Nutrition et prévention : Données issues des cohortes et des études

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CESP Center for Research in Epidemiology and Population Health
Nutrition et prévention :
Données issues des
cohortes et des études
d’intervention
Dr Marie-Christine Boutron-Ruault
Inserm U1018 équipe 9, Université Paris 11 et Institut Gustave Roussy
et Hôpital Antoine Béclère, Clamart
iCEPS Conference, Montpellier 19-21 mars 2015
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Mécanismes activateurs et protecteurs
D’après : Alimentation, nutrition et prévention des cancers, une perspective mondiale :
applications au contexte français, Nacre WCRF, 2002.
http://www.inra.fr/reseau-nacre/infosci/NACReWCRFAccueil.htm

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Meta-analysis of available studies
2007
2nd WCRF-AICR
expert report
(World Cancer Research
Fund – American Institute
for Cancer Research)
+Continuous Update Program
Alcohol and cancer: WCRF recommendations
• Evidence on cancer justifies not to drink
alcoholic drinks; for people that consume
alcohol, limit to one drink per day in women and
two drinks/d in men
• Evidence is convincing for
– Mouth, pharynx and larynx
– Esophagus
– Breast
– Colorectal (men)

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Alcohol and breast cancer: Cohort Studies
Plant Foods

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RR per 100 g/day increment for F&V
Breast
Lung
Bladder
Colon, rectum
Stomach
Œsophagus
Larynx
Mouth and pharynx
Case-control studies
Cohort studies
Breast
Lung
Bladder
Colon, rectum
Stomach
RR (95% Confidence Interval)
0.99 (0.96-1.01)
0.92 (0.84-1.01)
0.92 (0.75-1.14)
0.96 (0.90-1.05)
0.88 (0.79-0.98)
0.86 (0.78-0.94)
0.86 (0.78-0.94)
0.90 (0.78-1.03)
0.87 (0.80-0.95)
0.77 (0.70-0.84)
0.91 (0.82-1.01)
0.92 (0.83-1.02)
0.84 (0.67-1.07)
0.2 0.4 0.6 0.8 1 1.2 RR
Riboli E & Norat T. Am J Clin Nutr. 2003 Sep;78(3 Suppl):559S-569S.
Fruit & vegetables and cancer risk

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Fruit and lung cancer risk (WCRF)
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Cruciferous vegetables consumption and the risk of female
lung cancer: a prospective study and a meta-analysis
Ann Oncol 2013, Wu QJ et al