chugh2013

Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study
Sumeet S. Chugh, Rasmus Havmoeller, Kumar Narayanan, David Singh, Michiel Rienstra,
Emelia J. Benjamin, Richard F. Gillum, Young-Hoon Kim, John H. McAnulty, Jr, Zhi-Jie
Zheng, Mohammad H. Forouzanfar, Mohsen Naghavi, George A. Mensah, Majid Ezzati and
Christopher J.L. Murray
Circulation. 2014;129:837-847; originally published online December 17, 2013;
doi: 10.1161/CIRCULATIONAHA.113.005119
Circulation is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231
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Arrhythmia/Electrophysiology
Worldwide Epidemiology of Atrial Fibrillation
A Global Burden of Disease 2010 Study
Sumeet S. Chugh, MD; Rasmus Havmoeller, MD, PhD; Kumar Narayanan, MD;
David Singh, MD; Michiel Rienstra, MD, PhD; Emelia J. Benjamin, MD, ScM;
Richard F. Gillum, MD; Young-Hoon Kim, MD; John H. McAnulty, Jr, MD;
Zhi-Jie Zheng, MD, PhD; Mohammad H. Forouzanfar, MD; Mohsen Naghavi, MD;
George A. Mensah, MD; Majid Ezzati, PhD; Christopher J.L. Murray, MD
Background—The global burden of atrial fibrillation (AF) is unknown.
Methods and Results—We systematically reviewed population-based studies of AF published from 1980 to 2010 from
the 21 Global Burden of Disease regions to estimate global/regional prevalence, incidence, and morbidity and mortality
related to AF (DisModMR software). Of 377 potential studies identified, 184 met prespecified eligibility criteria. The
estimated number of individuals with AF globally in 2010 was 33.5 million (20.9 million men [95% uncertainty interval
(UI), 19.5–22.2 million] and 12.6 million women [95% UI, 12.0–13.7 million]). Burden associated with AF, measured
as disability-adjusted life-years, increased by 18.8% (95% UI, 15.8–19.3) in men and 18.9% (95% UI, 15.8–23.5) in
women from 1990 to 2010. In 1990, the estimated age-adjusted prevalence rates of AF (per 100 000 population) were
569.5 in men (95% UI, 532.8–612.7) and 359.9 in women (95% UI, 334.7–392.6); the estimated age-adjusted incidence
rates were 60.7 per 100 000 person-years in men (95% UI, 49.2–78.5) and 43.8 in women (95% UI, 35.9–55.0). In 2010,
the prevalence rates increased to 596.2 (95% UI, 558.4–636.7) in men and 373.1 (95% UI, 347.9–402.2) in women;
the incidence rates increased to 77.5 (95% UI, 65.2–95.4) in men and 59.5 (95% UI, 49.9–74.9) in women. Mortality
associated with AF was higher in women and increased by 2-fold (95% UI, 2.0–2.2) and 1.9-fold (95% UI, 1.8–2.0)
in men and women, respectively, from 1990 to 2010. There was evidence of significant regional heterogeneity in AF
estimations and availability of population-based data.
Conclusions—These findings provide evidence of progressive increases in overall burden, incidence, prevalence, and
AF-associated mortality between 1990 and 2010, with significant public health implications. Systematic, regional
surveillance of AF is required to better direct prevention and treatment strategies. (Circulation. 2014;129:837-847.)
Key Words: atrial fibrillation ◼ epidemiology ◼ incidence ◼ prevalence ◼ risk factors, prevention
A
trial fibrillation (AF) is the most common arrhythmia of
clinical significance.1 In adjusted models, AF is associated
with increased morbidity, especially stroke and heart failure, and
increased mortality.2–5 AF constitutes a significant public health
problem, and estimates suggest that this condition accounts
for 1% of the National Health Service budget in the United
Kingdom6 and $16 to 26 billion of annual US expenses.7,8
Editorial see p 829
Clinical Perspective on p 847
Several regional studies suggest a rising prevalence and
incidence of AF.9–13 These secular trends may be explained
in part by the demographic transition to an inverted age pyramid because frequency of AF increases with advancing age.
Others have demonstrated an increase in AF incidence after
age adjustment, which is probably a reflection of comorbidities
and cardiovascular risk factors, in addition to other factors such
as lifestyle changes.14,15 In the United States, it is estimated that
the number of adults with AF will more than double by the year
2050;16 even higher increases have been predicted.14
Received July 22, 2013; accepted November 12, 2013.
From the Cedars-Sinai Heart Institute, Los Angeles, CA (S.S.C., R.H., K.N., D.S.); Karolinska Institute, Stockholm, Sweden (R.H.); University of
Groningen, University Medical Center Groningen, Groningen, the Netherlands (M.R.); Framingham Heart Study and Boston University School of Medicine
and Public Health, Boston, MA (E.J.B.); Department of Medicine, Howard University College of Medicine, Washington, DC (R.F.G.); Korea University
College of Medicine, Seoul, Republic of Korea (Y.-H.K.); Legacy Good Samaritan Medical Center, Portland, OR (J.H.M.); National Heart, Lung, and
Blood Institute, Bethesda, MD (Z.-J.Z., G.A.M.); Institute for Health Metrics and Evaluation, University of Washington, Seattle (M.H.F., M.N., C.J.L.M.);
and Harvard School of Public Health, Boston, MA (M.E.).
Guest Editor for this article was Mercedes Carnethon, PhD.
The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIRCULATIONAHA.
113.005119/-/DC1.
Correspondence to Sumeet S. Chugh, MD, The Heart Institute, AHSP Ste A3300, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles,
CA 90048. E-mail [email protected]
© 2013 American Heart Association, Inc.
Circulation is available at http://circ.ahajournals.org
DOI: 10.1161/CIRCULATIONAHA.113.005119
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State University--Corvallis on June 17, 2014
837
838 Circulation February 25, 2014
In view of the emergence of AF as a growing epidemic,15,17
an assessment of the global burden of AF is warranted. We
therefore conducted a comparative assessment of the burden
of AF across defined time periods based on available epidemiological data from the 21 Global Burden of Disease (GBD)
regions.
Methods
The GBD Study
Our analysis was performed within the framework of the latest Global
Burden of Disease, Injuries, and Risk Factors Study (GBD 2010
Study).18 The GBD 2010 Study is a collaborative effort led by a consortium that includes Harvard University, the Institute for Health Metrics
and Evaluation at the University of Washington, Johns Hopkins
University, the University of Queensland, the University of Tokyo,
Imperial College London, and the World Health Organization. It follows
on the original GBD 1990 Study commissioned by the World Bank in
1991 and aims to systematically assess global data on all diseases and
injuries. GBD 2010 provides a common instrument for assessing mortality and morbidity. The goal was to provide comparable estimates at
different time periods with analysis of secular trends. Detailed information about the data, techniques, and methods for estimation of different
disease parameters has been published elsewhere.19–21
Search Strategy and Data Sources
As a subcommittee of the GBD 2010 Committee on Cardiovascular
Disease and following the GBD 2010 protocol, the GBD Arrhythmias
Panel performed a systematic review of the available literature
(Appendix I in the online-only Data Supplement) to identify epidemiological studies of AF (1980–2010) that were population based. For
the initial identification of published studies, we used the following
search terms: atrial fibrillation, atrial flutter, epidemiology, incidence,
prevalence, mortality, and case fatality rate. MEDLINE, EMBASE,
and LILACS were queried for studies published between 1980 and
2010 (for LILACS, the time period was 1982–2010). There were no
restrictions based on language of publication. Details of the search
are outlined in Appendix II in the online-only Data Supplement.
The initial search (phase 1) generated abstracts that were reviewed
(phase 2) on the basis of prespecified inclusion and exclusion criteria (Appendix III in the online-only Data Supplement). Whereas all
studies on AF epidemiology in the general population were included,
studies conducted on selected clinical subgroups such as inpatients
or those with heart failure were excluded to arrive at accurate estimates of AF burden at a population-wide level. The selected abstracts
underwent full text reviews (phase 3) to confirm eligibility, generating
a final list of publications selected for abstraction. Each publication
was assigned to 1 of 21 epidemiological regions as designated in
GBD 2005. To minimize potential bias resulting from inconsistent
case definitions of AF, all published studies of paroxysmal, persistent,
or permanent/chronic AF and atrial flutter were included.
Statistical Methods
Incidence rate was defined as the annual number of new cases with
AF divided by the population at midyear. Prevalence rate was defined
as the overall number of cases with the total population as denominator. Prevalence and incidence rates were age adjusted. Rates were
presented per 100 000 persons or person-years with 95% uncertainty
intervals (UIs). The denominators were derived from the United
Nations population database (http://www.un.org/esa/population/),
and classifications of countries, regions, and groups (eg, developed
and developing countries) followed the definitions of the World Bank
(http://data.worldbank.org/about/country-classifications) and GBD
core team decisions.22
Modeling of AF as a Cause of Death
Mortality associated with AF was estimated by use of an integrated
method, with information on several country-level covariates used
to inform the analysis.19 All combinations of the covariates with a
significant coefficient (P<0.05) and expected direction of the effect
were used to estimate the number of deaths. The performance of each
model in terms of external validity was evaluated and constituted the
final ensemble model estimate. External validity criteria were used
to rank all models and to produce ensemble results.23 The covariates
and external validity of the ensemble model are reported in Appendix
IV (Tables I and II in the online-only Data Supplement). In the next
step, each individual cause of death was adjusted to obtain overall
cardiovascular mortality (CoDCorrect process).19 The GBD method
provides the mortality rate attributable to AF as opposed to total case
fatality rate in AF patients.
Modeling of Morbidity Associated With AF
We used incidence, prevalence, excess mortality, and AF mortality
rate (estimated by the CODEm process) in a bayesian m
­ eta-regression
tool (DisMod-MR: Figure 1).21,24 DisMod-MR estimates a generalized negative binomial model for all the epidemiological data with
fixed and random effects. Data modeled with fixed effects include
age, covariates that predict country variation in the quantity of interest, variation across studies resulting from attributes of the study
protocol, and random effects of super-region, region, and country.
DisMod-MR can be used to estimate age-, sex-, and country-specific
prevalence from heterogeneous and often sparse data sets. We used
Figure 1. Conceptual disease model. Flow chart illustrating the conceptual disease model used (DisMod-MR software). The model
includes the number of people without the disease (atrial fibrillation in this case), the number of people with the disease, the number
of deaths associated with the disease, and the number of deaths resulting from all other causes. The transitions between these states
are represented by incidence (i), remission (m), case fatality (f), and all other mortality (m). In the case of atrial fibrillation, remission was
assumed to be zero. (Modified from Barendregt et al.24 Copyright © 2003 Barendregt et al; licensee BioMed Central Ltd.)
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Chugh et al Global Burden of Atrial Fibrillation 839
DisMod to estimate the total number of patients living with AF. The
history of at least 1 confirmed AF episode is the common definition
of AF used in prevalence studies. We used this definition in the modeling and estimation of different epidemiological parameters such as
prevalence, incidence, and case fatality (excess mortality rate).21
As for all conditions assessed in the GBD project, burden associated with AF was measured as disability-adjusted life-years (DALYs).
The DALY metric was introduced in the original GBD 1990 study as a
means of assessing the disability of chronic disorders.22 DALYs combine information on premature death (years of life lost) and disability
caused by the condition (years lived with disability). One DALY corresponds to 1 lost year of health and is calculated as years of life lost
plus years lived with disability. As previously described in detail,25,26
years lived with disability are calculated by multiplying the estimated
number of incident cases by the average duration of the disease and a
disability weight factor (range, 0–1, where 0 is total health and 1 is total
disability). Disability weights for sequelae of multiple disease conditions were estimated by 4 population-based surveys in Bangladesh,
Indonesia, Peru, and Tanzania; a telephone survey in the United States;
and an open-access Web-based survey.27 AF sequelae were defined as
“daily medication and at least minimal interference with daily activities” and accordingly assigned a disability weight of 0.031.
Role of the Funding Source
The funding sources had no influence over the study, the interpretation of the results, writing of the manuscript, or decision to submit for
publication. The corresponding author had full access to all the data
in the study and had final responsibility for the decision to submit for
publication.
Results
Data Availability
The initial search generated 4574 abstracts (Appendix I in the
online-only Data Supplement). Of these, 377 published studies (8.2%) were identified as meeting initial criteria. After a
full text review, 193 studies were excluded (ie, did not meet
the prespecified quality measures), and the remaining184
studies moved to the abstraction stage. The majority of studies
were from Western Europe and North America (35.9% and
35.6% of included data sources, respectively).
Prevalence of AF
Table 1 shows the estimated age-adjusted AF prevalence
rates stratified by sex (Figure 2; complete data for all GBD
regions are given in Table Ia and Ib in the online-only Data
Supplement). In 1990, the estimated global prevalence rates
(per 100 000 population) were 569.5 (95% UI, 532.8–612.7)
in men and 359.9 (95% UI, 334.7–392.6) in women. In 2010,
prevalence rates were 596.2 (95% UI, 558.4–636.7) in men
and 373.1 (95% UI, 347.9–402.2) in women. The prevalence rates showed a modest increase between 1990 and
2010 (Figure 3) across both sexes. Developed countries had
higher prevalence rates compared with developing countries;
however, this difference was more pronounced in men than
in women. For all time points, the prevalence was higher in
men compared with women. There was significant variation in prevalence between GBD regions. The lowest prevalence rates (2010) were estimated in the Asia-Pacific region
for both men and women (340.2 and 196.0, respectively).
The highest rates were estimated in North America (925.7
for men and 520.8 for women). The prevalence and incidence for Sub- Saharan Africa were lower compared with
a developed region such as North America. Overall, for the
Sub-Saharan Africa super-region, in 2010, the prevalence of
AF (age-adjusted, per 100 000 population) was 659.8 (95%
UI, 511.0–850.4) for men and 438.1 (95% UI, 340.2–561.0)
for women. The median change in prevalence was higher in
developed countries, with the largest increase noted in North
America (40.1%) and the least change in Sub-Saharan Africa,
East (3.4%; Table II in the online-only Data Supplement).
Prevalence rates increased significantly with increasing age
(Figures IA and IB in the online-only Data Supplement),
with rates in the ­≥35-year-old population observed to be
more than double the overall prevalence. With the DisMod
MR-estimated prevalence rates applied to the world population of 2010, the estimated number of individuals with AF
globally is 20.9 million men (95% UI, 19.5–22.2 million)
and 12.6 million women (95% UI, 12.0–13.7 million).
Incidence of AF
Table 2 shows the estimated age-adjusted incidence rates
of AF stratified by sex (complete data for all GBD regions
are given in Table IIIa and IIIb in the online-only Data
Supplement). In 1990, the overall incidence rates of the world
population were 60.7 (95% UI, 49.2–78.5) per 100 000 person-years in men and 43.8 (95% UI, 35.9–55.0) in women.
In 2010, the estimated incidence rates were higher, 77.5
(95% UI, 65.2–95.4) in men and 59.5 (95% UI, 49.9–74.9)
Table 1. Estimated Age-Adjusted Prevalence Rates With 95% Uncertainty Intervals of Atrial Fibrillation (per 100 000 Population)
for Men and Women
1990
1995
2000
2005
2010
Men
Global, all ages
569.5 (532.8–612.7)
578.1 (541.2–620.9)
586.8 (549.8–629.5)
595.1 (557.3–639.0)
596.2 (558.4–636.7)
1307.4 (1222.5–1407.3)
1327.3 (1243.2–1425.7)
1347.6 (1263.4–1445.8)
1366.6 (1281.0–1467.1)
1368.5 (1280.8–1462.7)
Developed countries
608.2 (547·0–693.5)
625.6 (564.0–712.5)
643.1 (580.3–730.2)
660.0 (594.5–740.8)
660.9 (597.1–738.2)
Developing countries
546.6 (503.0–599.6)
551.1 (506.6–604.8)
555.8 (511.0–610.1)
561.3 (517.5–618.4)
565.7 (522.9–617.6)
Global, all ages
359.9 (334.7–392.6)
363.4 (338.5–395.3)
366.7 (342.0–397.8)
369.6 (345.5–399.9)
373.1 (347.9–402.2)
Age ≥35 y
826.5 (768.4–902.3)
834.7 (776.6–909.2)
842.3 (784.7–915.5)
849.0 (792.4–919.6)
856.8 (797.7–923.5)
Developed countries
362.5 (319.3–422.3)
370.1 (326.7–429.5)
377.5 (334.0–436.8)
385.1 (340.1–446.8)
387.7 (343.8–450.0)
Developing countries
358.2 (329.8–393.0)
359.0 (330.8–394.0)
359·8 (331.5–395.0)
360.9 (331.6–396.0)
366.1 (337.4–400.8)
Age ≥35 y
Women
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840 Circulation February 25, 2014
Figure 2. World map showing the age-adjusted prevalence rates (per 100 000 population) of atrial fibrillation in the 21 Global Burden of
Disease regions, 2010.
in women, as shown in Figure 4. There were significantly
higher (≈2-fold) incidence rates in developed regions compared with developing countries. For both time periods, similar to the observations for prevalence, AF incidence rates
were higher in men compared with women. Again, there
was great variation between GBD regions. The lowest incidence rates (2010) were estimated in the Asia-Pacific region
for both men and women (33.8 and 19.8, respectively). The
highest rates were estimated in North America (264.5 for
men and 196.3 for women). As for prevalence, the incidence
rates were also lower in the Sub-Saharan region, reported
as 58.4 (95% UI, 43.7–78.5) and 42.7 (95% UI, 31.1–60.5)
in men and women, respectively. Incidence rates were also
higher in the older age groups (Figure IIA and IIB in the
online-only Data Supplement).
When the estimated incidence rates are applied to the
world population of 2010, the estimated number of new
AF cases per year is 2.7 million (95% UI, 2.3–3.3 million) for men and 2.0 million (95% UI, 1.7–2.6 million)
for women.
Figure 3. Prevalence of atrial fibrillation: 1990 to 2010. Estimated age-adjusted global prevalence of atrial fibrillation (per 100 000
population) for men and women from 1990 to 2010.
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Chugh et al Global Burden of Atrial Fibrillation 841
Table 2. Estimated Age-Adjusted Incidence Rates with 95%
Uncertainty Intervals of Atrial Fibrillation (per 100 000 Personyears) for Men and Women
1990
2010
Men
Global, all ages
60.7 (49.2–78.5)
77.5 (65.2–95.4)
141.0 (114.6–182.6)
181.2 (152.6–222.8)
Developed countries
78.4 (67.5–91.9)
123.4 (107.6–141.5)
Developing countries
50.0 (33.8–76.8)
53.8 (38.7–79.8)
43.8 (35.9–55.0)
59.5 (49.9–74.9)
Age ≥35 y
increases of 18.8% (95% UI, 15.8–19.3) and 18.9% (95% UI,
15.8–23.5) for men and women, respectively (Table 4; complete data for all GBD regions are given in Table Va and Vb
in the online-only Data Supplement; see Figure 8). In keeping
with the higher incidence and prevalence of AF, DALYs were
higher in developed compared with developing countries.
The rate of change in DALYs was also higher in developed
compared with developing countries (Table II in the onlineonly Data Supplement).
Discussion
Women
Global, all ages
Age ≥35 y
102.0 (83.9–127.9)
139.7 (117.1–175.3)
Developed countries
52.8 (45.0–62.9)
90.4 (77.8–104.5)
Developing countries
36.0 (24.5–54.7)
40.0 (27.2–62.6)
Mortality and Disease Burden Associated With AF
The age-adjusted mortality rate (per 100 000 population)
for AF in 1990 was 0.8 (95% UI, 0.5–1.1) for men and 0.9
(95% UI, 0.7–1.2) for women. The age-adjusted mortality rate
increased to 1.6 (95% UI, 1.0–2.4) and 1.7 (95% UI, 1.4–2.2)
in 2010, representing 2-fold (95% UI, 2.0–2.2) and 1.9-fold
(95% UI, 1.8–2.0) increases, for men and women, respectively
(Table 3; full data for all GBD regions are provided in Table
IVa and IVb in the online-only Data Supplement). Mortality
increased steadily through 1995, 2000, and 2005 (Figure 5),
especially in the developed world. Mortality associated with
AF was higher in women overall; this was driven mainly by
comparatively higher mortality in women (compared with
men) in developing countries (Figure 6). In 2010, the estimated numbers of total deaths (men and women) represented
<1% of the global mortality in the vast majority of the 21
GBD regions (Figure 7).
