Chemistry versus Bio, Georges Massiot, CNRS, FR
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Chemistry vs Bio Concarneau, le 30 septembre 2011 Georges Massiot, Unité mixte CNRS Pierre-Fabre Epigenetic Targeting of Cancer USR CNRS – Pierre Fabre n° 3388 I Marine resources • Large, diverse, unlimited • Unexplored • May find uses in: • Health • Technologies (Bio) • Energy • Supply of raw materials Georges Massiot l 30 septembre 2011 Concarneau Epigenetic Targeting of Cancer USR CNRS – Pierre Fabre n° 3388 I Marine resources and Health • Health ? • There is still need for new treatments • To replace inefficient treatments • To treat neglected diseases • Solutions ? • Chemistry (NCE) • Biology (NBE) • Biotechnologies Georges Massiot l 30 septembre 2011 Concarneau Epigenetic Targeting of Cancer USR CNRS – Pierre Fabre n° 3388 I Drugs from Marine origin • Vidarabine, Cytarabine • ET-743 Yondelis (ectinascidin) • Prialt • Eribulin Georges Massiot l 30 septembre 2011 Concarneau Epigenetic Targeting of Cancer USR CNRS – Pierre Fabre n° 3388 I Successes and failures • Saxitoxin • Discodermolide • Girolline Georges Massiot l 30 septembre 2011 Concarneau Epigenetic Targeting of Cancer USR CNRS – Pierre Fabre n° 3388 I The eribulin story NP discovered in 1986 Targets tubulin Synthesis of NP in 1992 Synthesis of analogs … Approved in 2010 Georges Massiot l 12 mai 2011 - Marseille Epigenetic Targeting of Cancer USR CNRS – Pierre Fabre n° 3388 I As a temporary conclusion … • There are interesting molecules in the marine environment • If one looks for development as a drug, do not forget the rules : • good pharmaceutical properties • solid IP protection • availability • Source is the key issue • Nature or chemistry ? • Better consider oceans as a source of inspiration than a ressource Georges Massiot l 12 mai 2011 - Marseille Epigenetic Targeting of Cancer USR CNRS – Pierre Fabre n° 3388
