GOFFIN Vincent - L`Institut de Formation Doctorale

GOFFIN Vincent :: UMR_S1151 UMR8253 :: Physiopathologie des hormones PRL/GH :
Approches transversales
Unité de recherche : INSERM UMR_S1151 CNRS UMR8253 Institut Necker-Enfants Malades
(INEM) Université Paris Descartes :
Faculté de Médecine Paris Descartes
Bâtiment Leriche – PORTE 9
2ème étage - Bureau L-213
96 rue Didot, CS 61431
75993 PARIS Cedex 14
Directeur de l'unité de rattachement : : Xavir NASSIF
Responsable de l'équipe de recherche : Vincent GOFFIN
GOFFIN Vincent
Courriel : [email protected] Tel: [phone]
Composition de l'équipe de recherche : :
GOFFIN Vincent (DR2-INSERM (CL), HDR)
CAPIOD Thierry (CR1-INSERM, HDR)
BARRY-DELONGCHAMPS Nicolas (MCU-PH)
CHAKHTOURA Zeina (PH)
GUIDOTTI Jacques-Emmanuel (CR1-INSERM)
KELLY Paul (PUPH Emérite)
TOURAINE Philippe (PUPH, HDR)
5 publications récentes de l'équipe de recherche : :
Goffin V, Hoang DT, Bogorad RL, Nevalainen MT 2011 Prolactin regulation of the prostate gland: a female player in a
male game. Nat Rev Urol 8:597-607
Broutin I, Jomain JB, Tallet E, Van Agthoven J, Raynal B, Hoos S, Kragelund BB, Kelly PA, Ducruix A, England P,
Goffin V 2010 Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology
of hormone binding site 2. J Biol Chem 285:8422-8433
Rouet V, Bogorad RL, Kayser C, Kessal K, Genestie C, Bardier A, Grattan DR, Kelder B, Kopchick JJ, Kelly PA, Goffin
V 2010 Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors. Proc Natl Acad Sci U S A
107:15199-15204
Bogorad RL, Courtillot C, Mestayer C, Bernichtein S, Harutyunyan L, Jomain JB, Bachelot A, Kuttenn F, Kelly PA,
Goffin V, Touraine P 2008 Identification of a gain-of-function mutation of the prolactin receptor in women with benign
breast tumors. Proc Natl Acad Sci U S A 105:14533-14538

Jomain JB, Tallet E, Broutin I, Hoos S, Van Agthoven J, Ducruix A, Kelly PA, Kragelund BB, England P, Goffin V 2007
Structural and thermodynamical bases for the design of pure prolactin receptor antagonists. X-ray structure of
Del1-9-G129R-hPRL. J Biol Chem 282:33118-33131