The estimated age-adjusted DALYs (per 100 000 population) resulting from AF were 54.3 (95% UI, 39.2–72.7)
and 38.6 (95% UI, 28.9–50.5) in 1990 for men and women,
respectively. This number increased to 64.5 (95% UI, 46.8–
84.2) and 45.9 (95% UI, 35.7–58.5) in 2010, representing
Figure 4. Incidence of atrial fibrillation: 1990 and 2010. Estimated
age-adjusted global incidence (per 100 000 person-years) for
men and women for 1990 and 2010.
Our systematic review of the current worldwide epidemiological data on AF confirms the emergence of this condition
as a global epidemic with significant and progressive effects
on estimated disability and mortality. Furthermore, there
were specific differences identified on the basis of age and
GBD region that are likely to have significant implications for
global public health.
As expected, higher rates of AF were observed in older age
groups. For example, men 75 to 79 years of age have double
the prevalence rate compared with men 65 to 69 years of age
and >5-fold higher prevalence compared with men 55 to 59
years of age. The 2010 rates are higher than the 1990 rates,
with increases in both prevalence and incidence rates in both
sexes. Other regional studies have reported an increasing prevalence of AF, especially in the developed world. Piccini et al13
reported a greater increase in the prevalence of AF (from 41.1
to 85.8 per 1000 between 1993 and 2007, with an annual rate
of increase of ≈5%) compared with the present study, which
is likely to be related to differences in the population studied, with the former study being restricted to elderly Medicare
beneficiaries in the United States. The annual new cases of AF
globally in 2010 were estimated at close to 5 million, which,
together with the increasing trends observed, highlights the
observation that the burden of AF is growing rapidly.
The exact reasons for these trends are unknown but may be
partly explained by aging trends in the global population. One
hypothesis for the increasing incidence is that AF in the majority of people is a vascular disease caused by hypertension,
atherosclerosis, and other cardiovascular risk factors, which
increase arterial stiffness and cause diastolic dysfunction and
atrial volume overload, resulting in AF. Analysis of global risk
factors in the GBD 2010 study showed that high blood pressure
is the number 1 risk factor globally (increasing from the fourth
position in 1990), accounting for 7% of all global DALYs.
High body mass index ranks sixth in the global list, ascending
from the 10th position in 1990. Deaths attributable to hypertension increased by 28.8% from 1990 to 2010, whereas deaths
attributable to obesity increased by 71.7%.18 Thus, it appears
that the increase in AF burden potentially could be linked to
risk factors such as hypertension and obesity at a global level.
Although these alterations can be observed as part of the aging
process, they are also likely to be involved independently of
aging. Although a renewed focus on risk factors may help,
other contributors to increasing AF incidence such as aging of
the population, better survival from other disease conditions,
and improved diagnosis also need to be acknowledged.
Temporal trends in AF prevalence may also result from lead
time bias (such that AF cases may be diagnosed earlier in their
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842 Circulation February 25, 2014
Table 3. Estimated Age-Adjusted Mortality Rates With 95% Uncertainty Intervals (per 100 000 Population) Associated With Atrial
Fibrillation for Men and Women
1990
1995
2000
2005
2010
Global, all ages
0.8 (0.5–1.1)
0.9 (0.6–1.3)
1.1 (0.7–1.5)
1.3 (0.8–1.8)
1.6 (1.0–2.4)
Age ≥35 y
1.9 (1.3–2.8)
2.2 (1.4–3.1)
2.7 (1.7–3.6)
3.2 (2.0–4.4)
3.8 (2.4–5.8)
Developed countries
1.3 (0.9–1.9)
1.6 (1.1–2.2)
2.0 (1.3–2.7)
2.3 (1.6–3.2)
2.7 (1.9–4.3)
Developing countries
0.4 (0.2–0.8)
0.4 (0.2–0.8)
0.5 (0.3–0.9)
0.6 (0.3–1.1)
0.7 (0.4–1.3)
Global, all ages
0.9 (0.7–1.2)
1.1 (0.9–1.4)
1.4 (1.2–1.8)
1.7 (1.4–2.1)
1.7 (1.4–2.2)
Age ≥35 y
2.2 (1.8–3.0)
2.7 (2.2–3.4)
3.5 (2.8–4.4)
4.0 (3.4–5.0)
4.2 (3.4–5.4)
Developed countries
1.1 (1.0–1.3)
1.4 (1.2–1.6)
1.9 (1.7–2.2)
2.3 (2.0–2.7)
2.4 (2.0–3.0)
Developing countries
0.7 (0.4–1.4)
0.8 (0.4–1.4)
0.9 (0.5–1.5)
0.9 (0.6–1.6)
1.0 (0.6–1.7)
Men
Women
course) and increased survival from coexistent cardiovascular
conditions such as ischemic heart disease and heart failure.
Improved management of these cardiovascular conditions
may have resulted in a larger high-risk group. In addition,
increased awareness of AF symptoms and clinical diagnosis
likely play a role. Of interest, the change in AF prevalence
from 2005 to 2010 was seen to be minimal, especially among
men in the developed countries as opposed to developing
countries. Although the exact reason for the leveling of prevalence rates is difficult to ascertain, one possibility may be an
improved awareness and focus on management of risk factors
in the developed world.
AF is known to have a significant impact on healthcare
costs, with the major cost drivers being hospitalizations,
stroke, and loss of productivity.6,28,29 In the present study, AF
was associated with <1% of all deaths in most World Health
Organization regions. However, AF is known to coexist and
interact with other conditions, contributing to a worse prognosis than for individuals without AF. For example, recent
meta-analyses have shown that patients with heart failure and
myocardial infarction have worse outcomes if they also have
AF.30,31 Moreover, new-onset AF in heart failure patients might
be associated with a particularly poor prognosis.32,33
There were significant variations in the AF burden by
GBD region, with developed countries having a greater burden overall. Recent reports indicate that a higher degree of
European ancestry is associated with an increased predisposition to AF.34 However, part of the global variation in AF
epidemiology may also be attributable to better surveillance
in developed countries. In the 1990 GBD study, no specific
data for AF were reported, but cardiovascular diseases as a
group accounted for 9.7% of the global DALYs, with ischemic heart disease being the fifth ranking disorder in total
number of DALYS (≈47×106), behind lower respiratory
infections, diarrheal diseases, perinatal disorders, and unipolar major depression.35 In 2010, ischemic heart disease
moved up to the number 1 position, with cardiovascular
disease accounting for 11.8% of global DALYs. With the
exception of Sub-Saharan Africa and Oceania, cardiovascular disease ranked among the top 3 causes of DALYs in
most regions.20 In keeping with these trends, DALYs related
to AF increased by ≈18% from 1990 to 2010. Although the
absolute DALYs related to AF (≈52 per 100 000 overall)
are much lower compared with conditions such as chronic
obstructive lung disease (1114 per 100 000), diabetes mellitus (680 per 100 000), and chronic kidney disease (307
Figure 5. Mortality associated with atrial fibrillation:
1990 to 2010. Estimated age-adjusted mortality
(per 100 000 population) associated with atrial
fibrillation from 1990 to 2010. UI indicates
uncertainty interval.
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Chugh et al Global Burden of Atrial Fibrillation 843
Figure 6. Mortality associated with atrial fibrillation (AF) stratified by sex and type of region (developed vs developing). Mortality
associated with AF was higher in men and women in the developed regions. The significantly higher mortality in women in the developing
regions is responsible for the overall higher AF-related mortality among women compared with men.
per 100 000),20 as discussed earlier, AF can interact with
other diseases in multiple ways, potentially contributing to
worse outcomes. The rise of cardiovascular disease burden
in developing countries possibly indicates an ongoing transition toward noncommunicable diseases, previously associated more with developed nations. Especially with current,
rapidly evolving demographic changes in large population
centers of the developing world, the effects of the rising
global AF burden merit careful consideration with respect to
distribution of dwindling healthcare resources. Additionally,
there is an urgent need to design and deploy effective surveillance strategies for AF that will guide future World Health
Organization region-specific prevention.
Limitations
Our study has several limitations. AF is a heterogeneous
condition and in a subset of individuals can be asymptomatic.36,37 Both features underscore the difficulties associated
Figure 7. Proportion of global deaths associated with atrial fibrillation in 2010. The map shows color-coded proportions (in percentages)
of global deaths in 2010 associated with atrial fibrillation.
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844 Circulation February 25, 2014
Table 4. Estimated Age-Adjusted DALYs With 95% Uncertainty Intervals (per 100 000 Population) Associated With Atrial Fibrillation
for Men and Women
1990
1995
2000
2005
2010
Men
Global, all ages
54.3 (39.2–72.7)
56.5 (41.3–75.5)
59.1 (43.5–79.2)
61.7 (45.0–81.4)
64.5 (46.8–84.2)
125.2 (90.5–167.1)
130.4 (95.8–174.0)
136.6 (100.9–182.7)
142.6 (104.1–188.0)
149.3 (108.7–194.5)
Developed countries
63.4 (47.2–83.9)
67.8 (50.7–89.5)
72.8 (54.7–94.9)
77.2 (58.4–100.5)
81.5 (60.8–106.2)
Developing countries
48.2 (33.3–65.6)
49.2 (34.5–67.8)
50.6 (35.6–69.4)
52.2 (36.4–70.9)
54.5 (37.7–73.2)
Global, all ages
38.6 (28.9–50.5)
40.3 (29.9–52.5)
43.1 (32.6–55.3)
45.0 (35.3–57.0)
45.9 (35.7–58.5)
Age ≥35 y
89.3 (67.1–116.6)
93.5 (69.5–121.2)
100.2 (76.1–128.2)
104.6 (82.3–132.1)
106.8 (82.9–135.8)
Developed countries
39.6 (30.0–51.8)
42.6 (32.5–54.7)
47.0 (36.9–59.9)
50.1 (40.0–63.2)
51.0 (39.8–63.7)
Developing countries
37.0 (26.3–49.5)
37.6 (26.6–51.3)
38.9 (27.8–53.2)
39.8 (29.2–52.5)
41.1 (30.5–54.4)
Age ≥35 y
Women
DALY indicates disability-adjusted life-years.
with making accurate estimates of the burden of this disease.
Therefore, our findings could represent an underestimate.
In addition, we note that differences in the extent of patient
surveillance, including access to health care, use of routine
ECGs, and assessment of electrical devices such as pacemakers, may be contributing to secular trends. We also acknowledge the inability of observational data to accurately estimate
the relative importance of various factors contributing to such
trends. Moreover, we cannot rule out the possible impact of
publication bias and did not actively seek out unpublished
manuscripts or data. Estimation of the mortality associated
with AF was based on modeling the causes of death using
input from all available cause of death data. As with any
­cause-of-death analysis, assignment of cause of death may be
prone to some misclassification. Furthermore, any inferences
about future trends should be made with caution because the
rapid development of surveillance and treatment strategies
might change mortality and prevalence rates. Because of the
low availability of data from several regions, our findings
should be interpreted with caution. Regional differences in
AF burden exist, but our observations may not always be a
reliable estimate as a result of the geographical disparity of
data density and nonrepresentative population bias, as well
as estimates based on imputations. However, even though
the need for better estimates, particularly in the developing
world, is crucial, our report likely represents the best available data source for global policy and decision making.
Targeted population surveillance studies of AF could fill the
gaps in data and permit more reliable estimates of burden of
disease in coming decades.
Conclusions
There have been progressive increases in the worldwide prevalence and incidence of AF with significant effects on associated morbidity and mortality, findings that have implications
for public health policy and healthcare costs. Evidence for
geographic variation in AF burden, especially in developing
versus developed nations, indicates that systematic, global
surveillance of AF is required to formulate effective regionspecific prevention and treatment strategies.
Figure 8. Disability-adjusted life-years (DALYs)
related to atrial fibrillation. Estimated age-adjusted
DALYs (per 100 000) related to atrial fibrillation:
1990 to 2010. UI indicates uncertainty index.
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Chugh et al Global Burden of Atrial Fibrillation 845
Sources of Funding
This research was supported by core funding from the Bill & Melinda
Gates Foundation. Dr Chugh holds the Pauline and Harold Price
Endowed Chair of Cardiac Electrophysiology at the Heart Institute,
Cedars-Sinai Medical Center, Los Angeles, CA. Dr Havmoeller
is supported by a grant from the Swedish Research Council (grant
2011-1071). Dr Benjamin is supported by 1R01HL092577,
1R01HL102214, 1RC1HL101056, and 1R01AG028321. Dr Rienstra
is supported by a grant from the Netherlands Organization for
Scientific Research (Veni grant 016.136.055). The funding sources
had no influence over the study or the interpretation of the results.
Disclosures
None.
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Chugh et al Global Burden of Atrial Fibrillation 847
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Clinical Perspective
Atrial fibrillation (AF) is the most common heart rhythm disorder around the world. We report results of the first global
assessment of AF, conducted within the framework of the recently published Global Burden of Diseases, Injuries, and Risk
Factors Study (the GBD 2010 Study). The estimated global prevalence of AF in 2010 was 33.5 million (20.9 million men
and 12.6 million women). Between 1990 and 2010, there were significant increases in the estimated age-adjusted prevalence
and incidence of AF. These increases were accompanied by increases in AF disease burden measured as disability-adjusted
life-years and mortality associated with AF. Our findings indicate progressive increases in the worldwide prevalence and
incidence of AF, as well as associated morbidity and mortality. Systematic, global surveillance of AF is required to better
direct prevention and treatment strategies. As the first assessment of the global burden of AF, these findings have important
implications for public health policy and healthcare costs.
Downloaded from http://circ.ahajournals.org/ at Oregon State University--Corvallis on June 17, 2014
SUPPLEMENTAL METHODS
The diagram shows the process for literature review in the present study. The multiple-phase
screening process generated 184 papers that met eligibility and quality criteria from an initial
4,574 papers identified through data base queries.
Initial search of
databases
N=4,574
Initial screening:
Abstract review
Excluded
N=4,197
Secondary screening:
Excluded
Full text review
N=193
N=377
Final list of papers
selected for abstraction
N=184
Search Methods for Identification of Studies
The following sources were included in the literature search process:
MEDLINE (PubMed) from 1980 to present, Embase from 1980 to present, and LILACS
from 1982 to present. No language limits were applied.
Note: LILACS is a collection of databases containing Latin American and Caribbean
health sciences literature.
MEDLINE was searched using the following strategy:
•
Atrial Fibrillation/Atrial Flutter as a MESH term, with Epidemiology as a subheading,
limited to particular study types, or incidence, prevalence, mortality, case fatality rate:
Strategy: atrial fibrillation (or) atrial flutter/epidemiology[mh] AND (review[pt] OR
guideline[pt] OR study characteristics[pt] OR epidemiologic study characteristics as
topic[mh] OR support of research[pt] OR incidence[mh] OR prevalence[mh] OR
mortality[mh] OR mo[sh] OR "case fatality"[tw])
•
Limits: Publication Date from 1980 to 2010 (1852 citations)
•
Atrial Fibrillation/Atrial Flutter as a MESH term with Epidemiology as a subheading not
limited to particular study types.
•
Strategy: atrial fibrillation (or) atrial flutter/epidemiology[mh] NOT (review[pt] OR
guideline[pt] OR study characteristics[pt] OR epidemiologic study characteristics as
topic[mh] OR support of research[pt] OR incidence[mh] OR prevalence[mh] OR
mortality[mh] OR mo[sh] OR "case fatality"[tw])
Limits: Publication Date from 1980 to 2010 (123 citations)
•
Atrial Fibrillation/Atrial Flutter as a MESH term with Mortality as a subheading, or
Atrial Fibrillation/Atrial Flutter as a MESH term with mortality as a MESH term:
•
Strategy: atrial fibrillation (or) atrial flutter/mortality[mh] OR (atrial fibrillation/atrial
flutter[mh] AND mortality[sh]) Limits: Publication Date from 1980 to 2010 (882
citations)
•
Atrial Fibrillation/Atrial flutter as a word in the title, with epidemiology, incidence,
prevalence, fatality or mortality in the title or abstract, limited to recent unindexed inprocess citations or recent unindexed citations from the publisher:
•
Strategy: (("atrial fibrillation"/”atrial flutter”[ti] AND (epidemiology[tiab] OR
incidence[tiab]OR mortality[tiab] OR prevalence[tiab] OR fatality[tiab])AND(inprocess[sb] OR publisher[sb])) Limits: Publication Date from 1980 to 2010 (132
citations)
•
#1 OR #2 OR #3 OR #4
•
Timespan: 1980-2010
Citations Found: 2989
•
EMBASE was searched using the following strategy:
•
Search for epidemiology and mortality of atrial fibrillation/atrial flutter. Limited to the
years 1980-2010:
•
Strategy: Epidemiology/exp/mj AND heart atrium fibrillation/atrial flutter/exp/mj AND
humans/lim AND 1980-2010/py OR (epidemiology/exp AND (heart atrium
fibrillation/atrial flutter/exp OR atrial fibrillation/exp OR auricular fibrillation/exp AND
1980-2010/py OR (heart atrium fibrillation/atrial flutter/dm_ep AND humans/lim AND
1980-2010/py OR (heart atrium fibrillation:ti OR atrial fibrillation:ti) AND (prevalence:ti
OR incidence:ti OR epidemiology:ti OR morbidity:ti OR mortality:ti) AND humans/lim
AND 1980-2010/py AND embase/lim
•
Timespan 1980-2010
•
Citations Found: 1541
•
LILACS ( http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/ ) was searched using
the following strategy:
•
1. Atrial Fibrillation or Auricular Fibrillation or Fibrilacao Atrial or Atrial Flutter as a
subject descriptor and also as a word in the title or abstract with Epidemiology or
Mortality as a subheading, or Incidence or Prevalence as a title word.
•
Strategy: atrial fibrillation or auricular fibrillation or fibrilação atrial or atrial flutter
[Descritor de assunto] and incidence or prevalence or epidemiology [Palavras do título]
or
•
( ( "ATRIAL FIBRILLATION/EP" ) or "ATRIAL FIBRILLATION/MO" or "ATRIAL
FIBRILLATION/EP" or "AURICULAR FIBRILLATION/EP" or "AURICULAR
FIBRILLATION/MO" ) or "FIBRILACAO ATRIAL/EP" or "FIBRILACAO
ATRIAL/MO" or “ATRIAL FLUTTER/EP” or “ATRIAL FLUTTER/MO”[Descritor de
assunto]
•
Timespan: 1982 to present
•
Citations Found: 44
Summary of Study Eligibility Criteria
Inclusion Criteria
•
Population Level Study[1]
•
Study reports data related to atrial fibrillation prevalence or incidence
•
Only well‐designed studies that were conducted using rigorous research methodology were used. The following
criteria were applied to each paper[2]:
–
Study design and methods are appropriate for research question
–
Sample Size is adequate for robust estimates.
–
For epidemiologic data:
–
•
Denominator data is adequately defined, reliable and sources documented
•
Confidence intervals or variance estimates are reported
For Study Discussion and Conclusions
•
Sources of potential bias are adequately addressed
•
Study limitations are identified.
Exclusion Criteria
•
Studies that were related to Atrial Fibrillation in select clinical sub‐groups (inpatient, heart failure, dialysis) and not
conducted in the general population.
•
[1] Review articles were included if they were likely to contain references that could be used for future data
extraction.
•
[2] In GBD regions with limited available data, exceptions to these criteria will be made so long as two independent
reviewers agreed to include the paper for data extraction.
The final list of studies used for data abstraction
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Clemens A, Plumb JM. Warfarin treatment in patients
with atrial fibrillation: Observing outcomes associated
with varying levels of INR control. Thromb Res 2008
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Chien KL, Su TC, Hsu HC et al. Atrial fibrillation
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death among Chinese. Int J Cardiol 2008 November 29.
Walker AM, Bennett D. Epidemiology and outcomes in
patients with atrial fibrillation in the United States. Heart
Rhythm 2008 October;5(10):1365-72.
Zhou Z, Hu D. An epidemiological study on the
prevalence of atrial fibrillation in the Chinese population
of mainland China. J Epidemiol 2008;18(5):209-16.
Inoue H, Fujiki A, Origasa H et al. Prevalence of atrial
fibrillation in the general population of Japan: An
analysis based on periodic health examination. Int J
Cardiol 2008 August 6.
Ruigomez A, Johansson S, Wallander MA, Edvardsson
N, Garcia Rodriguez LA. Risk of cardiovascular and
cerebrovascular events after atrial fibrillation diagnosis.
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Rietbrock S, Heeley E, Plumb J, van ST. Chronic atrial
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stroke using the Congestive heart failure, Hypertension,
Age >75, Diabetes mellitus, and prior Stroke or transient
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Heart J 2008 July;156(1):57-64.
