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Mémoire Immunitaire
Behazine Combadi
è
re,
Behazine Combadi
è
re,
Directeur de recherche
INSERM
GEIG, Nice 27 novembre 2009

Réponse primaire Réponse secondaire
Bcell immune responses and MemoryBcell immune responses and Memory
Memory cells

Magnitude of responses
Intermediate
Memory (3-10 years) Long-term
Memory >10 years
Primary
response
Secondary
response
T cell immune responses and MemoryT cell immune responses and Memory
Prolif. Contr
action Immune memoryProlif. Contraction
Tissues
migration
Magnitude of responses
Time
T cell response
antigen
THRESHOLD of DETECTION
Naive T cells
Effector
memory pool
Central
memory pool
10-6 10-1/-2 10-4 10-5
10-4

Differentiation of effector /memory T lymphocytes
CD4+
3H-thymidine assays (5days)
Proliferative cells
Elispot / intracellular cytokine staining (ICS) (few hours)
Cytokine-producing cells
CD8+

Cellules B chez l’enfant et les personnes âgées:
Limites de la réponse immunitaire
Cellules B chez l’enfant et les personnes âgées:
Limites de la réponse immunitaire