OLINDA/EXM OLINDA/EXM
a
Details on the IEO methodology were kindly provided by Dr. Marta Cremonesi (personal communication)