Gandolfo C, Balestrino M, Burrone A, Del SM, Finocchi
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prescribing anticoagulant prevention in Italy. A
prospective study of a consecutive stroke population
admitted to a comprehensive stroke unit. J Neurol 2008
Cameron AC, Jenkins SM, Dunn FG. The burden of atrial
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Borzecki AM, Bridgers DK, Liebschutz JM, Kader B,
Kazis LE, Berlowitz DR. Racial differences in the
prevalence of atrial fibrillation among males. J Natl Med
Assoc 2008 February;100(2):237-45.
Lip GY, Frison L, Grind M. Stroke event rates in
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J Intern Med 2008 July;264(1):50-61.
Guize L, Thomas F, Bean K, Benetos A, Pannier B.
[Atrial fibrillation: prevalence, risk factors and mortality
in a large French population with 15 years of follow-up].
Bull Acad Natl Med 2007 April;191(4-5):791-803.
Kannel WB, Benjamin EJ. Status of the epidemiology of
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January;92(1):17-40, ix
Dabdoob WA, Bener A, Al-Mohannadi D, Numan MT,
Al-Binali HA, Al-Suwaidi J. Epidemiology of atrial
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Lee CH, Liu PY, Tsai LM et al. Characteristics of
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Cea-Calvo L, Redon J, Lozano JV et al. [Prevalence of
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or more. The PREV-ICTUS study]. Rev Esp Cardiol
2007 June;60(6):616-24.
Hylek EM, Evans-Molina C, Shea C, Henault LE, Regan
S. Major hemorrhage and tolerability of warfarin in the
first year of therapy among elderly patients with atrial
fibrillation. Circulation 2007 May 29;115(21):2689-96.
McDonald AJ, Pelletier AJ, Ellinor PT, Camargo CA, Jr.
Increasing US emergency department visit rates and
subsequent hospital admissions for atrial fibrillation from
1993 to 2004. Ann Emerg Med 2008 January;51(1):58-65.
Suzuki S, Yamashita T, Kato T et al. Incidence of major
bleeding complication of warfarin therapy in Japanese
patients with atrial fibrillation. Circ J 2007
May;71(5):761-5.
Santini M, Ricci RP. The worldwide social burden of
atrial fibrillation: what should be done and where do we
go? J Interv Card Electrophysiol 2006
December;17(3):183-8.
Chen LY, Shen WK. Epidemiology of atrial fibrillation: a
current perspective. Heart Rhythm 2007 March;4(3
Suppl):S1-S6.
Uyarel H, Onat A, Yuksel H, Can G, Ordu S, Dursunoglu
D. [Incidence, prevalence, and mortality estimates for
chronic atrial fibrillation in Turkish adults]. Turk
Kardiyol Dern Ars 2008 June;36(4):214-22.
Miyasaka Y, Barnes ME, Gersh BJ et al. Changing trends
of hospital utilization in patients after their first episode
of atrial fibrillation. Am J Cardiol 2008 September
1;102(5):568-72.
Origasa H, Goto S, Uchiyama S, Shimada K, Ikeda Y.
The Japan Thrombosis Registry for Atrial Fibrillation,
Coronary or Cerebrovascular Events (J-TRACE): a
nation-wide, prospective large cohort study; the study
design. Circ J 2008 June;72(6):991-7.
Suzuki S, Yamashita T, Ohtsuka T et al. Prevalence and
prognosis of patients with atrial fibrillation in Japan: a
prospective cohort of Shinken Database 2004. Circ J
2008 June;72(6):914-20.
Iguchi Y, Kimura K, Aoki J et al. Prevalence of atrial
fibrillation in community-dwelling Japanese aged 40
years or older in Japan: analysis of 41,436 non-employee
residents in Kurashiki-city. Circ J 2008 June;72(6):90913.
Yang JF, Liu B, Liu DG, Luo Y, Fang F. Prevalence and
risk factors of atrial fibrillation in preterminal inpatients
aged 60 years and over. Chin Med J (Engl ) 2008
October;121(20):2046-9.
Lakshminarayan K, Anderson DC, Herzog CA, Qureshi
AI. Clinical epidemiology of atrial fibrillation and related
cerebrovascular events in the United States. Neurologist
2008 May;14(3):143-50.
Fang MC, Go AS, Chang Y et al. Death and disability
from warfarin-associated intracranial and extracranial
hemorrhages. Am J Med 2007 August;120(8):700-5
Yap KB, Ng TP, Ong HY. Low prevalence of atrial
fibrillation in community-dwelling Chinese aged 55 years
or older in Singapore: a population-based study. J
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Reynolds MR, Essebag V, Zimetbaum P, Cohen DJ.
Healthcare resource utilization and costs associated with
recurrent episodes of atrial fibrillation: the FRACTAL
registry. J Cardiovasc Electrophysiol 2007
June;18(6):628-33.
Miyasaka Y, Barnes ME, Bailey KR et al. Mortality
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21-year community-based study. J Am Coll Cardiol 2007
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Frost L, Andersen LV, Vestergaard P, Husted S,
Mortensen LS. Trend in mortality after stroke with atrial
fibrillation. Am J Med 2007 January;120(1):47-53.
Andersen KK, Olsen TS. Reduced poststroke mortality in
patients with stroke and atrial fibrillation treated with
anticoagulants: results from a Danish quality-control
registry of 22,179 patients with ischemic stroke. Stroke
2007 February;38(2):259-63.
Fornari LS, Calderaro D, Nassar IB et al. Misuse of
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frequent, pervasive and persistent. J Thromb
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including China. Int J Cardiol 2007 November
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Burton C, Isles C, Norrie J, Hanson R, Grubb E. The
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DeWilde S, Carey IM, Emmas C, Richards N, Cook DG.
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Rho RW, Page RL. Asymptomatic atrial fibrillation. Prog
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Frost L, Vestergaard P, Mosekilde L, Mortensen LS.
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Go AS. The epidemiology of atrial fibrillation in elderly
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Covariates and external validity of the ensemble model
SUPPLEMENTAL TABLES
Supplemental Table 1a. Estimated age-standardized prevalence rates of Atrial Fibrillation with 95% Uncertainty Intervals (per 100,000) for
all 21 GBD regions for males and females: 2010
Males
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
North America, High Income
GBD Region
925.7(823.2‐1,027.5)
2,138.3(1,902.5‐2,373.3)
1,395.4(1,240.7‐1,549.3)
4.6(3.4‐6.0)
33.6(25.4‐43.1)
54.9(45.2‐67.2)
63.5(52.9‐77.4)
69.4(58.2‐83.3)
88.5(75.5‐103.8)
126.7(108.9‐148.0)
190.1(159.6‐224.0)
340.1(294.8‐392.4)
595.2(508.9‐686.5)
966.9(815.9‐1,124.0)
1,626.2(1,397.9‐1,864.4)
2,644.5(2,232.3‐3,074.9)
4,284.0(3,708.6‐4,866.6)
6,497.3(5,527.0‐7,452.8)
9,012.7(7,796.5‐10,182.2)
12,340.0(10,724.2‐14,148.9)
Latin America, Southern
10,949.4(5,512.6‐20,464.5)
804.6(401.7‐1,483.5)
1,853.6(924.9‐3,419.0)
1,211.7(605.8‐2,233.3)
4.2(1.8‐8.6)
31.0(13.3‐62.8)
51.1(23.9‐102.0)
59.8(28.2‐118.5)
65.7(30.9‐129.2)
82.4(39.5‐159.6)
115.3(56.3‐227.7)
171.0(84.2‐328.8)
305.9(150.7‐588.0)
541.3(269.4‐1,025.4)
887.5(439.3‐1,693.3)
1,470.4(728.3‐2,826.6)
2,347.0(1,150.0‐4,449.9)
3,640.5(1,799.5‐6,963.4)
5,353.5(2,590.5‐10,303.7)
7,442.2(3,709.7‐14,220.9)
Europe, Western
593.2(521.7‐705.9)
1,365.9(1,202.9‐1,623.1)
892.5(785.4‐1,061.6)
3.4(2.4‐4.7)
24.5(17.8‐33.4)
40.1(32.1‐51.7)
46.4(37.3‐57.7)
49.5(39.9‐61.3)
60.0(49.6‐74.1)
81.3(68.2‐99.3)
116.3(96.3‐143.2)
204.4(174.0‐243.2)
359.5(303.6‐432.0)
596.7(494.7‐723.2)
1,052.0(890.3‐1,277.5)
1,768.9(1,471.2‐2,175.9)
2,827.3(2,435.3‐3,356.0)
4,150.9(3,519.4‐4,950.9)
5,791.2(4,930.9‐7,006.1)
7,671.3(6,548.4‐9,387.9)
Australasia
743.3(626.8‐915.8)
1,709.3(1,437.3‐2,109.7)
1,118.3(940.6‐1,380.0)
4.2(2.8‐5.9)
30.5(21.5‐43.0)
50.1(37.8‐66.8)
58.3(44.4‐75.9)
63.8(49.1‐81.6)
78.8(63.1‐98.8)
108.1(86.8‐132.2)
157.5(123.2‐197.0)
281.6(229.3‐351.4)
498.6(394.5‐630.9)
817.2(636.5‐1,036.7)
1,368.9(1,098.3‐1,711.6)
2,192.7(1,705.2‐2,789.7)
3,383.6(2,709.6‐4,271.4)
4,929.6(3,825.5‐6,423.8)
6,836.9(5,371.5‐8,676.4)
9,981.7(8,061.7‐12,404.8)
Asia Pacific, High Income
340.2(304.3‐381.3)
784.3(700.2‐880.4)
512.5(458.4‐574.1)
1.8(1.3‐2.3)
12.8(9.3‐16.6)
21.0(16.9‐25.6)
24.7(20.4‐29.8)
27.6(23.2‐33.4)
34.6(29.5‐41.2)
48.1(40.5‐56.5)
71.1(59.1‐85.1)
130.1(112.0‐150.4)
237.2(203.0‐272.4)
400.0(338.6‐463.9)
683.0(599.0‐776.0)
1,100.6(945.8‐1,275.9)
1,606.7(1,394.8‐1,841.8)
2,186.7(1,887.5‐2,505.8)
2,847.3(2,468.6‐3,271.2)
4,356.1(3,761.3‐5,004.9)
Europe, Eastern
664.9(359.9‐1,204.7)
1,519.2(822.1‐2,777.7)
997.2(540.5‐1,814.7)
4.3(1.8‐8.7)
32.0(13.5‐62.8)
53.3(26.0‐97.5)
62.0(31.1‐111.6)
66.7(33.7‐124.2)
79.0(39.6‐147.0)
103.9(53.1‐191.4)
147.5(74.1‐272.8)
257.5(134.1‐464.1)
453.2(238.4‐825.3)
739.8(386.7‐1,347.9)
1,200.3(623.8‐2,193.4)
1,877.1(960.0‐3,487.1)
2,887.6(1,533.1‐5,195.5)
4,222.0(2,202.3‐7,701.1)
5,853.5(3,099.7‐10,689.4)
9,634.8(5,127.7‐17,778.3)
Europe, Central
795.4(545.4‐1,143.4)
1,830.3(1,250.5‐2,639.3)
1,196.9(820.7‐1,721.4)
4.4(2.4‐6.9)
31.9(18.1‐50.3)
52.9(32.4‐80.8)
62.0(37.9‐95.4)
67.6(42.6‐103.3)
83.2(54.3‐125.3)
113.2(75.1‐167.8)
164.9(107.9‐245.0)
293.4(194.7‐414.5)
527.0(347.4‐767.8)
870.2(556.5‐1,304.9)
1,435.9(928.4‐2,077.4)
2,282.5(1,419.0‐3,366.7)
3,543.1(2,270.3‐5,142.3)
5,233.9(3,397.9‐7,995.1)
7,315.7(4,838.6‐11,033.8)
11,264.3(7,469.8‐16,238.0)
662.8(439.9‐977.9)
1,510.8(1,002.5‐2,224.6)
993.3(658.6‐1,464.8)
4.4(2.1‐7.5)
32.5(16.5‐56.0)
55.5(31.8‐90.2)
65.5(38.3‐103.5)
70.4(42.8‐111.2)
82.7(51.3‐126.5)
108.3(66.4‐162.8)
154.2(93.0‐233.1)
278.4(176.5‐413.1)
503.8(324.8‐749.2)
830.9(520.1‐1,253.5)
1,308.1(836.8‐1,986.4)
1,963.0(1,218.1‐3,038.7)
2,886.5(1,852.7‐4,390.8)
4,073.1(2,594.5‐6,140.2)
5,508.1(3,601.4‐8,128.5)
8,785.7(5,858.7‐12,741.2)
Sub‐Saharan Africa, West
635.5(400.8‐1,019.4)
1,453.6(916.3‐2,344.6)
953.6(600.8‐1,531.8)
4.0(2.0‐7.1)
29.5(15.0‐51.8)
49.4(28.3‐80.8)
57.9(34.1‐94.6)
62.8(36.7‐103.5)
74.3(44.4‐119.5)
97.2(58.8‐157.5)
136.6(83.9‐217.1)
236.2(151.8‐373.0)
415.6(259.9‐664.2)
684.3(416.1‐1,109.8)
1,130.4(701.6‐1,825.8)
1,800.6(1,086.4‐2,929.8)
2,768.1(1,669.6‐4,542.0)
4,064.0(2,468.9‐6,747.3)
5,747.4(3,483.4‐9,435.9)
9,291.4(5,549.1‐14,978.6)
Sub‐Saharan Africa, Southern
804.8(400.5‐1,528.9)
1,849.4(923.3‐3,512.6)
1,210.3(602.1‐2,301.9)
4.6(2.1‐8.8)
33.6(15.6‐64.2)
55.6(26.7‐103.6)
65.0(32.1‐121.7)
70.8(34.9‐132.3)
86.2(42.3‐161.3)
117.0(56.7‐222.4)
169.8(80.0‐324.1)
298.7(139.3‐576.5)
528.1(239.2‐1,008.9)
869.9(391.2‐1,668.7)
1,441.8(669.5‐2,695.2)
2,307.4(1,065.4‐4,507.9)
3,574.3(1,715.9‐7,070.9)
5,260.6(2,591.4‐10,148.7)
7,397.6(3,778.3‐13,400.3)
11,479.2(5,881.7‐21,058.8)
643.5(460.8‐917.3)
1,470.7(1,047.4‐2,110.4)
965.2(689.2‐1,378.9)
4.1(2.1‐6.6)
30.6(16.2‐47.8)
51.5(32.6‐76.7)
60.3(37.9‐90.1)
64.8(42.2‐94.9)
76.1(51.6‐109.3)
99.1(68.2‐137.5)
139.0(94.3‐197.6)
240.0(164.2‐341.1)
422.0(289.4‐609.7)
695.5(469.3‐1,020.9)
1,149.4(791.8‐1,680.5)
1,829.4(1,250.7‐2,767.0)
2,810.8(1,910.5‐4,151.2)
4,124.7(2,777.8‐5,971.9)
5,802.0(4,023.2‐8,249.3)
9,313.1(6,452.7‐13,230.2)
Sub‐Saharan Africa, Central
676.1(370.1‐1,263.3)
1,549.1(844.9‐2,896.2)
1,015.1(554.6‐1,899.1)
4.1(1.7‐8.1)
30.3(13.1‐59.7)
50.9(23.8‐98.3)
59.7(28.3‐116.6)
64.5(30.8‐123.8)
76.3(37.2‐141.5)
99.9(50.4‐189.6)
140.9(70.6‐266.1)
245.1(128.6‐448.4)
433.2(226.1‐817.2)
716.5(362.6‐1,365.7)
1,193.2(625.1‐2,249.4)
1,915.3(985.1‐3,613.6)
2,965.6(1,560.1‐5,649.5)
4,372.1(2,270.4‐8,210.0)
6,181.0(3,315.9‐11,353.2)
9,932.4(5,700.8‐17,900.1)
North Africa / Middle East
676.2(502.5‐924.8)
1,555.8(1,157.5‐2,131.0)
1,017.4(756.0‐1,390.0)
3.8(2.5‐5.6)
27.8(18.3‐40.4)
45.4(32.0‐62.4)
52.4(37.6‐71.5)
57.0(41.9‐77.0)
70.4(52.8‐92.4)
96.9(72.5‐127.3)
141.9(104.0‐191.5)
251.5(184.5‐338.2)
444.9(325.6‐625.2)
731.7(520.7‐1,029.1)
1,209.1(873.6‐1,694.9)
1,930.4(1,330.9‐2,801.9)
3,017.3(2,135.3‐4,219.7)
4,476.8(3,197.3‐6,258.2)
6,281.7(4,554.1‐8,644.2)
9,541.6(7,191.6‐12,893.0)
Asia, Central
Sub‐Saharan Africa, East
Asia, South
550.9(474.4‐657.0)
1,266.1(1,086.4‐1,514.1)
828.3(712.2‐988.3)
3.2(2.2‐4.3)
23.1(16.3‐30.7)
38.3(30.5‐48.3)
44.6(36.1‐56.2)
48.4(39.1‐60.3)
58.5(48.6‐71.6)
78.7(64.6‐96.0)
113.6(92.5‐140.7)
201.8(168.2‐245.6)
359.5(294.8‐441.3)
594.8(480.6‐736.1)
981.1(819.1‐1,190.6)
1,565.3(1,275.5‐1,927.6)
2,418.7(2,008.1‐2,974.1)
3,551.3(2,943.7‐4,397.9)
4,992.0(4,152.3‐6,242.5)
8,148.1(6,741.5‐10,129.4)
648.2(360.9‐1,168.9)
1,477.3(824.2‐2,649.7)
970.6(540.3‐1,746.5)
4.6(2.1‐9.5)
33.6(15.4‐68.8)
56.5(26.6‐111.2)
64.3(30.8‐123.0)
65.1(31.8‐125.2)
78.3(39.1‐149.5)
107.5(54.7‐211.1)
156.6(75.5‐304.5)
299.7(154.6‐582.0)
536.3(266.4‐1,042.1)
851.4(429.8‐1,639.9)
1,395.1(707.4‐2,609.7)
2,139.9(1,114.2‐4,069.9)
3,150.7(1,664.3‐5,958.3)
4,203.0(2,177.4‐7,867.3)
5,220.4(2,864.9‐9,226.1)
6,439.6(3,681.8‐11,072.2)
Asia, Southeast
571.3(370.8‐840.6)
1,309.3(847.4‐1,938.2)
858.2(556.0‐1,266.9)
3.5(1.9‐5.8)
25.6(14.2‐41.3)
42.2(25.8‐65.1)
49.1(30.7‐75.3)
53.2(33.1‐81.2)
64.5(40.8‐97.2)
87.4(54.4‐133.7)
126.9(78.0‐200.1)
222.4(138.1‐348.1)
391.1(244.1‐612.2)
640.5(396.7‐999.3)
1,042.1(665.8‐1,574.8)
1,637.1(1,021.5‐2,507.9)
2,495.1(1,556.6‐3,877.9)
3,625.4(2,212.9‐5,597.7)
5,059.6(3,144.1‐7,685.9)
8,210.5(5,141.1‐12,427.7)
Asia, East
472.1(433.0‐516.5)
1,082.7(989.5‐1,188.1)
709.3(649.8‐777.4)
2.9(2.0‐3.9)
21.1(15.2‐27.5)
34.4(27.9‐41.5)
39.8(32.6‐48.2)
42.9(35.8‐52.2)
52.1(44.4‐61.9)
