tumor budding in colorectal cancer
TUMOR BUDDING IN COLORECTAL CANCER
CLINICAL APPROACH
Prof. A. Lugli, MD
Division of Clinical Pathology
University of Bern
Symposium de Gastroentérologie –Aurigen
Lausanne, April 10th 2014
BIOLOGY OF TUMOR BUDDING
PROGNOSTIC AND PREDICTIVE IMPACT
SURGICAL PATHOLOGY OF TUMOR BUDDING
CONCLUSION
CONTENT
THE IMPORTANCE OF
TUMOR MICROENVIRONMENT
Hanahan and Weinberg, Cell 2011
THE TUMOR MICROENVIRONMENT
Hanahan and Weinberg. Cell 2011
TUMOR BUDS
Definition
Single tumor cells or cluster up to
5 tumor cells at the invasive
margin
EMT like cells
Transformation to a motile and
invasive phenotype
Low proliferation
Potentially malignant stem cells
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