71.4(60.9‐84.2)
104.1(87.2‐124.4)
179.9(155.6‐208.2)
313.2(266.6‐363.5)
514.5(431.3‐607.7)
833.3(720.2‐957.3)
1,304.7(1,095.7‐1,529.5)
2,032.2(1,758.4‐2,341.3)
3,035.7(2,590.1‐3,531.2)
4,288.6(3,693.0‐4,971.3)
7,013.8(6,122.5‐8,062.6)
Latin America, Tropical
696.8(625.6‐780.5)
1,605.5(1,434.2‐1,804.1)
1,049.0(939.7‐1,175.5)
3.8(2.7‐5.1)
27.4(19.6‐36.4)
45.1(36.9‐55.4)
52.9(43.1‐63.9)
57.7(47.4‐70.3)
70.5(59.7‐84.5)
95.8(80.9‐113.0)
139.5(115.2‐169.2)
248.7(210.6‐291.4)
441.3(369.0‐526.3)
727.8(596.9‐878.5)
1,211.9(1,017.5‐1,426.1)
1,944.8(1,583.9‐2,391.0)
3,047.3(2,554.1‐3,655.2)
4,545.2(3,717.1‐5,504.0)
6,494.1(5,460.8‐7,688.6)
10,546.3(9,108.3‐12,293.7)
Latin America, Central
698.1(404.6‐1,152.3)
1,599.2(924.9‐2,642.0)
1,048.2(606.5‐1,730.7)
4.4(2.2‐7.8)
31.7(16.7‐55.9)
52.7(29.9‐87.4)
61.7(34.4‐104.7)
66.6(37.2‐111.6)
79.2(46.2‐130.0)
104.8(60.5‐173.3)
148.9(84.4‐256.8)
259.0(148.5‐439.1)
456.2(268.8‐775.5)
751.0(426.6‐1,281.0)
1,235.7(708.1‐2,058.4)
1,961.9(1,094.5‐3,239.8)
3,035.2(1,726.5‐5,103.7)
4,479.5(2,579.9‐7,550.1)
6,307.7(3,636.0‐10,782.4)
10,335.8(6,019.6‐17,355.4)
Latin America, Andean
750.1(409.2‐1,320.8)
1,722.2(933.7‐3,053.5)
1,127.3(613.9‐1,991.7)
4.5(2.1‐8.4)
32.5(15.7‐60.1)
53.5(28.3‐95.0)
62.3(33.8‐109.4)
67.7(36.4‐120.8)
81.4(43.9‐149.3)
108.7(58.3‐199.2)
155.6(83.4‐279.2)
273.1(150.4‐490.2)
483.4(251.3‐875.3)
798.6(405.5‐1,454.8)
1,322.4(682.0‐2,380.7)
2,112.0(1,089.8‐3,818.0)
3,268.2(1,693.4‐5,982.0)
4,822.1(2,502.7‐8,710.1)
6,824.3(3,560.8‐12,205.5)
11,244.2(6,045.9‐19,874.8)
Caribbean
868.4(526.8‐1,400.2)
1,996.8(1,202.4‐3,242.1)
1,306.5(790.5‐2,110.5)
4.9(2.6‐8.4)
35.5(19.4‐59.9)
58.6(35.2‐93.3)
68.5(41.5‐111.3)
74.7(45.1‐119.7)
92.0(56.9‐146.2)
126.9(78.1‐201.2)
187.1(113.9‐304.2)
336.5(205.4‐535.2)
597.8(361.1‐974.7)
983.6(598.0‐1,582.9)
1,640.4(997.6‐2,634.3)
2,616.5(1,540.4‐4,310.3)
4,028.0(2,381.9‐6,621.0)
5,815.4(3,417.4‐9,826.9)
7,906.6(4,728.1‐13,495.4)
11,039.9(6,527.2‐19,274.0)
Developed
660.9(597.1‐738.2)
1,518.8(1,372.7‐1,697.3)
993.9(898.2‐1,111.4)
3.9(3.1‐4.7)
27.9(23.1‐33.7)
45.3(38.9‐53.0)
53.0(45.5‐62.8)
57.9(49.0‐70.6)
70.8(60.7‐84.8)
96.0(83.8‐113.0)
137.9(120.9‐160.6)
245.2(217.9‐278.7)
437.9(386.0‐503.9)
725.2(634.8‐845.2)
1,217.5(1,076.4‐1,396.8)
1,947.5(1,730.2‐2,219.1)
3,039.2(2,750.2‐3,383.5)
4,410.5(3,905.6‐5,059.3)
6,110.8(5,477.7‐6,866.7)
8,778.3(7,919.9‐9,773.8)
Developing
565.7(522.9‐617.6)
1,296.3(1,197.7‐1,413.9)
849.5(785.2‐926.5)
3.6(3.0‐4.2)
25.9(22.2‐30.0)
42.4(37.8‐47.9)
49.1(44.0‐55.2)
52.7(47.3‐59.1)
63.8(57.9‐71.0)
85.8(77.4‐95.8)
121.9(109.7‐136.0)
211.7(192.9‐233.9)
375.7(341.8‐416.4)
616.8(557.5‐686.5)
998.4(911.1‐1,100.9)
1,588.5(1,439.6‐1,760.2)
2,466.1(2,236.5‐2,725.6)
3,633.4(3,292.8‐4,018.4)
5,107.9(4,667.8‐5,643.3)
8,316.2(7,588.5‐9,169.2)
Global
596.2(558.4‐636.7)
1,368.5(1,280.8‐1,462.7)
895.9(839.3‐957.3)
3.6(3.1‐4.1)
26.1(22.9‐29.7)
42.7(38.5‐47.6)
49.6(44.9‐54.9)
53.5(48.5‐58.9)
64.9(59.6‐71.1)
87.6(80.5‐95.9)
124.8(114.5‐136.6)
218.3(202.3‐236.4)
390.1(360.0‐424.3)
644.3(590.9‐703.2)
1,055.7(974.4‐1,142.0)
1,699.6(1,565.7‐1,845.4)
2,645.6(2,449.3‐2,858.0)
3,905.6(3,615.4‐4,222.6)
5,485.7(5,106.1‐5,899.7)
8,530.4(7,935.5‐9,186.3)
Females
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
North America, High Income
520.8(463.0‐588.5)
1,198.9(1,064.5‐1,361.0)
783.7(696.7‐887.3)
2.9(2.1‐3.8)
21.1(15.7‐27.0)
34.7(28.1‐42.1)
39.8(32.3‐48.0)
42.5(34.7‐51.1)
53.2(44.7‐62.2)
75.0(63.2‐87.6)
111.2(92.8‐131.8)
199.4(171.3‐231.3)
347.5(294.4‐407.1)
558.9(465.8‐663.0)
931.8(793.2‐1,082.6)
1,494.3(1,261.8‐1,767.9)
2,389.2(2,042.9‐2,775.2)
3,561.7(2,985.9‐4,248.2)
4,988.1(4,267.9‐5,833.6)
6,865.1(5,967.8‐7,932.2)
Latin America, Southern
455.9(235.8‐845.8)
1,048.3(542.7‐1,958.9)
685.9(354.9‐1,276.6)
2.6(1.2‐5.0)
18.5(8.5‐37.2)
30.7(14.7‐58.4)
36.0(17.4‐69.9)
39.2(19.2‐74.9)
48.5(24.2‐94.5)
67.0(33.2‐131.5)
98.4(48.9‐184.2)
177.6(89.1‐329.1)
316.5(156.9‐575.9)
519.5(255.3‐965.3)
856.8(430.6‐1,575.0)
1,357.5(676.5‐2,529.3)
2,097.4(1,062.6‐3,963.6)
3,061.0(1,519.8‐5,833.5)
4,185.6(2,124.2‐8,115.2)
5,809.6(2,946.2‐11,234.7)
Europe, Western
359.1(311.1‐426.0)
824.8(714.6‐982.6)
539.4(467.6‐640.6)
2.3(1.6‐3.0)
16.1(11.5‐21.4)
26.5(21.2‐33.1)
30.3(24.2‐38.2)
31.5(25.4‐39.8)
37.4(30.9‐46.0)
49.9(41.4‐60.1)
70.5(57.6‐86.5)
124.4(104.8‐149.5)
217.7(182.6‐268.0)
355.6(292.5‐444.9)
614.2(515.9‐749.5)
1,012.6(824.3‐1,264.0)
1,631.0(1,374.1‐1,949.1)
2,427.1(2,024.3‐2,986.0)
3,606.5(3,060.3‐4,391.9)
4,997.2(4,190.1‐6,030.7)
Australasia
439.0(372.3‐537.3)
1,007.7(852.5‐1,237.1)
659.8(559.3‐807.9)
2.6(1.8‐3.7)
19.2(13.1‐26.8)
31.5(24.2‐41.5)
36.4(28.0‐48.4)
39.2(30.5‐51.7)
47.9(38.5‐61.3)
65.2(52.4‐83.4)
94.4(75.1‐123.1)
171.9(139.4‐218.7)
306.7(242.9‐395.9)
501.1(394.1‐656.8)
836.2(676.4‐1,070.4)
1,326.5(1,008.3‐1,754.6)
2,030.7(1,589.3‐2,591.4)
2,905.9(2,196.6‐3,786.1)
3,925.1(3,154.9‐4,989.2)
5,597.8(4,588.8‐7,021.1)
Asia Pacific, High Income
196.0(176.7‐220.1)
451.0(406.1‐507.4)
295.0(265.7‐331.6)
1.1(0.8‐1.5)
8.0(6.1‐10.2)
12.9(10.6‐15.7)
15.1(12.7‐18.1)
16.7(14.0‐19.8)
20.7(17.6‐24.3)
28.0(24.2‐32.5)
40.7(34.7‐48.3)
75.0(65.8‐85.9)
137.9(120.2‐157.9)
232.8(200.1‐269.3)
387.6(341.9‐441.4)
610.2(529.1‐716.8)
895.5(781.5‐1,033.5)
1,242.6(1,067.5‐1,452.3)
1,657.5(1,441.7‐1,931.4)
2,617.1(2,292.2‐3,003.3)
Europe, Eastern
399.8(199.4‐756.1)
917.3(457.9‐1,729.7)
600.6(299.7‐1,133.2)
2.4(1.1‐5.0)
17.8(8.1‐35.8)
29.5(14.7‐57.8)
34.2(17.2‐66.7)
36.8(18.5‐72.7)
43.7(21.8‐86.3)
57.5(29.0‐112.2)
81.8(41.5‐158.6)
145.4(73.0‐281.3)
259.7(131.4‐517.4)
428.5(208.9‐862.4)
705.1(349.8‐1,420.2)
1,117.1(537.3‐2,231.7)
1,737.8(859.1‐3,271.1)
2,551.1(1,223.9‐4,848.8)
3,572.0(1,775.5‐6,783.2)
6,086.4(3,078.7‐11,459.5)
Europe, Central
463.3(316.2‐677.4)
1,063.7(720.4‐1,560.2)
696.4(472.5‐1,019.4)
2.8(1.4‐4.7)
20.2(10.8‐33.5)
33.0(19.2‐53.2)
38.3(23.0‐61.3)
41.5(25.2‐66.7)
50.5(31.4‐80.3)
67.6(43.4‐103.9)
97.2(62.0‐149.7)
171.6(113.2‐253.0)
308.3(199.3‐460.8)
508.3(317.5‐773.8)
838.1(533.2‐1,285.9)
1,331.3(824.0‐2,074.9)
2,066.3(1,331.0‐3,095.3)
3,045.0(1,937.9‐4,654.5)
4,246.8(2,742.0‐6,510.4)
6,481.8(4,264.8‐10,005.0)
Asia, Central
359.3(245.7‐527.6)
816.4(557.2‐1,203.0)
537.6(368.0‐791.4)
2.5(1.1‐4.6)
18.8(9.1‐34.2)
32.3(18.8‐52.9)
38.2(22.4‐61.0)
40.9(24.6‐64.7)
47.2(29.6‐72.1)
60.2(38.9‐93.1)
83.1(53.9‐130.3)
142.0(93.0‐214.8)
247.2(158.6‐377.9)
404.4(252.5‐617.4)
675.4(440.2‐1,000.9)
1,086.4(702.9‐1,653.0)
1,635.5(1,062.1‐2,486.9)
2,274.4(1,467.4‐3,514.7)
3,023.2(2,012.5‐4,546.9)
4,774.0(3,192.8‐7,101.7)
Sub‐Saharan Africa, West
445.1(279.9‐710.7)
1,021.2(637.4‐1,638.0)
668.9(420.1‐1,070.2)
2.6(1.3‐4.8)
19.2(10.2‐34.9)
32.2(18.6‐55.2)
37.7(22.5‐64.8)
41.1(24.9‐70.5)
49.3(30.0‐83.4)
65.6(40.2‐110.5)
93.4(57.9‐157.6)
164.1(105.3‐260.6)
291.1(182.6‐478.8)
481.2(289.5‐806.6)
799.1(494.8‐1,310.9)
1,278.7(766.9‐2,128.0)
1,978.0(1,205.6‐3,250.7)
2,909.6(1,752.4‐4,809.5)
4,084.1(2,468.0‐6,600.2)
6,308.4(3,692.0‐10,583.2)
Sub‐Saharan Africa, Southern
493.1(245.8‐934.5)
1,132.4(562.4‐2,154.9)
741.4(368.7‐1,406.2)
2.9(1.3‐5.9)
20.7(9.5‐42.6)
34.4(16.5‐69.7)
40.2(19.2‐78.7)
43.6(20.9‐85.0)
53.4(26.3‐101.8)
73.3(36.7‐138.2)
107.6(52.3‐213.4)
192.7(91.6‐382.0)
342.0(163.4‐662.8)
561.3(268.0‐1,094.0)
931.7(445.6‐1,851.4)
1,488.5(704.6‐3,041.9)
2,287.3(1,106.6‐4,570.0)
3,301.3(1,602.2‐6,457.3)
4,505.6(2,176.1‐8,763.5)
6,172.5(2,987.7‐11,850.8)
Sub‐Saharan Africa, East
413.8(288.8‐575.6)
949.8(658.5‐1,326.7)
621.9(432.7‐864.3)
2.5(1.4‐3.9)
17.9(10.2‐28.7)
29.8(19.1‐45.2)
34.8(22.9‐53.5)
37.8(25.3‐58.1)
45.3(30.8‐68.3)
60.1(41.5‐85.9)
85.5(59.1‐125.5)
149.9(103.5‐212.6)
266.0(180.2‐386.3)
440.5(300.0‐643.3)
733.7(497.5‐1,060.0)
1,177.1(787.9‐1,732.1)
1,827.3(1,226.8‐2,693.0)
2,704.8(1,806.0‐3,957.3)
3,808.1(2,570.0‐5,507.1)
6,005.1(4,146.1‐8,575.6)
Sub‐Saharan Africa, Central
445.2(232.8‐810.8)
1,021.7(532.1‐1,867.7)
669.0(348.6‐1,221.2)
2.6(1.1‐5.0)
19.0(8.6‐37.0)
31.8(15.5‐61.8)
37.3(18.3‐74.3)
40.6(19.9‐78.7)
48.8(24.5‐94.2)
65.4(33.6‐126.1)
93.8(48.5‐177.4)
165.0(85.2‐306.0)
292.4(152.3‐539.7)
482.7(251.9‐870.5)
799.0(412.7‐1,453.6)
1,274.9(635.0‐2,324.9)
1,974.4(991.7‐3,541.5)
2,913.3(1,530.6‐5,357.7)
4,090.3(2,140.7‐7,476.1)
6,311.5(3,402.1‐11,333.3)
North Africa / Middle East
411.5(307.7‐556.4)
947.3(708.7‐1,282.3)
619.2(464.0‐838.1)
2.3(1.6‐3.4)
16.8(11.3‐24.4)
27.6(19.9‐38.8)
31.9(22.8‐44.0)
34.5(25.0‐47.1)
42.1(31.8‐57.4)
57.5(43.6‐77.8)
83.9(61.8‐114.0)
150.3(110.2‐204.4)
267.7(193.7‐372.0)
441.4(316.1‐613.7)
733.4(533.6‐999.3)
1,176.1(837.3‐1,649.8)
1,864.3(1,351.6‐2,583.9)
2,792.1(1,994.8‐3,860.2)
3,888.7(2,776.3‐5,466.4)
5,655.4(4,092.1‐7,743.3)
Asia, South
350.5(303.0‐414.6)
806.1(695.0‐957.5)
527.2(455.3‐624.3)
2.0(1.4‐2.8)
14.6(10.4‐19.7)
23.9(18.8‐30.7)
27.7(21.5‐35.2)
30.2(23.5‐38.3)
36.8(29.7‐45.9)
50.0(41.0‐62.5)
72.5(58.7‐91.8)
128.6(107.1‐155.9)
228.2(185.8‐284.0)
376.3(304.3‐473.6)
623.3(514.0‐750.0)
1,000.2(807.5‐1,253.0)
1,555.2(1,280.5‐1,951.3)
2,289.1(1,866.4‐2,854.6)
3,218.4(2,682.8‐3,933.7)
5,080.9(4,264.8‐6,113.2)
Oceania
GBD Region
Oceania
380.8(206.7‐687.8)
867.3(471.7‐1,569.1)
570.1(309.8‐1,031.3)
2.8(1.2‐5.5)
20.0(9.1‐39.6)
33.6(16.3‐64.9)
38.3(18.7‐74.1)
38.9(18.8‐74.1)
46.8(23.4‐88.4)
64.1(32.6‐120.0)
93.0(45.5‐177.3)
175.1(90.7‐330.3)
311.1(157.1‐599.1)
493.6(249.2‐951.2)
812.2(429.3‐1,492.6)
1,251.8(635.9‐2,315.4)
1,843.5(957.5‐3,464.9)
2,462.8(1,214.7‐4,820.8)
3,077.7(1,585.6‐5,750.5)
3,852.3(2,045.3‐7,172.7)
Asia, Southeast
362.3(223.5‐562.4)
832.0(513.7‐1,291.3)
544.6(336.2‐845.3)
2.2(1.2‐3.6)
15.7(8.7‐25.3)
25.7(15.7‐39.9)
29.9(18.3‐46.3)
32.6(19.8‐50.4)
39.3(24.0‐62.4)
52.4(32.5‐85.3)
75.0(46.2‐119.5)
132.1(83.3‐207.4)
234.5(142.8‐368.2)
387.4(233.0‐604.6)
640.3(395.2‐1,001.2)
1,023.2(612.8‐1,620.2)
1,586.0(943.8‐2,625.3)
2,335.7(1,383.9‐3,773.1)
3,291.5(1,958.6‐5,234.8)
5,392.7(3,237.8‐8,363.5)
Asia, East
325.4(297.2‐354.1)
748.1(680.4‐819.3)
489.5(446.4‐533.9)
1.9(1.3‐2.4)
13.4(9.7‐17.1)
22.0(17.8‐27.0)
25.7(21.1‐31.4)
28.0(23.4‐34.1)
34.4(29.1‐40.7)
47.4(39.9‐55.6)
69.4(58.0‐82.8)
122.6(106.4‐140.5)
217.1(185.7‐251.1)
359.1(299.8‐425.7)
580.9(501.7‐671.0)
903.5(762.1‐1,062.1)
1,406.9(1,211.4‐1,628.3)
2,107.3(1,787.0‐2,464.4)
3,033.3(2,619.0‐3,450.6)
4,740.4(4,092.1‐5,420.0)
Latin America, Tropical
426.0(382.7‐471.3)
980.9(878.9‐1,089.1)
641.1(575.5‐710.0)
2.4(1.7‐3.1)
16.8(12.0‐22.0)
27.8(22.3‐33.6)
32.7(26.5‐39.9)
35.8(29.5‐43.6)
43.7(36.8‐51.9)
59.1(49.4‐69.8)
85.6(70.3‐104.9)
153.5(130.1‐178.2)
273.6(228.7‐323.1)
451.4(368.8‐545.6)
752.7(629.7‐882.1)
1,206.2(985.4‐1,451.2)
1,878.0(1,575.4‐2,187.8)
2,772.4(2,241.7‐3,335.0)
3,960.7(3,280.3‐4,696.8)
6,297.0(5,282.2‐7,385.2)
Latin America, Central
419.2(253.2‐697.6)
961.5(578.9‐1,607.0)
629.6(380.1‐1,050.4)
2.6(1.4‐4.6)
18.7(10.1‐32.7)
30.8(17.6‐51.1)
35.9(20.8‐60.8)
38.8(22.5‐65.6)
46.1(27.1‐76.8)
60.7(35.5‐101.5)
86.0(49.2‐147.4)
150.9(87.1‐255.7)
268.0(155.1‐460.5)
444.8(253.5‐753.7)
741.6(442.9‐1,276.6)
1,189.9(684.3‐2,089.9)
1,837.4(1,071.7‐3,090.2)
2,695.1(1,544.6‐4,470.1)
3,789.9(2,225.3‐6,439.9)
6,255.6(3,708.8‐10,592.3)
Latin America, Andean
460.0(247.4‐783.2)
1,056.4(564.5‐1,799.7)
691.5(371.3‐1,176.8)
2.7(1.3‐5.1)
19.5(9.9‐35.9)
32.5(17.6‐57.5)
38.1(20.1‐67.3)
41.3(21.9‐72.3)
49.7(26.2‐86.7)
66.4(35.3‐117.7)
95.1(51.1‐167.3)
167.8(90.8‐289.7)
297.9(160.7‐528.9)
492.8(260.7‐884.7)
819.7(436.0‐1,416.4)
1,313.9(691.1‐2,299.4)
2,036.5(1,061.5‐3,541.3)
2,999.1(1,542.8‐5,145.8)
4,217.0(2,186.9‐7,244.4)
6,658.1(3,413.7‐11,510.2)
Caribbean
481.2(290.6‐765.7)
1,103.7(662.7‐1,760.7)
723.1(435.6‐1,151.0)
2.9(1.5‐5.2)
20.9(11.4‐36.2)
34.7(20.3‐56.6)
40.4(24.1‐64.2)
43.8(26.8‐68.9)
53.5(33.1‐84.4)
72.8(44.7‐114.7)
106.0(62.7‐167.9)
192.3(114.6‐303.9)
342.9(200.2‐556.1)
563.3(332.3‐902.7)
934.8(556.0‐1,488.6)
1,478.4(863.5‐2,413.8)
2,264.8(1,300.3‐3,672.7)
3,228.7(1,830.6‐5,361.0)
4,305.4(2,504.4‐7,033.1)
5,748.8(3,409.8‐9,493.8)
Developed
387.7(343.8‐450.0)
889.6(788.4‐1,031.9)
582.4(516.4‐675.7)
2.4(2.0‐2.9)
17.4(14.4‐20.8)
28.3(24.2‐33.0)
32.8(27.9‐38.6)
35.1(29.6‐42.4)
42.3(36.3‐51.0)
56.7(49.4‐66.7)
80.8(69.9‐94.7)
144.7(127.9‐166.7)
258.5(226.5‐303.5)
425.4(368.0‐506.5)
708.4(616.0‐846.5)
1,120.3(971.1‐1,327.8)
1,744.3(1,544.7‐1,993.5)
2,544.7(2,187.1‐3,062.6)
3,608.9(3,154.2‐4,177.9)
5,288.0(4,657.4‐6,130.9)
Developing
366.1(337.4‐400.8)
840.3(773.2‐919.0)
550.2(506.7‐601.9)
2.2(1.9‐2.6)
16.1(13.9‐18.5)
26.4(23.3‐29.9)
30.5(27.1‐34.4)
32.9(29.3‐36.9)
39.9(35.8‐44.5)
53.8(48.4‐59.9)
76.8(68.8‐86.0)
135.2(122.9‐150.5)
240.8(217.5‐267.6)
397.5(357.1‐445.0)
650.7(590.9‐726.0)
1,037.1(934.4‐1,161.0)
1,617.2(1,476.6‐1,790.9)
2,385.1(2,147.3‐2,643.8)
3,363.6(3,044.0‐3,717.6)
5,268.2(4,775.9‐5,805.3)
Global
373.1(347.9‐402.2)
856.8(797.7‐923.5)
560.8(522.4‐604.4)
2.3(2.0‐2.6)
16.3(14.3‐18.5)
26.6(23.9‐29.6)
30.8(27.7‐34.0)
33.2(30.0‐36.6)
40.3(36.6‐44.2)
54.3(49.7‐59.2)
77.6(70.9‐85.3)
137.1(126.8‐149.6)
245.0(224.7‐268.0)
404.9(368.8‐443.8)
666.7(613.9‐726.9)
1,064.1(975.2‐1,164.5)
1,659.4(1,537.5‐1,796.5)
2,446.3(2,229.2‐2,674.6)
3,465.9(3,200.6‐3,773.2)
5,279.1(4,858.2‐5,783.9)
Supplemental Table 1b. Estimated age-standardized prevalence rates of Atrial Fibrillation with 95% Uncertainty Intervals (per 100,000) for
all 21 GBD regions for males and females: 1990.
GBD Region
North America, High Income
Latin America, Southern
Males
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
807.4(722.2‐905.5)
1,860.0(1,666.2‐2,091.7)
1,215.7(1,088.4‐1,364.9)
4.3(3.1‐5.6)
31.4(23.1‐40.3)
51.5(41.2‐63.2)
59.7(49.2‐72.3)
65.4(54.6‐78.2)
82.3(70.0‐96.8)
115.6(99.3‐134.4)
172.2(146.1‐201.7)
307.5(268.8‐353.7)
545.0(475.8‐636.5)
900.2(776.0‐1,058.3)
1,481.4(1,297.5‐1,711.8)
2,332.9(2,022.7‐2,691.5)
3,558.4(3,126.3‐4,065.5)
5,189.6(4,589.3‐5,935.8)
7,266.3(6,457.4‐8,230.0)
11,632.0(10,277.4‐13,077.4)
10,574.6(5,402.9‐18,632.0)
729.9(375.1‐1,319.9)
1,680.7(866.5‐3,057.9)
1,098.7(565.4‐1,990.5)
3.9(1.7‐7.8)
28.6(13.0‐57.0)
47.3(22.2‐90.6)
55.5(27.0‐104.6)
61.0(29.9‐114.3)
75.3(37.3‐136.4)
103.5(52.2‐194.0)
151.7(75.2‐283.8)
270.3(136.8‐487.7)
481.1(236.0‐890.8)
795.3(382.1‐1,504.8)
1,316.5(640.9‐2,411.0)
2,091.6(999.0‐3,861.8)
3,221.4(1,539.0‐6,016.8)
4,742.5(2,255.3‐9,019.4)
6,678.9(3,332.7‐12,253.1)
Europe, Western
539.1(468.3‐651.6)
1,235.7(1,072.9‐1,493.0)
809.4(703.2‐978.0)
3.4(2.4‐4.7)
24.5(17.8‐33.8)
41.0(32.6‐52.5)
47.3(38.3‐59.8)
50.0(40.7‐62.6)
59.4(49.0‐73.3)
79.3(65.6‐98.3)
113.9(92.7‐143.5)
201.8(168.1‐252.0)
355.7(300.8‐431.8)
584.7(490.6‐717.9)
978.5(828.6‐1,197.0)
1,556.8(1,285.0‐1,909.1)
2,428.6(2,048.8‐2,980.2)
3,641.3(3,081.3‐4,342.4)
5,014.8(4,239.2‐6,084.3)
7,216.5(6,115.6‐9,068.0)
Australasia
732.2(628.1‐899.2)
1,685.6(1,443.4‐2,066.2)
1,102.1(945.3‐1,352.6)
4.0(2.7‐5.6)
28.8(20.3‐39.4)
47.8(36.3‐62.6)
56.2(43.8‐73.4)
61.9(49.3‐79.1)
76.2(62.6‐96.4)
104.0(84.7‐132.7)
151.4(119.8‐194.6)
267.9(218.5‐332.9)
474.2(378.3‐597.2)
784.4(618.6‐995.2)
1,300.7(1,050.3‐1,627.2)
2,073.7(1,647.2‐2,662.1)
3,265.8(2,663.4‐4,124.5)
4,919.0(3,961.8‐6,292.0)
6,868.8(5,595.1‐8,694.7)
10,343.5(8,552.7‐13,005.1)
Asia Pacific, High Income
342.7(304.2‐385.1)
790.2(697.9‐888.8)
516.2(456.8‐580.0)
1.9(1.3‐2.4)
13.2(9.8‐17.2)
21.4(17.3‐26.0)
24.9(20.4‐29.8)
27.4(22.7‐32.5)
34.3(29.1‐40.2)
47.8(40.8‐55.5)
71.3(59.7‐84.4)
130.3(111.8‐150.3)
235.7(201.6‐271.8)
395.4(334.5‐462.6)
658.0(571.2‐757.2)
1,043.1(891.9‐1,209.3)
1,560.2(1,339.9‐1,798.0)
2,215.7(1,892.6‐2,580.5)
2,981.2(2,553.2‐3,464.4)
4,669.5(4,027.4‐5,393.4)
Europe, Eastern
601.8(326.4‐1,058.4)
1,373.6(741.5‐2,414.8)
901.9(488.1‐1,588.5)
4.3(1.9‐8.8)
30.4(13.6‐62.1)
50.0(24.3‐96.5)
57.9(28.5‐106.7)
62.2(31.0‐114.7)
72.8(37.0‐134.4)
93.6(47.8‐174.1)
130.2(65.9‐244.9)
227.1(118.5‐409.3)
412.0(217.0‐730.3)
684.6(350.1‐1,254.7)
1,120.0(579.0‐2,007.7)
1,765.2(894.0‐3,221.8)
2,629.2(1,388.1‐4,667.0)
3,820.0(2,012.7‐6,772.0)
5,309.1(2,826.6‐9,360.8)
8,356.9(4,635.3‐14,178.6)
Europe, Central
10,824.0(7,153.8‐15,865.8)
742.2(497.2‐1,066.7)
1,705.7(1,145.1‐2,459.5)
1,116.1(747.8‐1,606.7)
4.4(2.4‐7.2)
31.5(17.6‐50.9)
51.3(31.8‐78.0)
59.6(37.2‐92.0)
64.8(40.8‐98.8)
79.3(51.3‐117.9)
107.3(68.0‐159.6)
154.7(98.4‐240.1)
271.4(176.6‐417.8)
481.4(317.3‐704.9)
799.3(515.1‐1,196.8)
1,325.5(867.6‐1,951.0)
2,114.7(1,389.9‐3,213.5)
3,256.7(2,103.6‐4,986.2)
4,818.2(3,025.8‐7,350.0)
6,821.1(4,375.7‐10,366.7)
Asia, Central
592.8(402.6‐854.7)
1,355.1(913.7‐1,965.6)
889.0(601.6‐1,282.4)
3.9(2.0‐6.8)
28.7(15.3‐49.5)
47.9(28.7‐77.3)
55.7(34.1‐89.8)
59.9(36.4‐96.3)
69.7(43.5‐109.0)
89.2(55.5‐137.5)
124.3(78.5‐193.1)
225.7(147.3‐348.6)
423.8(276.4‐656.0)
714.1(455.8‐1,138.9)
1,150.5(755.2‐1,747.4)
1,772.7(1,145.7‐2,801.1)
2,590.1(1,699.5‐3,947.7)
3,694.0(2,444.5‐5,481.9)
5,080.6(3,357.3‐7,558.5)
8,111.0(5,258.8‐12,334.6)
Sub‐Saharan Africa, West
580.7(366.8‐941.8)
1,324.6(835.0‐2,145.5)
870.0(549.6‐1,408.7)
3.9(1.9‐7.0)
29.1(14.7‐51.6)
48.9(27.5‐83.1)
57.2(32.7‐97.2)
61.5(35.5‐103.6)
71.0(42.0‐117.9)
90.1(54.5‐145.6)
123.9(73.4‐196.3)
214.8(130.6‐345.0)
381.0(228.2‐630.2)
632.0(374.8‐1,067.9)
1,048.1(633.2‐1,713.9)
1,670.2(1,006.8‐2,695.5)
2,557.6(1,559.6‐4,175.1)
3,731.7(2,269.8‐6,125.3)
5,214.8(3,204.6‐8,605.4)
8,215.5(5,120.0‐13,959.8)
696.2(357.7‐1,257.5)
1,598.7(823.9‐2,884.7)
1,046.6(538.5‐1,890.4)
4.0(1.8‐8.0)
29.2(13.5‐58.1)
49.0(23.7‐91.7)
57.8(27.9‐109.1)
62.9(29.9‐120.7)
75.7(36.9‐142.6)
101.3(49.7‐194.7)
145.3(71.3‐283.6)
256.5(124.2‐490.9)
456.8(222.3‐882.4)
756.5(367.8‐1,472.9)
1,254.0(612.0‐2,430.7)
1,996.3(979.3‐3,845.7)
3,067.8(1,552.8‐5,740.6)
4,496.6(2,309.6‐8,030.0)
6,314.7(3,175.6‐11,188.4)
10,091.7(5,314.8‐17,961.7)
618.4(436.9‐860.4)
1,415.1(1,001.5‐1,969.9)
927.9(656.2‐1,291.3)
3.9(2.2‐6.4)
29.1(16.4‐47.0)
48.5(30.9‐72.8)
56.5(36.8‐82.3)
60.9(39.6‐89.8)
71.5(48.4‐104.3)
92.8(63.3‐133.8)
130.3(88.6‐190.8)
228.2(157.6‐324.8)
406.4(268.9‐595.6)
675.2(443.6‐1,021.1)
1,116.0(761.9‐1,625.2)
1,772.3(1,194.9‐2,546.7)
2,721.1(1,827.9‐3,873.7)
3,989.1(2,648.4‐5,794.5)
5,585.9(3,723.6‐8,044.9)
8,839.5(6,048.2‐12,706.1)
Sub‐Saharan Africa, Central
640.6(355.2‐1,110.6)
1,466.8(815.2‐2,564.8)
961.4(533.5‐1,674.1)
3.9(1.7‐7.7)
29.6(13.6‐58.4)
49.7(24.3‐94.2)
57.9(28.2‐108.4)
62.4(30.7‐115.8)
73.1(37.4‐136.0)
94.6(48.7‐175.4)
132.5(70.2‐249.0)
232.7(121.1‐433.3)
415.9(214.5‐772.1)
691.8(346.3‐1,288.2)
1,147.7(600.6‐2,090.6)
1,830.1(951.0‐3,403.7)
2,818.7(1,488.5‐5,047.6)
4,142.4(2,210.6‐7,511.7)
5,822.0(3,115.5‐10,465.5)
9,245.6(5,222.1‐16,431.7)
North Africa / Middle East
645.8(485.9‐864.6)
1,485.5(1,114.2‐1,993.7)
971.5(730.3‐1,302.5)
3.7(2.5‐5.3)
26.7(18.2‐37.9)
43.7(31.7‐60.1)
50.6(36.3‐70.6)
55.2(39.5‐76.4)
67.6(48.5‐92.6)
92.3(67.5‐123.6)
134.5(99.0‐184.5)
239.0(174.2‐323.7)
426.5(305.5‐590.6)
707.5(501.3‐978.8)
1,165.3(857.2‐1,620.3)
1,848.5(1,311.3‐2,599.7)
2,834.5(2,078.9‐3,823.8)
4,179.3(3,009.4‐5,605.3)
5,886.7(4,273.7‐7,985.6)
9,378.5(6,941.8‐12,586.9)
513.9(442.0‐613.0)
1,179.3(1,010.3‐1,411.5)
772.1(662.6‐921.5)
3.1(2.2‐4.3)
22.9(16.5‐30.6)
37.6(29.9‐47.2)
43.5(34.8‐54.0)
46.8(38.0‐57.7)
56.0(46.4‐68.2)
74.7(61.9‐90.8)
107.0(87.7‐131.6)
189.6(159.0‐224.6)
339.8(278.3‐414.3)
563.8(451.5‐702.2)
934.1(769.6‐1,135.3)
1,488.3(1,193.4‐1,825.8)
2,276.8(1,881.9‐2,792.3)
3,317.3(2,726.3‐4,115.6)
4,617.8(3,776.1‐5,754.2)
7,358.2(6,064.2‐9,185.4)
670.7(391.1‐1,122.8)
1,545.8(903.7‐2,584.2)
1,010.4(589.8‐1,690.3)
3.3(1.6‐6.3)
24.5(11.9‐46.3)
41.6(21.4‐76.8)
49.6(25.6‐93.1)
54.9(28.4‐101.6)
68.5(35.8‐123.0)
95.2(49.7‐173.3)
140.1(72.0‐260.1)
248.1(130.5‐462.4)
438.5(229.0‐831.7)
721.3(371.0‐1,369.7)
1,199.3(632.8‐2,207.2)
1,923.1(1,029.2‐3,421.2)
2,977.0(1,665.9‐5,151.1)
4,383.2(2,553.4‐7,659.0)
6,208.5(3,664.0‐10,270.7)
9,690.2(6,038.6‐15,079.2)
7,593.4(4,916.6‐11,243.2)
Sub‐Saharan Africa, Southern
Sub‐Saharan Africa, East
Asia, South
Oceania
Asia, Southeast
546.6(348.8‐821.1)
1,251.9(796.2‐1,885.3)
820.7(523.2‐1,234.6)
3.4(1.8‐5.6)
24.9(13.7‐41.2)
41.4(25.1‐65.7)
48.5(30.0‐77.7)
52.4(32.4‐83.6)
62.3(40.1‐99.5)
82.3(52.7‐130.5)
117.3(74.2‐187.9)
209.1(132.5‐330.2)
377.9(232.5‐606.5)
628.3(374.6‐1,007.2)
1,024.2(618.9‐1,619.4)
1,599.8(967.3‐2,518.1)
2,411.4(1,484.8‐3,706.9)
3,482.0(2,153.8‐5,461.2)
4,817.2(3,026.4‐7,492.8)
Asia, East
491.7(444.0‐546.1)
1,130.1(1,015.2‐1,259.8)
739.4(666.4‐822.5)
2.8(1.9‐3.8)
20.6(14.4‐26.9)
34.3(27.7‐41.7)
40.0(33.0‐48.7)
43.3(35.9‐52.1)
52.2(44.9‐61.2)
70.6(60.5‐81.4)
101.7(85.9‐120.1)
178.8(155.4‐205.1)
320.3(271.7‐380.0)
532.6(441.1‐647.4)
883.9(761.6‐1,032.9)
1,412.6(1,168.0‐1,685.0)
2,175.2(1,822.5‐2,565.1)
3,185.4(2,667.3‐3,726.2)
4,452.2(3,789.7‐5,164.9)
7,160.8(6,203.4‐8,183.0)
Latin America, Tropical
630.7(567.1‐698.6)
1,449.5(1,293.3‐1,614.1)
948.4(850.5‐1,051.4)
3.7(2.5‐5.1)
26.8(18.4‐35.9)
43.5(34.3‐53.8)
50.5(40.3‐61.9)
55.4(45.1‐67.9)
67.3(57.0‐80.2)
90.2(76.0‐107.1)
129.7(106.0‐158.5)
229.5(195.9‐267.5)
410.6(345.5‐491.2)
682.1(557.6‐833.5)
1,131.3(951.2‐1,316.4)
1,806.4(1,454.5‐2,169.0)
2,777.1(2,336.9‐3,265.6)
4,082.0(3,362.7‐4,868.0)
5,729.9(4,815.4‐6,836.5)
9,223.8(7,887.7‐10,765.9)
Latin America, Central
675.0(396.9‐1,134.6)
1,541.0(903.4‐2,584.2)
1,012.0(593.4‐1,699.1)
4.5(2.1‐8.5)
32.8(16.0‐61.6)
54.9(29.5‐98.2)
64.4(35.2‐115.7)
69.4(38.5‐121.5)
81.6(45.8‐140.2)
106.6(60.3‐182.3)
149.6(83.9‐253.7)
257.8(148.3‐436.4)
453.7(263.5‐771.6)
747.6(431.7‐1,274.4)
1,237.6(721.3‐2,112.3)
1,969.3(1,144.4‐3,372.4)
2,994.1(1,716.6‐5,083.8)
4,328.0(2,520.8‐7,127.1)
5,960.5(3,356.7‐9,897.9)
9,384.1(5,201.9‐16,709.5)
Latin America, Andean
697.0(390.7‐1,208.1)
1,598.5(893.9‐2,771.7)
1,047.0(587.0‐1,813.5)
4.2(2.0‐7.7)
31.0(15.0‐56.7)
51.3(26.0‐91.3)
59.6(30.6‐105.3)
64.5(33.1‐112.8)
77.1(41.3‐134.1)
102.6(55.6‐179.8)
146.6(80.6‐259.5)
256.9(137.5‐456.1)
455.6(238.3‐835.7)
752.8(384.8‐1,396.2)
1,245.5(664.6‐2,266.8)
1,986.3(1,063.0‐3,627.1)
3,060.6(1,673.5‐5,503.6)
4,503.3(2,486.6‐7,865.8)
6,325.7(3,559.2‐10,958.3)
10,139.4(5,539.7‐17,473.1)
Caribbean
810.3(490.3‐1,289.0)
1,864.9(1,128.6‐2,976.1)
1,219.4(738.3‐1,942.2)
4.4(2.5‐7.4)
32.4(18.2‐53.7)
53.8(31.5‐85.4)
62.9(36.9‐97.2)
68.7(39.8‐105.5)
84.1(50.2‐131.0)
114.6(71.4‐172.6)
167.5(102.1‐257.8)
297.9(181.9‐467.9)
531.5(312.4‐853.1)
876.9(511.8‐1,415.7)
1,453.6(889.9‐2,276.6)
2,325.8(1,413.4‐3,708.5)
3,607.2(2,184.1‐5,699.8)
5,323.2(3,178.1‐8,527.3)
7,456.6(4,403.8‐12,322.7)
11,587.2(6,551.9‐19,691.3)
Developed
608.2(547.0‐693.5)
1,396.2(1,254.6‐1,589.9)
914.2(822.0‐1,041.4)
3.7(2.9‐4.8)
26.7(21.2‐33.8)
43.5(36.4‐53.2)
49.7(42.2‐59.8)
53.9(46.6‐64.1)
66.4(57.6‐79.4)
90.6(78.5‐108.2)
130.5(113.4‐154.0)
227.8(201.0‐264.7)
400.7(357.0‐460.4)
660.3(562.1‐802.0)
1,093.2(955.8‐1,285.0)
1,750.6(1,506.5‐2,085.4)
2,720.0(2,416.1‐3,089.5)
4,028.0(3,621.7‐4,545.7)
5,547.2(4,964.1‐6,332.5)
8,502.1(7,655.8‐9,648.9)
Developing
546.6(503.0‐599.6)
1,253.5(1,153.0‐1,376.7)
821.0(755.1‐900.9)
3.4(2.9‐3.9)
24.8(21.1‐28.6)
41.0(36.2‐46.4)
47.0(41.8‐52.8)
50.3(45.3‐56.2)
60.4(54.8‐66.8)
80.3(73.2‐88.9)
114.0(103.7‐126.6)
202.0(184.8‐223.7)
361.9(328.0‐405.0)
599.5(536.2‐675.9)
988.6(897.1‐1,098.7)
1,573.7(1,413.5‐1,761.9)
2,408.6(2,178.2‐2,672.2)
3,505.3(3,151.6‐3,872.6)
4,916.5(4,433.7‐5,454.7)
7,891.4(7,204.4‐8,724.8)
Global
569.5(532.8‐612.7)
1,307.4(1,222.5‐1,407.3)
855.8(800.5‐920.8)
3.4(2.9‐3.9)
25.0(21.7‐28.5)
41.4(37.2‐46.2)
47.4(43.0‐52.6)
51.0(46.6‐56.2)
61.7(56.7‐67.6)
82.8(76.7‐90.2)
118.2(109.0‐129.0)
209.6(194.5‐227.9)
373.2(343.4‐405.5)
618.7(562.4‐682.2)
1,022.1(940.2‐1,113.9)
1,636.6(1,494.6‐1,792.8)
2,522.9(2,337.1‐2,731.5)
3,688.7(3,420.5‐3,991.8)
5,189.9(4,815.7‐5,634.9)
8,189.5(7,644.1‐8,910.3)
GBD Region
Females
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
North America, High Income
470.7(420.1‐522.1)
1,081.7(963.4‐1,201.6)
708.0(631.6‐786.1)
2.7(1.9‐3.5)
19.4(14.7‐24.9)
31.8(26.1‐38.0)
36.9(30.7‐43.7)
40.2(33.2‐47.8)
50.6(42.8‐59.0)
71.0(60.8‐81.9)
105.4(89.3‐121.3)
185.4(159.4‐211.1)
323.8(276.2‐375.8)
528.2(443.0‐619.8)
855.2(735.5‐985.1)
1,330.0(1,138.3‐1,524.8)
2,038.9(1,780.3‐2,309.9)
3,005.5(2,643.7‐3,399.5)
4,296.2(3,817.2‐4,850.0)
6,758.7(5,922.4‐7,665.3)
Latin America, Southern
443.7(229.3‐808.5)
1,021.3(527.9‐1,863.4)
667.7(345.0‐1,218.0)
2.4(1.1‐4.8)
17.7(8.1‐34.4)
29.3(13.6‐55.4)
34.3(16.3‐65.0)
37.5(18.5‐70.4)
45.9(23.6‐84.0)
62.6(32.2‐115.4)
91.3(46.0‐168.0)
163.9(82.1‐298.6)
293.7(147.3‐534.1)
487.8(243.9‐910.0)
813.1(408.7‐1,476.7)
1,298.6(632.6‐2,475.6)
2,004.9(997.5‐3,828.3)
2,942.8(1,426.3‐5,493.5)
4,083.1(2,031.1‐7,531.6)
6,095.4(3,081.7‐11,305.1)
Europe, Western
333.2(289.6‐395.7)
761.7(661.8‐903.3)
499.6(434.5‐593.4)
2.2(1.6‐3.0)
16.2(11.8‐21.5)
27.1(21.9‐34.0)
31.3(25.3‐39.1)
32.8(26.7‐40.5)
38.5(32.2‐47.0)
50.9(42.5‐61.9)
72.1(59.4‐88.3)
127.0(107.3‐153.6)
222.5(189.6‐266.4)
363.8(306.1‐439.1)
608.4(514.5‐738.2)
960.4(794.1‐1,160.8)
1,456.7(1,214.8‐1,756.6)
2,154.1(1,800.0‐2,596.8)
3,086.6(2,634.3‐3,707.1)
4,602.1(3,860.9‐5,592.6)
Australasia
453.8(386.2‐554.7)
1,045.2(888.6‐1,280.2)
683.1(581.1‐835.3)
2.5(1.7‐3.4)
18.0(12.8‐24.4)
29.5(23.1‐38.6)
34.4(26.8‐45.6)
37.6(29.7‐49.2)
46.4(37.6‐59.3)
63.5(50.6‐81.8)
92.4(72.7‐119.3)
165.1(135.2‐206.4)
293.5(237.7‐367.2)
487.0(389.0‐615.8)
819.7(660.3‐1,020.5)
1,322.5(1,041.3‐1,678.8)
2,085.2(1,698.4‐2,579.0)
3,104.7(2,479.4‐3,924.1)
4,258.9(3,445.8‐5,317.7)
6,098.8(4,890.5‐7,737.9)
Asia Pacific, High Income
204.9(182.2‐229.0)
472.6(419.3‐529.6)
308.6(274.1‐344.9)
1.1(0.8‐1.5)
7.9(5.8‐10.0)
12.7(10.3‐15.5)
14.8(12.2‐17.7)
16.4(13.5‐19.7)
20.3(17.0‐24.1)
27.7(23.6‐32.4)
40.8(33.9‐48.6)
76.7(66.0‐89.0)
142.6(122.3‐167.4)
242.5(207.9‐286.4)
400.9(349.5‐459.9)
628.7(536.8‐732.1)
932.9(802.6‐1,073.2)
1,315.0(1,118.7‐1,535.5)
1,773.0(1,524.3‐2,083.0)
2,772.2(2,413.4‐3,193.1)
Europe, Eastern
357.2(188.8‐625.2)
816.3(431.6‐1,430.4)
535.5(283.2‐937.2)
2.5(1.1‐5.0)
17.7(8.1‐35.0)
29.0(14.6‐55.2)
33.5(16.8‐63.4)
36.1(18.2‐69.6)
42.1(21.6‐80.1)
53.5(28.1‐102.6)
73.6(38.2‐138.7)
128.6(67.3‐236.6)
235.0(120.6‐418.2)
391.6(193.8‐712.8)
649.6(324.0‐1,151.1)
1,037.1(508.7‐1,905.4)
1,565.5(807.6‐2,838.4)
2,281.3(1,180.2‐4,101.1)
3,184.6(1,649.1‐5,650.5)
5,131.3(2,620.7‐9,215.2)
Europe, Central
427.2(288.2‐661.8)
980.8(657.7‐1,524.9)
642.0(432.0‐995.3)
2.6(1.3‐4.5)
18.7(9.7‐32.0)
30.6(18.1‐47.7)
35.7(21.9‐57.0)
38.6(24.3‐60.6)
46.4(29.8‐71.9)
61.4(39.4‐96.5)
87.2(57.3‐140.6)
153.5(102.6‐244.8)
274.8(179.0‐433.8)
459.5(289.6‐738.3)
764.8(495.1‐1,180.8)
1,222.5(773.5‐1,922.4)
1,871.9(1,197.6‐2,976.2)
2,755.8(1,766.0‐4,373.1)
3,890.9(2,558.0‐5,957.8)
6,282.7(4,156.0‐9,804.7)
Asia, Central
357.4(234.9‐538.5)
815.5(534.4‐1,240.3)
535.7(351.5‐810.5)
2.4(1.2‐4.1)
17.3(9.1‐29.0)
29.4(17.7‐45.9)
34.6(20.8‐55.5)
37.2(22.6‐59.8)
43.6(27.2‐67.6)
56.5(35.0‐87.4)
79.0(48.3‐122.9)
136.2(85.0‐210.9)
244.2(155.0‐377.9)
404.0(249.1‐629.3)
677.1(436.7‐1,033.8)
1,096.5(691.2‐1,750.8)
1,624.7(1,014.4‐2,549.3)
2,283.5(1,411.9‐3,588.7)
3,071.6(1,935.2‐4,822.1)
4,734.8(2,986.9‐7,361.8)
Sub‐Saharan Africa, West
422.3(272.8‐693.1)
969.5(620.0‐1,598.6)
634.7(408.1‐1,043.1)
2.4(1.3‐4.3)
18.1(9.8‐31.9)
30.3(17.7‐49.8)
35.4(20.9‐59.1)
38.3(22.5‐64.1)
46.0(28.0‐77.1)
61.4(37.3‐100.7)
88.2(53.9‐142.5)
155.8(98.1‐259.9)
277.2(171.7‐479.5)
458.6(280.8‐798.3)
758.8(467.1‐1,304.4)
1,208.4(738.1‐1,971.0)
1,861.7(1,145.4‐3,063.2)
2,736.7(1,669.7‐4,506.6)
3,851.2(2,356.3‐6,615.4)
6,089.2(3,649.5‐10,432.8)
Sub‐Saharan Africa, Southern
483.4(256.0‐870.1)
1,112.0(587.9‐1,996.2)
727.3(384.8‐1,306.8)
2.7(1.3‐5.3)
19.5(9.5‐38.6)
32.4(16.5‐63.7)
37.9(19.0‐75.2)
41.3(20.9‐80.3)
50.8(25.9‐95.4)
69.7(35.7‐130.3)
101.9(53.2‐190.5)
182.3(93.8‐344.3)
325.7(165.7‐617.5)
538.3(273.8‐1,012.1)
894.7(449.6‐1,672.3)
1,429.5(714.3‐2,605.8)
2,204.4(1,117.8‐4,017.4)
3,215.8(1,654.2‐5,748.9)
4,429.9(2,312.0‐8,070.9)
6,449.3(3,264.7‐11,926.0)
Sub‐Saharan Africa, East
425.8(294.9‐594.3)
977.8(673.9‐1,371.1)
640.0(442.1‐895.8)
2.5(1.4‐4.0)
18.2(10.7‐29.1)
30.5(19.9‐46.0)
35.7(23.2‐52.9)
38.6(25.2‐57.1)
46.1(31.0‐66.1)
61.2(42.1‐86.4)
87.4(58.8‐125.6)
154.8(106.0‐224.0)
276.3(185.6‐411.0)
459.7(298.2‐701.1)
765.7(511.1‐1,125.9)
1,226.1(813.5‐1,781.9)
1,891.8(1,259.9‐2,748.4)
2,777.9(1,836.1‐4,018.0)
3,892.0(2,628.5‐5,555.7)
6,100.8(4,244.4‐8,510.0)
Sub‐Saharan Africa, Central
417.0(228.2‐724.4)
957.3(523.4‐1,673.7)
626.7(342.6‐1,091.1)
2.4(1.0‐4.5)
17.7(8.0‐33.8)
29.8(14.5‐54.3)
34.9(17.0‐65.3)
37.9(18.4‐69.7)
45.5(23.2‐80.5)
60.4(31.8‐107.9)
86.4(44.6‐155.7)
152.3(79.8‐275.9)
270.9(142.0‐500.4)
448.7(232.5‐827.0)
744.1(385.5‐1,338.3)
1,188.0(623.5‐2,118.5)
1,838.0(992.3‐3,263.8)
2,713.1(1,449.1‐4,761.4)
3,822.9(2,047.2‐6,628.7)
6,042.0(3,326.8‐10,490.9)
North Africa / Middle East
405.0(291.4‐553.6)
932.0(668.2‐1,276.3)
609.4(438.7‐834.4)
2.3(1.5‐3.4)
16.4(10.8‐24.0)
27.0(19.2‐38.5)
31.4(22.1‐44.0)
34.3(24.1‐48.2)
42.0(30.0‐58.9)
57.2(40.7‐80.2)
83.4(59.0‐117.1)
148.9(106.3‐210.9)
266.3(192.0‐374.2)
441.4(313.2‐629.6)
730.2(520.4‐1,011.8)
1,159.8(813.0‐1,627.8)
1,793.2(1,273.9‐2,464.9)
2,654.0(1,808.1‐3,681.3)
3,744.8(2,621.7‐5,305.1)
5,783.6(4,168.0‐7,972.9)
Asia, South
327.5(282.3‐382.7)
752.1(645.9‐881.0)
492.3(423.9‐575.6)
2.0(1.3‐2.6)
14.2(10.0‐19.0)
23.3(18.2‐29.2)
27.1(21.4‐34.2)
29.4(23.5‐36.7)
35.5(29.2‐43.7)
47.6(39.4‐57.6)
68.4(55.6‐83.2)
121.2(100.8‐146.9)
216.8(178.3‐264.6)
358.6(289.4‐440.2)
592.6(496.3‐712.2)
943.6(761.7‐1,155.6)
1,449.0(1,180.5‐1,767.7)
2,119.9(1,695.4‐2,604.2)
2,958.0(2,420.9‐3,598.5)
4,704.3(3,935.7‐5,669.9)
Oceania
406.2(213.2‐747.4)
935.3(488.8‐1,733.3)
611.4(320.2‐1,128.6)
2.2(1.0‐4.4)
15.9(7.5‐32.1)
26.6(13.5‐50.2)
31.3(15.6‐59.0)
34.2(17.2‐63.6)
41.8(21.5‐76.1)
57.1(28.8‐104.6)
83.3(41.9‐155.7)
148.5(76.8‐274.7)
265.5(136.2‐498.2)
440.2(224.6‐832.2)
729.0(372.5‐1,396.0)
1,162.9(577.7‐2,205.6)
1,799.2(899.8‐3,391.4)
2,655.5(1,337.7‐4,989.6)
3,737.1(1,935.7‐6,869.1)
5,872.0(3,154.2‐10,486.5)
Asia, Southeast
329.6(208.8‐520.9)
755.4(477.1‐1,194.5)
495.0(313.7‐783.3)
2.1(1.1‐3.5)
14.9(8.2‐25.2)
24.8(14.5‐39.7)
28.9(17.4‐46.7)
31.2(18.9‐50.4)
37.1(22.9‐58.4)
48.9(30.9‐78.0)
69.7(44.4‐110.3)
124.0(78.4‐191.8)
223.8(138.1‐362.4)
372.0(228.4‐607.8)
606.0(371.6‐976.0)
947.1(572.6‐1,531.0)
1,439.0(897.1‐2,328.4)
2,098.7(1,292.7‐3,381.6)
2,931.4(1,820.5‐4,726.2)
4,728.7(2,969.9‐7,387.8)
Asia, East
338.6(304.7‐371.9)
779.8(699.3‐859.9)
509.7(458.1‐560.0)
1.9(1.3‐2.4)
13.3(9.7‐17.2)
22.1(18.1‐26.6)
25.7(20.9‐31.0)
28.1(23.3‐33.5)
34.7(29.6‐40.6)
48.2(40.9‐56.2)
70.7(59.3‐83.8)
124.6(107.9‐143.8)
221.7(187.7‐258.1)
367.0(305.3‐437.2)
608.6(520.7‐705.1)
972.7(808.5‐1,165.1)
1,505.3(1,278.7‐1,775.6)
2,212.6(1,854.9‐2,618.5)
3,108.2(2,652.4‐3,594.4)
4,874.8(4,195.1‐5,651.8)
Latin America, Tropical
397.7(356.1‐447.7)
915.0(818.7‐1,034.7)
598.3(536.1‐674.9)
2.3(1.6‐3.1)
16.4(11.7‐21.7)
26.8(21.3‐32.8)
31.2(25.3‐38.2)
34.1(27.9‐42.2)
41.5(34.8‐49.4)
56.1(47.2‐65.8)
81.2(67.4‐96.8)
144.5(123.8‐167.6)
259.1(215.8‐304.1)
430.1(350.0‐516.4)
713.0(604.7‐840.4)
1,137.9(928.2‐1,373.2)
1,758.0(1,476.7‐2,082.0)
2,596.6(2,148.1‐3,121.6)
3,656.6(3,081.3‐4,292.9)
5,758.5(4,950.7‐6,663.4)
Latin America, Central
415.2(249.6‐678.3)
950.8(568.5‐1,549.9)
623.3(372.9‐1,017.4)
2.6(1.3‐4.6)
18.8(9.8‐33.0)
31.7(18.3‐52.3)
37.2(21.7‐61.8)
39.9(23.3‐65.1)
47.2(28.2‐75.3)
62.3(37.5‐101.2)
88.8(52.5‐146.6)
157.3(96.0‐257.2)
282.6(167.1‐450.8)
471.0(273.3‐764.9)
781.4(447.8‐1,276.9)
1,237.7(717.0‐2,049.2)
1,854.5(1,087.7‐3,075.8)
2,639.1(1,526.3‐4,302.3)
3,616.8(2,065.1‐5,991.6)
5,753.2(3,233.8‐9,641.4)
Latin America, Andean
445.8(238.3‐763.5)
1,023.6(547.3‐1,760.0)
670.0(357.9‐1,149.0)
2.6(1.2‐5.1)
19.2(9.2‐36.3)
31.8(16.6‐57.9)
37.1(19.1‐66.8)
40.2(20.7‐71.9)
48.2(24.9‐84.8)
63.9(34.1‐112.1)
91.3(47.9‐161.2)
161.6(86.8‐281.5)
289.3(149.4‐508.1)
480.8(238.8‐852.7)
799.8(409.8‐1,408.1)
1,279.2(665.3‐2,353.3)
1,969.9(1,018.6‐3,553.4)
2,891.9(1,502.7‐5,041.4)
4,061.7(2,142.6‐7,016.0)
6,465.2(3,430.4‐11,012.2)
Caribbean
488.6(304.9‐780.7)
1,123.1(697.2‐1,807.1)
734.9(458.4‐1,178.7)
2.7(1.5‐4.4)
19.8(11.4‐31.8)
33.4(20.3‐50.7)
39.3(24.1‐60.7)
42.8(25.9‐66.3)
52.0(32.0‐80.8)
70.5(43.4‐108.5)
102.3(61.0‐160.6)
183.0(112.0‐281.2)
328.1(201.5‐522.8)
542.5(328.2‐868.4)
902.7(557.7‐1,407.9)
1,444.5(868.8‐2,332.7)
2,233.3(1,358.5‐3,617.1)
3,264.6(1,923.1‐5,336.6)
4,501.8(2,656.8‐7,367.9)
6,465.0(3,708.2‐10,925.7)
Developed
362.5(319.3‐422.3)
830.9(730.9‐968.9)
544.5(479.4‐634.2)
2.3(1.9‐2.9)
16.5(13.4‐20.7)
26.8(22.7‐32.6)
30.7(26.4‐36.7)
33.3(28.9‐39.4)
40.7(35.3‐48.2)
55.0(47.6‐65.4)
78.4(67.8‐92.4)
136.8(120.0‐159.3)
240.7(211.7‐275.7)
394.1(333.1‐476.9)
652.5(565.5‐778.2)
1,039.1(882.3‐1,271.1)
1,590.0(1,389.5‐1,874.1)
2,344.1(2,057.9‐2,725.9)
3,306.3(2,875.5‐3,870.3)
5,167.5(4,565.1‐5,998.8)
Developing
358.2(329.8‐393.0)
822.8(756.8‐902.2)
538.4(495.8‐590.4)
2.1(1.8‐2.5)
15.4(13.2‐17.8)
25.5(22.7‐28.6)
29.3(26.0‐32.8)
31.6(28.2‐35.3)
38.4(34.6‐42.6)
51.9(47.1‐57.6)
74.7(67.6‐82.8)
132.6(120.5‐145.9)
237.2(213.8‐264.1)
392.1(350.4‐439.7)
648.1(586.7‐719.0)
1,033.9(928.6‐1,158.3)
1,589.3(1,437.0‐1,780.6)
2,324.9(2,104.5‐2,590.9)
3,254.8(2,950.5‐3,607.8)
5,107.9(4,656.3‐5,610.2)
Global
359.9(334.7‐392.6)
826.5(768.4‐902.3)
541.0(502.9‐590.5)
2.1(1.9‐2.5)
15.5(13.6‐17.6)
25.7(23.2‐28.5)
29.5(26.8‐32.6)
31.9(28.9‐35.1)
38.9(35.5‐42.6)
52.7(48.2‐57.7)
75.7(69.4‐83.0)
133.9(123.6‐145.4)
238.2(220.0‐259.5)
392.8(359.0‐432.1)
649.6(599.3‐708.2)
1,036.0(943.3‐1,147.3)
1,589.6(1,455.7‐1,745.4)
2,333.1(2,146.6‐2,559.8)
3,281.8(3,018.2‐3,635.3)
5,143.5(4,746.3‐5,689.2)
Supplemental Table 2. Median Percentage Change in Prevalence and DALYs related to Atrial Fibrillation for all GBD Regions
DALYs (per 100,000)
Prevalence (per 100,000)
Region
1990
2010
Median % change,
1990 to 2010
1990
2010
Median %
change, 1990 to
2010
Global
45.6
(34.0 - 59.7)
54.5
(41.9 - 69.9)
19.9
(10.7 to 29.6)
452.0
(430.4 - 477.9)
474.0
(452.6 - 496.3)
5.0
(-2.7 to 12.0)
Asia Pacific, High
Income
36.0
(28.7 - 45.7)
39.6
(29.6 - 53.0)
8.6
(-9.5 to 38.1)
263.6
(243.5 - 286.1)
260.9
(241.2 - 285.0)
-1.0
(-11.7 to 11.3)
Asia, Central
37.0
(23.7 - 56.1)
41.1
(27.1 - 61.2)
10.4
(-22.2 to 62.2)
448.4
(333.0 - 608.6)
484.8
(362.5 - 640.2)
7.9
(-26.3 to 62.8)
Asia, East
40.1
(27.7 - 55.4)
42.7
(30.4 - 57.9)
6.6
(-12.2 to 29.6)
409.4
(381.9 - 440.1)
395.1
(370.3 - 421.1)
-3.5
(-12.1 to 5.5)
Asia, South
37.8
(25.4 - 52.3)
43.3
(29.4 - 61.5)
13.9
(-4.7 to 38.9)
423.0
(378.6 - 481.5)
447.7
(403.5 - 502.9)
5.9
(-10.1 to 23.5)
Asia, Southeast
35.6
(22.3 - 54.5)
40.6
(26.3 - 60.9)
13.9
(-22.6 to 67.9)
428.0
(302.7 - 592.6)
456.3
(331.4 - 612.3)
6.8
(-31.2 to 63.7)
Australasia
61.6
(46.0 - 81.3)
74.0
(55.8 - 96.0)
19.8
(-1.1 to 49.2)
575.9
(509.4 - 672.1)
580.8
(514.4 - 667.7)
1.0
(-17.4 to 21.7)
Caribbean
62.1
(41.6 - 93.4)
71.0
(49.4 - 101.8)
15.2
(-21.4 to 63.9)
640.8
(448.8 - 889.2)
661.9
(468.2 - 950.7)
3.7
(-36.3 to 65.9)
Europe, Central
54.4
(37.7 - 77.0)
65.1
(47.2 - 91.7)
20.2
(-11.8 to 60.0)
558.4
(429.5 - 730.1)
602.2
(453.9 - 802.7)
7.9
(-26.5 to 56.9)
Europe, Eastern
37.4
(21.8 - 60.0)
45.0
(26.7 - 72.0)
19.5
(-29.7 to 108.7)
440.5
(277.6 - 658.7)
496.4
(310.7 - 746.0)
11.3
(-37.9 to 112.2)
Europe, Western
52.0
(40.9 - 65.7)
71.0
(57.0 - 87.4)
36.9
(20.1 to 54.9)
419.4
(378.0 - 475.1)
464.9
(420.0 - 526.3)
11.1
(-6.8 to 30.0)
Latin America,
Andean
50.9
(31.0 - 78.1)
55.3
(34.6 - 89.1)
9.0
(-34.6 to 76.2)
561.5
(376.8 - 831.4)
594.0
(385.2 - 909.8)
6.7
(-41.7 to 89.6)
Latin America,
Central
48.1
(30.8 - 74.5)
54.0
(35.4 - 80.2)
11.6
(-28.2 to 73.3)
533.2
(361.9 - 781.0)
546.4
(372.5 - 797.5)
2.0
(-41.0 to 71.9)
Latin America,
Southern
57.9
(36.7 - 88.5)
67.9
(45.0 - 107.2)
16.6
(-28.2 to 92.4)
565.4
(345.9 - 872.3)
604.6
(372.0 - 980.5)
7.4
(-44.9 to 107.4)
Latin America,
Tropical
51.5
(39.2 - 67.3)
66.5
(50.4 - 86.1)
28.7
(11.9 to 51.7)
504.4
(467.7 - 542.3)
546.8
(508.8 - 589.8)
8.4
(-2.6 to 20.8)
North Africa /
Middle East
60.8
(42.5 - 84.3)
67.1
(50.4 - 88.9)
10.9
(-12.9 to 42.4)
520.9
(422.9 - 643.4)
537.1
(430.6 - 665.4)
2.6
(-24.5 to 42.2)
North America,
High Income
57.8
(41.8 - 77.9)
81.2
(59.5 - 106.4)
40.1
(20.5 to 69.5)
612.7
(567.8 - 662.5)
702.2
(645.2 - 759.7)
15.0
(1.6 to 28.3)
Oceania
50.1
(31.5 - 77.6)
87.3
(55.9 - 127.7)
76.1
(6.3 to 183.4)
528.0
(345.8 - 797.9)
502.3
(326.3 - 772.8)
-4.4
(-48.1 to 75.1)
Sub-Saharan
Africa, Central
44.4
(25.5 - 72.6)
48.7
(29.2 - 78.3)
10.3
(-36.4 to 84.2)
513.8
(334.7 - 794.1)
547.8
(345.2 - 853.5)
5.9
(-43.0 to 95.9)
Sub-Saharan
Africa, East
45.0
(29.3 - 64.9)
46.2
(31.2 - 65.4)
3.4
(-24.2 to 40.0)
513.9
(396.6 - 653.3)
518.8
(406.0 - 660.7)
1.8
(-28.4 to 45.0)
Sub-Saharan
Africa, Southern
60.8
(39.6 - 91.2)
72.3
(48.4 - 107.2)
19.5
(-27.5 to 95.7)
570.2
(353.0 - 862.7)
618.1
(382.4 - 990.5)
8.7
(-42.7 to 109.4)
Sub-Saharan
Africa, West
43.4
(26.6 - 69.3)
48.7
(31.8 - 74.4)
13.7
(-26.5 to 71.6)
495.7
(351.0 - 717.2)
533.8
(381.5 - 761.2)
8.8
(-32.8 to 74.2)
Supplemental Table 3a. Estimated age-standardized incidence rates of Atrial Fibrillation with 95% Uncertainty Intervals (per 100,000
person years) for all 21 GBD regions for males and females: 2010
GBD Region
North America, High Income
Males
35+ years
20+ years
<5 years
264.5(221.1‐311.3) 621.9(519.7‐732.9) 400.9(335.1‐472.1) 7.1(5.2‐9.5)
3.4(1.4‐7.0)
10‐14 years
12.8(10.1‐16.1)
4.3(1.6‐7.7)
6.2(2.7‐12.2)
2.2(0.5‐5.9)
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
2.6(1.3‐4.7)
5.1(3.3‐7.9)
13.7(10.2‐18.0)
22.3(16.0‐29.7)
1.4(0.4‐3.6)
2.3(0.8‐5.6)
5.9(2.5‐12.0)
9.5(4.0‐19.6)
20.8(9.5‐39.2)
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
46.6(37.4‐56.9) 94.2(74.8‐114.9) 141.1(108.4‐174.0) 237.5(190.5‐286.5) 409.2(314.3‐514.7) 688.2(557.6‐851.0) 1,138.4(880.0‐1,440.6) 1,766.1(1,420.5‐2,151.3) 2,675.3(2,070.1‐3,328.5) 4,570.2(3,716.5‐5,494.3)
Latin America, Southern
92.0(40.9‐176.6)
214.9(95.4‐414.2)
Europe, Western
102.9(78.9‐134.6)
242.0(185.6‐316.5) 155.8(119.5‐203.8) 3.2(2.1‐4.6)
5.8(4.2‐7.8)
2.1(0.7‐4.0)
1.1(0.5‐2.0)
1.7(1.1‐2.9)
4.7(3.3‐6.7)
7.7(5.2‐11.1)
17.4(12.6‐23.8)
Australasia
117.8(44.3‐254.7)
276.6(103.5‐599.0)
178.3(66.9‐385.9)
3.7(1.4‐8.0)
6.6(2.5‐14.9)
2.3(0.4‐6.5)
1.4(0.4‐3.8)
2.4(0.9‐5.7)
6.1(2.2‐13.7)
9.8(3.4‐22.8)
21.7(8.0‐48.2)
Asia Pacific, High Income
33.8(12.7‐76.8)
78.4(29.5‐178.3)
50.8(19.1‐115.8)
1.6(0.6‐3.7)
2.8(1.1‐6.5)
1.0(0.2‐2.5)
0.6(0.2‐1.5)
1.0(0.4‐2.5)
2.5(1.0‐5.9)
4.1(1.6‐9.7)
9.6(3.9‐22.1)
Europe, Eastern
57.1(26.2‐115.9)
132.0(60.0‐267.3)
85.6(39.1‐173.0)
3.6(1.4‐7.8)
6.7(2.9‐13.9)
2.3(0.4‐6.3)
1.1(0.3‐3.0)
1.6(0.6‐3.9)
4.2(1.7‐9.0)
6.9(2.7‐14.8)
15.8(6.9‐32.9)
Europe, Central
90.2(56.1‐143.2)
210.0(130.8‐333.2)
135.9(84.5‐215.7)
4.1(2.0‐7.3)
7.4(4.2‐12.6)
2.7(0.7‐6.1)
1.5(0.5‐3.4)
2.4(1.1‐4.9)
6.1(3.3‐11.5)
9.7(5.1‐18.2)
21.6(12.7‐36.3)
Asia, Central
55.0(33.7‐85.4)
126.6(77.5‐198.5)
82.1(50.4‐128.3)
3.6(1.7‐6.7)
6.8(3.7‐11.4)
2.6(0.5‐6.5)
1.2(0.3‐2.8)
1.5(0.7‐2.9)
4.2(2.1‐7.8)
7.1(3.4‐13.2)
17.4(10.2‐28.9)
Sub‐Saharan Africa, West
57.0(33.7‐93.7)
132.0(78.1‐217.0)
85.5(50.6‐140.4)
3.3(1.6‐6.1)
6.2(3.4‐10.7)
2.2(0.4‐5.7)
1.2(0.3‐2.9)
1.5(0.6‐3.3)
4.0(2.1‐7.3)
6.4(3.2‐12.1)
14.5(8.4‐24.5)
Sub‐Saharan Africa, Southern
76.9(31.4‐164.1)
178.7(72.8‐380.5)
115.7(47.0‐246.3)
3.6(1.4‐8.0)
6.7(2.6‐14.1)
2.4(0.5‐7.2)
1.3(0.4‐3.6)
2.0(0.7‐4.8)
5.3(1.9‐11.8)
8.7(3.1‐20.1)
Sub‐Saharan Africa, East
55.0(36.4‐82.0)
127.1(83.9‐189.8)
82.3(54.5‐122.9)
3.4(1.8‐5.4)
6.3(3.9‐9.5)
2.3(0.6‐5.4)
1.1(0.3‐2.4)
1.4(0.7‐2.8)
3.8(2.1‐6.4)
6.3(3.4‐10.8)
Sub‐Saharan Africa, Central
60.1(30.5‐113.4)
139.3(70.3‐263.8)
90.1(45.7‐170.0)
3.3(1.3‐7.0)
6.3(2.8‐12.7)
2.2(0.4‐6.4)
1.2(0.3‐3.2)
1.5(0.5‐3.5)
4.0(1.7‐7.9)
North Africa / Middle East
73.4(50.1‐109.9)
171.1(116.4‐255.8)
110.7(75.5‐165.6)
3.2(2.0‐4.8)
5.7(3.9‐8.6)
1.9(0.5‐3.9)
1.1(0.4‐2.3)
1.8(1.0‐3.4)
Asia, South
51.5(22.6‐110.5)
119.4(52.3‐256.7)
77.3(33.9‐165.9)
2.7(1.1‐6.2)
5.0(2.1‐11.0)
1.8(0.4‐4.7)
1.0(0.3‐2.3)
1.4(0.5‐3.1)
229.5(120.5‐429.1) 542.1(285.5‐1,013.7) 348.7(183.4‐651.7) 4.0(1.7‐8.3)
Oceania
138.9(61.7‐267.4)
5‐9 years
44.1(19.8‐86.9)
67.5(29.5‐134.5)
108.5(49.6‐214.4) 176.7(73.6‐361.9)
269.5(113.5‐532.8)
401.1(156.4‐842.4)
577.1(240.5‐1,186.4)
821.4(347.9‐1,627.9)
1,296.4(599.6‐2,443.1)
37.9(27.4‐50.9)
58.5(41.6‐79.6)
103.2(76.3‐135.1) 185.7(128.2‐254.5) 294.4(216.5‐391.0)
462.2(329.5‐634.5)
45.6(16.1‐99.2)
69.6(24.8‐151.8)
114.9(42.4‐251.5) 193.6(69.2‐450.9)
301.5(112.2‐700.0)
455.7(158.4‐1,052.5)
710.9(522.0‐935.7)
1,023.8(733.3‐1,421.2)
1,528.7(1,125.6‐2,102.4)
712.8(258.7‐1,601.9)
1,135.9(402.6‐2,573.5)
20.7(8.2‐45.7)
31.7(12.7‐69.9)
52.7(21.5‐118.3)
91.3(34.6‐213.5)
124.9(46.3‐294.2)
146.9(51.6‐366.4)
175.1(60.6‐433.2)
214.9(74.8‐533.4)
2,183.3(792.0‐4,709.8)
360.5(124.8‐851.5)
34.4(14.4‐75.7)
52.9(21.4‐118.5)
82.3(34.3‐174.2)
128.6(49.6‐276.8)
185.4(77.9‐394.7)
261.8(111.0‐579.8)
344.8(147.0‐750.7)
436.4(189.3‐906.6)
596.3(253.4‐1,195.1)
45.9(26.3‐73.9)
73.2(40.3‐117.8)
117.3(69.8‐191.6) 188.6(100.7‐333.4) 283.6(161.5‐489.4)
411.8(222.6‐704.5)
559.1(327.7‐924.5)
756.0(428.1‐1,259.3)
1,102.6(631.3‐1,768.4)
39.7(22.0‐66.6)
62.0(33.2‐106.4)
90.0(51.3‐145.8)
128.2(65.9‐225.2)
176.0(95.6‐305.7)
239.7(124.4‐424.9)
312.6(167.9‐536.2)
389.7(217.7‐675.4)
517.2(293.0‐860.6)
31.8(17.6‐54.9)
49.1(25.7‐86.9)
78.0(43.9‐130.1)
125.9(66.0‐220.0)
185.6(98.9‐326.6)
263.9(132.7‐482.1)
351.8(184.0‐626.1)
456.7(240.4‐787.7)
617.0(336.7‐1,063.4)
19.4(7.4‐41.9)
41.8(16.2‐94.1)
64.4(24.1‐146.5)
103.5(38.9‐228.2) 168.0(58.4‐386.1)
250.1(91.6‐566.6)
356.6(125.9‐811.9)
475.8(187.9‐1,082.3)
623.4(257.8‐1,359.5)
864.2(363.0‐1,813.6)
14.3(9.2‐21.7)
31.2(18.9‐48.6)
48.2(28.1‐77.4)
76.8(49.2‐121.7)
124.0(65.7‐211.4)
181.4(103.4‐294.3)
256.2(141.3‐435.1)
337.7(196.1‐560.2)
430.4(253.0‐712.1)
574.1(341.2‐910.4)
6.5(2.6‐13.4)
14.9(6.9‐28.5)
32.8(14.7‐65.4)
50.8(22.4‐102.6)
81.7(38.6‐163.4)
133.6(57.0‐277.0)
196.6(90.7‐393.2)
279.8(122.7‐539.1)
372.5(170.7‐714.6)
483.3(226.3‐976.1)
653.4(313.8‐1,304.6)
4.8(3.0‐7.2)
7.8(4.7‐11.9)
17.2(11.7‐24.7)
36.4(24.3‐53.9)
55.2(34.9‐84.8)
88.2(58.6‐132.7)
143.2(85.0‐232.3)
218.8(138.4‐348.3)
328.2(202.6‐508.7)
461.4(284.0‐714.5)
643.1(394.7‐1,020.9)
986.3(620.6‐1,546.1)
3.6(1.5‐8.0)
5.9(2.4‐13.3)
13.4(5.9‐29.1)
29.2(12.4‐63.2)
45.0(18.7‐99.2)
71.4(29.7‐155.5)
114.7(43.3‐273.0)
167.8(69.1‐375.4)
237.4(95.7‐521.8)
313.5(131.4‐707.2)
401.8(165.4‐921.6)
567.5(234.9‐1,223.9)
7.6(3.6‐15.4)
3.4(0.8‐8.6)
2.1(0.6‐5.6)
3.7(1.5‐8.9)
9.7(4.3‐21.2)
15.6(6.6‐34.1)
34.2(16.8‐71.2) 73.4(35.5‐153.8) 113.3(54.3‐231.7) 190.0(96.2‐370.5) 325.8(150.1‐671.5) 538.5(256.1‐1,053.0) 881.0(397.6‐1,797.0)
Asia, Southeast
48.9(29.4‐79.2)
112.7(67.4‐183.2)
73.2(44.0‐118.9)
3.1(1.6‐5.4)
5.6(3.2‐9.5)
1.9(0.4‐4.4)
1.0(0.3‐2.2)
1.5(0.7‐3.0)
4.0(1.9‐7.0)
6.6(3.1‐11.8)
14.4(8.1‐24.3)
30.3(17.2‐50.3)
46.2(25.9‐78.2)
71.6(41.6‐115.8)
112.4(58.8‐198.7)
162.1(88.6‐272.5)
225.6(118.6‐389.7)
1,469.6(711.8‐2,879.0)
291.1(158.5‐511.0)
2,514.1(1,223.2‐4,880.1) 4,522.6(2,447.4‐8,484.6)
362.0(195.4‐651.8)
488.7(276.5‐840.9)
Asia, East
44.5(15.6‐106.2)
102.9(36.0‐245.7)
66.8(23.4‐159.6)
2.5(0.9‐6.1)
4.5(1.6‐10.6)
1.5(0.2‐4.3)
0.8(0.2‐2.3)
1.2(0.3‐3.4)
3.4(1.1‐8.6)
5.7(1.8‐13.9)
12.4(4.3‐28.4)
25.5(8.7‐57.6)
38.7(13.3‐89.0)
60.4(21.0‐135.4)
94.4(29.7‐221.5)
141.0(47.3‐333.1)
210.3(70.4‐533.6)
278.8(92.3‐696.4)
345.9(116.3‐847.1)
488.2(164.5‐1,151.5)
Latin America, Tropical
78.7(24.0‐181.2)
183.7(55.9‐423.0)
118.7(36.2‐273.4)
3.3(1.0‐7.8)
5.9(1.9‐13.9)
2.2(0.4‐6.3)
1.2(0.3‐3.6)
1.9(0.5‐5.0)
4.8(1.5‐11.8)
7.8(2.3‐19.8)
17.5(5.4‐41.9)
37.5(11.3‐91.6)
57.5(17.3‐142.5)
92.6(27.3‐216.4)
152.3(42.2‐379.3)
232.4(66.7‐559.3)
346.8(100.1‐820.2)
496.9(143.6‐1,181.7)
706.6(211.4‐1,661.8)
1,087.2(326.7‐2,636.7)
Latin America, Central
61.5(32.0‐113.2)
142.5(73.9‐262.8)
92.3(48.0‐170.3)
3.5(1.6‐6.8)
6.4(3.1‐11.8)
2.3(0.4‐6.0)
1.2(0.3‐2.7)
1.6(0.7‐3.6)
4.3(2.0‐8.9)
7.1(3.2‐14.8)
16.2(7.9‐31.7)
34.9(16.9‐68.2)
53.6(24.8‐105.1)
84.7(42.0‐164.8)
135.2(59.8‐266.6)
199.6(95.0‐381.0)
289.1(127.3‐570.2)
382.6(179.8‐745.9)
484.7(220.2‐973.5)
657.3(314.3‐1,240.7)
Latin America, Andean
65.7(33.1‐123.2)
152.5(76.8‐286.0)
98.7(49.8‐184.7)
3.6(1.6‐7.2)
6.5(3.1‐12.4)
2.3(0.4‐6.1)
1.2(0.3‐3.2)
1.7(0.6‐4.0)
4.5(1.9‐9.7)
7.3(3.0‐15.8)
16.6(7.8‐32.1)
35.9(16.7‐72.1)
55.3(25.2‐110.8)
88.2(43.3‐167.8)
142.6(61.7‐294.6)
210.8(93.6‐402.5)
302.0(128.3‐609.5)
406.5(178.6‐811.7)
534.0(240.4‐1,099.9)
745.4(337.4‐1,479.7)
Caribbean
103.7(60.6‐178.0)
241.9(141.7‐415.2)
156.4(91.5‐268.4)
4.2(2.2‐8.0)
7.6(4.1‐13.7)
2.8(0.7‐6.6)
1.6(0.6‐3.5)
2.5(1.2‐5.0)
6.7(3.6‐11.4)
10.7(5.6‐18.6)
23.6(13.6‐38.6)
49.9(28.1‐87.6)
76.3(41.4‐136.1)
123.8(70.7‐207.0) 204.5(106.7‐357.7) 310.7(170.3‐523.4)
459.7(234.7‐835.9)
654.0(350.8‐1,144.3)
927.0(482.4‐1,742.3)
1,394.0(769.6‐2,574.9)
Developed
123.4(107.6‐141.5) 289.1(252.3‐331.0) 186.6(162.6‐213.9) 4.4(3.5‐5.5)
130.9(111.6‐152.9) 222.7(183.7‐268.6) 351.7(298.9‐414.0)
7.9(6.7‐9.6)
2.7(1.6‐4.1)
1.5(1.0‐2.3)
2.6(2.0‐3.5)
6.9(5.6‐8.5)
11.0(8.9‐13.5)
23.7(20.1‐27.9)
50.1(42.4‐59.2)
77.5(64.7‐92.5)
544.5(451.0‐645.3)
780.2(660.3‐908.0)
1,148.4(964.3‐1,365.8)
1,922.5(1,645.7‐2,252.5)
Developing
53.8(38.7‐79.8)
124.7(89.4‐185.1)
80.8(57.9‐120.1)
3.0(2.3‐4.1)
5.5(4.2‐7.3)
1.9(1.2‐3.0)
1.0(0.7‐1.6)
1.5(1.0‐2.2)
3.9(2.9‐5.6)
6.4(4.6‐9.4)
14.2(10.3‐20.6)
30.0(21.3‐44.3)
46.1(32.8‐67.1)
72.5(51.3‐105.2)
170.0(118.5‐255.8)
247.6(169.5‐378.9)
331.6(232.1‐498.9)
429.2(303.0‐645.7)
618.0(437.4‐900.0)
Global
77.5(65.2‐95.4)
181.2(152.6‐222.8)
116.9(98.4‐143.9)
3.2(2.5‐4.1)
5.8(4.6‐7.4)
2.0(1.3‐3.0)
1.1(0.8‐1.6)
1.6(1.2‐2.3)
4.4(3.5‐5.9)
7.2(5.7‐9.7)
16.0(12.7‐21.2)
34.0(26.9‐44.6)
53.3(42.2‐69.4)
87.2(69.9‐112.2) 143.1(113.7‐188.5) 225.0(184.0‐288.0)
341.7(276.0‐431.5)
487.5(404.2‐601.2)
697.9(585.0‐840.2)
1,152.2(983.4‐1,347.5)
Females
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
65‐69 years
70‐74 years
75‐79 years
80+ years
GBD Region
North America, High Income
196.3(164.9‐232.3) 462.8(387.8‐547.6) 297.9(250.2‐352.2) 4.5(3.3‐6.0)
50‐54 years
114.4(77.5‐172.9)
55‐59 years
60‐64 years
8.2(6.5‐10.3)
3.0(1.3‐5.2)
1.7(0.8‐2.9)
3.2(2.2‐4.9)
9.0(6.7‐11.6)
14.7(10.5‐19.3)
30.7(24.3‐37.5)
62.0(49.4‐76.5)
92.8(71.3‐117.5) 155.8(125.3‐188.9) 267.4(199.8‐341.0) 455.2(367.9‐557.0)
763.8(574.6‐979.3)
Latin America, Southern
60.4(27.3‐121.1)
141.3(64.2‐282.9)
2.1(0.9‐4.4)
3.8(1.6‐7.7)
1.4(0.3‐3.9)
0.8(0.2‐2.1)
1.3(0.5‐3.1)
3.6(1.5‐7.6)
5.7(2.3‐12.7)
12.9(5.6‐25.5)
27.9(12.0‐57.3)
42.9(18.4‐89.3)
256.9(104.6‐553.8)
Europe, Western
91.5(68.6‐120.6)
216.1(162.0‐284.7) 138.8(104.1‐183.0) 2.1(1.4‐3.2)
4.0(2.8‐5.5)
1.5(0.5‐2.7)
0.8(0.3‐1.3)
1.2(0.8‐2.1)
3.4(2.3‐4.8)
5.6(3.7‐8.0)
12.4(9.0‐16.7)
26.8(19.3‐36.4)
Australasia
91.4(36.9‐196.6)
215.5(87.0‐462.5)
138.7(55.9‐298.0)
2.3(0.8‐5.1)
4.1(1.6‐9.0)
1.5(0.3‐3.9)
0.9(0.2‐2.3)
1.5(0.5‐3.6)
4.0(1.5‐9.3)
6.5(2.4‐15.0)
14.5(5.6‐34.0)
30.6(12.0‐71.9)
Asia Pacific, High Income
19.8(8.3‐47.2)
46.0(19.2‐110.2)
29.8(12.4‐71.2)
1.0(0.4‐2.1)
1.7(0.7‐3.6)
0.6(0.1‐1.4)
0.4(0.1‐0.9)
0.6(0.2‐1.3)
1.4(0.6‐3.0)
2.2(0.9‐4.9)
5.3(2.3‐11.4)
11.8(5.1‐24.9)
Europe, Eastern
34.1(16.0‐71.8)
79.0(37.0‐166.3)
51.1(23.9‐107.7)
2.0(0.8‐4.4)
3.6(1.6‐7.9)
1.2(0.2‐3.0)
0.6(0.2‐1.6)
0.9(0.3‐2.2)
2.3(0.9‐5.2)
3.8(1.4‐8.3)
8.8(3.8‐19.0)
19.6(8.4‐42.1)
Europe, Central
54.5(32.9‐90.8)
126.9(76.3‐211.2)
82.1(49.6‐136.8)
2.6(1.2‐4.6)
4.7(2.4‐8.0)
1.6(0.3‐3.9)
0.9(0.3‐2.1)
1.4(0.6‐3.0)
3.6(1.8‐6.8)
5.7(2.8‐10.6)
12.8(7.3‐22.9)
Asia, Central
29.2(18.6‐45.8)
67.3(42.5‐105.2)
43.6(27.7‐68.5)
2.1(0.9‐3.9)
3.9(2.1‐6.7)
1.5(0.2‐4.0)
0.7(0.2‐1.7)
0.8(0.3‐1.7)
2.2(1.0‐4.0)
3.6(1.6‐6.9)
8.4(4.8‐14.2)
Sub‐Saharan Africa, West
41.7(24.3‐74.1)
96.8(56.2‐172.0)
62.7(36.3‐111.2)
2.1(1.0‐4.0)
3.9(2.1‐7.4)
1.4(0.3‐3.5)
0.8(0.2‐1.8)
1.1(0.5‐2.3)
2.8(1.4‐5.2)
4.5(2.3‐8.6)
10.1(5.9‐18.0)
Sub‐Saharan Africa, Southern
62.2(25.8‐133.0)
145.4(60.3‐310.9)
93.9(39.0‐201.3)
2.3(0.9‐5.0)
4.2(1.8‐9.3)
1.6(0.3‐4.3)
0.9(0.2‐2.2)
1.4(0.5‐3.4)
3.8(1.5‐8.7)
6.2(2.4‐14.6)
Sub‐Saharan Africa, East
38.0(24.9‐57.9)
88.3(57.8‐135.1)
57.1(37.4‐87.2)
2.0(1.1‐3.2)
3.7(2.3‐5.7)
1.3(0.3‐3.0)
0.7(0.2‐1.5)
1.0(0.5‐1.9)
2.5(1.4‐4.1)
4.1(2.2‐6.7)
Sub‐Saharan Africa, Central
41.7(20.2‐81.0)
96.9(46.9‐188.1)
62.7(30.3‐121.9)
2.1(0.8‐4.5)
3.9(1.7‐7.8)
1.4(0.3‐3.8)
0.8(0.2‐1.9)
1.1(0.4‐2.4)
2.8(1.2‐6.0)
North Africa / Middle East
49.9(33.1‐73.9)
116.7(77.4‐173.4)
75.3(50.1‐111.8)
2.0(1.2‐2.9)
3.6(2.5‐5.2)
1.2(0.3‐2.5)
0.7(0.3‐1.4)
1.1(0.6‐1.9)
Asia, South
35.9(15.0‐82.4)
83.3(34.9‐191.3)
53.9(22.6‐123.9)
1.8(0.7‐3.9)
3.1(1.3‐6.8)
1.1(0.2‐2.9)
0.6(0.2‐1.8)
0.9(0.3‐2.5)
91.2(41.4‐183.1)
68.1(30.7‐137.1)
109.3(45.2‐229.3)
168.8(72.9‐357.2)
41.2(28.9‐56.8)
71.5(52.5‐95.3)
126.6(90.0‐174.7)
210.6(158.3‐282.0)
46.7(18.1‐109.6)
77.4(31.7‐177.5)
130.7(51.9‐283.0)
209.2(81.8‐457.7)
18.3(8.0‐38.4)
29.0(12.7‐63.3)
46.7(19.5‐104.6)
64.6(26.1‐152.8)
30.3(12.6‐66.1)
47.8(20.7‐102.9)
75.8(29.8‐166.0)
27.4(14.6‐49.2)
43.7(22.2‐81.2)
69.9(39.9‐126.3)
18.6(10.4‐32.4)
28.9(15.2‐50.6)
47.2(27.8‐79.4)
22.2(12.1‐40.7)
34.2(17.6‐65.0)
13.7(5.7‐31.4)
29.2(10.9‐65.5)
9.3(5.9‐14.0)
20.3(12.3‐32.7)
4.6(1.9‐9.7)
10.2(4.7‐20.1)
22.2(10.2‐43.5)
2.9(1.8‐4.4)
4.7(2.8‐7.2)
10.4(7.0‐15.1)
22.3(14.8‐33.6)
34.2(21.7‐52.5)
55.1(36.7‐81.7)
2.4(1.0‐5.5)
3.9(1.5‐8.8)
8.8(3.8‐19.5)
18.9(7.9‐43.8)
29.0(11.9‐68.2)
46.7(18.7‐109.0)
1,280.4(1,018.0‐1,585.9) 2,125.7(1,655.6‐2,675.6) 3,897.3(3,174.6‐4,733.1)
380.2(158.5‐767.9)
556.2(225.4‐1,175.3)
914.0(393.3‐1,897.4)
356.9(254.2‐492.2)
634.0(471.7‐844.1)
1,041.6(744.5‐1,428.7)
1,748.2(1,273.6‐2,371.1)
327.9(115.2‐744.6)
540.3(202.1‐1,174.8)
900.9(321.6‐2,094.8)
1,984.6(778.2‐4,367.7)
82.1(30.2‐203.4)
106.4(40.4‐260.5)
141.4(54.2‐347.5)
251.7(99.1‐603.9)
110.0(46.1‐234.1)
155.6(65.7‐324.5)
208.0(93.5‐433.9)
269.8(119.1‐601.8)
371.4(162.9‐786.0)
112.6(55.1‐224.1)
170.2(91.5‐312.6)
249.0(130.3‐442.5)
339.1(184.9‐594.5)
463.6(248.6‐818.0)
672.6(381.5‐1,169.4)
78.7(40.6‐139.6)
107.5(58.9‐179.5)
132.8(69.3‐238.3)
161.8(84.3‐292.0)
195.1(104.4‐333.7)
249.6(143.2‐417.6)
54.9(30.6‐98.7)
89.2(45.0‐166.1)
133.1(70.5‐244.2)
192.3(92.0‐370.3)
260.6(133.2‐504.8)
345.2(176.3‐649.2)
480.9(260.7‐874.5)
44.6(16.1‐101.5)
72.5(28.2‐163.2)
119.5(41.2‐273.8)
182.7(70.7‐419.7)
270.9(99.0‐650.3)
393.8(151.6‐927.3)
576.9(223.5‐1,250.5)
863.5(346.7‐1,913.4)
31.3(18.3‐52.0)
50.4(31.8‐79.2)
82.4(46.4‐136.6)
123.2(72.5‐198.7)
178.4(94.8‐316.7)
238.9(133.9‐407.1)
308.6(171.7‐514.1)
426.2(257.6‐665.1)
34.2(15.2‐67.4)
54.6(25.8‐108.9)
88.2(38.1‐179.9)
131.8(58.5‐264.7)
192.0(84.1‐401.5)
261.2(116.9‐531.1)
346.8(148.3‐699.0)
486.6(222.6‐948.3)
90.6(55.7‐143.0)
142.9(91.4‐226.3)
223.4(132.0‐351.6)
321.4(197.2‐495.0)
456.2(276.5‐708.7)
730.0(463.1‐1,136.8)
76.0(26.5‐182.2)
113.2(43.7‐258.5)
163.4(64.1‐374.0)
222.0(85.3‐499.8)
296.0(113.1‐686.2)
431.8(169.5‐1,015.3)
Oceania
126.6(64.3‐242.6)
299.0(152.1‐571.5)
192.4(97.6‐368.1)
2.3(1.0‐5.0)
4.4(2.0‐9.4)
2.0(0.5‐5.5)
1.2(0.3‐3.3)
2.1(0.9‐4.8)
5.5(2.5‐11.3)
8.8(3.8‐18.4)
19.0(9.1‐39.3)
40.3(19.2‐79.3)
62.1(28.8‐120.7)
297.6(140.8‐606.9)
479.2(219.9‐967.6)
800.4(381.1‐1,558.3)
1,373.1(643.6‐2,742.3)
Asia, Southeast
31.4(19.6‐50.8)
72.7(45.2‐117.7)
47.1(29.4‐76.2)
1.9(1.0‐3.2)
3.3(1.9‐5.6)
1.1(0.3‐2.7)
0.6(0.2‐1.5)
0.9(0.4‐2.1)
2.3(1.2‐4.0)
3.7(1.7‐6.7)
8.4(4.8‐14.2)
18.1(10.0‐30.5)
27.8(14.9‐47.5)
105.0(50.8‐203.6) 181.5(82.6‐382.8)
43.6(25.8‐72.5)
69.7(36.4‐116.1)
102.8(57.9‐171.4)
146.8(74.4‐261.8)
192.9(102.9‐342.3)
243.8(132.4‐416.0)
2,529.3(1,324.0‐4,844.3)
334.8(185.3‐542.1)
Asia, East
39.1(12.5‐96.7)
91.2(29.1‐226.1)
59.0(18.8‐146.0)
1.6(0.5‐4.1)
2.9(0.9‐7.2)
1.1(0.2‐3.2)
0.6(0.1‐1.8)
0.9(0.2‐2.6)
2.5(0.7‐6.2)
4.1(1.2‐10.4)
9.1(2.8‐22.9)
19.1(5.7‐47.4)
29.1(8.8‐71.8)
45.3(14.1‐112.3)
70.5(20.8‐196.6)
107.2(33.6‐267.9)
164.2(52.1‐397.3)
245.4(77.6‐614.4)
365.6(108.6‐945.8)
574.3(179.5‐1,403.2)
Latin America, Tropical
55.7(18.3‐136.5)
130.4(42.7‐320.0)
84.1(27.6‐206.0)
2.0(0.7‐5.1)
3.7(1.3‐9.2)
1.4(0.3‐4.4)
0.8(0.2‐2.4)
1.2(0.3‐3.0)
3.1(0.9‐7.5)
4.9(1.5‐12.5)
11.1(3.7‐27.2)
24.1(8.0‐59.9)
37.0(12.2‐95.0)
59.9(19.7‐150.0)
99.0(30.3‐257.8)
152.5(47.9‐379.3)
229.7(71.1‐622.3)
347.0(112.4‐903.8)
529.7(175.0‐1,312.1)
893.1(290.8‐2,226.1)
Latin America, Central
37.8(18.7‐71.0)
87.7(43.4‐163.6)
56.7(28.1‐106.3)
2.1(1.0‐4.2)
3.8(1.9‐7.5)
1.3(0.3‐3.5)
0.7(0.2‐1.7)
0.9(0.4‐2.2)
2.5(1.1‐4.9)
4.1(1.8‐8.3)
9.6(4.7‐18.1)
21.2(9.7‐40.8)
32.7(14.7‐63.5)
52.5(24.6‐96.9)
84.9(37.1‐159.7)
123.3(58.3‐232.1)
174.0(78.4‐354.7)
231.1(106.2‐467.0)
300.1(137.8‐585.3)
412.8(193.8‐813.0)
Latin America, Andean
44.4(20.2‐83.9)
103.1(47.2‐196.0)
66.7(30.4‐126.5)
2.2(0.9‐4.5)
4.1(1.8‐7.9)
1.5(0.3‐3.7)
0.8(0.2‐1.9)
1.1(0.4‐2.5)
2.9(1.2‐6.0)
4.7(1.9‐10.0)
10.8(4.8‐21.3)
23.4(9.9‐45.7)
36.0(14.7‐71.5)
57.7(25.0‐112.9)
93.9(39.4‐190.6)
139.8(62.1‐279.2)
201.4(84.6‐404.4)
276.2(115.3‐557.7)
372.6(159.3‐749.3)
527.3(229.9‐1,086.8)
Caribbean
69.7(40.3‐120.0)
163.2(93.8‐281.7)
105.4(60.7‐181.7)
2.5(1.2‐4.5)
4.5(2.4‐8.0)
1.7(0.4‐4.0)
1.0(0.3‐2.2)
1.6(0.7‐3.3)
4.0(2.0‐7.5)
6.4(3.1‐12.2)
14.2(8.1‐24.3)
30.1(16.8‐51.6)
46.1(25.3‐80.1)
75.3(43.5‐129.0)
125.6(61.4‐225.4)
195.6(104.1‐346.0)
298.7(153.4‐535.2)
443.2(234.6‐759.8)
657.4(341.8‐1,186.1)
1,070.5(577.7‐1,965.0)
Developed
90.4(77.8‐104.5)
212.4(182.7‐245.8) 136.8(117.7‐158.3) 2.8(2.2‐3.4)
5.1(4.2‐6.0)
1.8(1.1‐2.6)
1.0(0.6‐1.4)
1.7(1.3‐2.2)
4.4(3.5‐5.4)
7.1(5.7‐8.8)
15.3(12.9‐18.1)
32.6(26.9‐38.5)
50.3(41.1‐60.2)
84.1(69.8‐98.9)
141.3(115.1‐171.8) 227.9(192.6‐269.3)
364.3(299.8‐436.0)
563.6(475.0‐666.5)
916.1(759.8‐1,089.7)
1,657.6(1,409.8‐1,939.8)
Developing
40.0(27.2‐62.6)
93.1(63.0‐146.3)
60.2(40.8‐94.6)
1.9(1.4‐2.7)
3.4(2.6‐4.8)
1.2(0.8‐1.9)
0.7(0.4‐1.1)
1.0(0.7‐1.5)
2.6(1.9‐3.9)
4.2(3.0‐6.3)
9.4(6.5‐14.3)
20.0(13.3‐31.4)
30.7(20.4‐48.1)
48.8(32.8‐75.5)
78.1(52.0‐123.9)
118.1(80.3‐187.4)
175.5(117.9‐272.8)
248.5(165.6‐387.7)
351.0(231.2‐575.0)
540.5(360.4‐889.2)
Global
59.5(49.9‐74.9)
139.7(117.1‐175.3)
90.0(75.4‐113.1)
2.0(1.5‐2.7)
3.6(2.8‐4.9)
1.3(0.9‐1.9)
0.7(0.5‐1.1)
1.1(0.8‐1.6)
2.9(2.3‐4.0)
4.7(3.6‐6.5)
10.5(8.1‐14.5)
22.6(17.1‐31.7)
35.3(27.2‐48.8)
58.1(46.2‐78.7)
95.9(75.7‐130.0)
153.1(125.3‐200.9)
239.1(191.8‐305.7)
368.1(302.1‐462.5)
584.9(484.9‐725.3)
1,070.6(907.9‐1,289.2)
Supplemental Table 3b. Estimated age-standardized incidence rates of Atrial Fibrillation with 95% Uncertainty Intervals (per 100,000
person years) for all 21 GBD regions for males and females: 1990
GBD Region
North America, High Income
Latin America, Southern
Males
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
6.5(4.6‐8.6)
11.7(9.2‐14.6)
3.9(1.6‐6.9)
2.2(1.1‐3.9)
3.9(2.6‐6.0)
10.5(8.0‐13.8)
17.2(12.4‐22.6)
37.1(30.0‐45.5)
77.5(61.0‐97.4)
117.9(91.0‐150.9) 185.4(149.1‐225.8) 295.3(228.4‐371.4) 440.9(359.3‐538.4) 639.1(506.6‐791.0) 883.6(707.9‐1,073.1) 1,201.5(942.9‐1,491.4) 1,952.0(1,597.6‐2,357.6)
102.0(44.6‐207.1)
3.2(1.3‐6.7)
5.7(2.4‐11.7)
2.0(0.4‐5.1)
1.2(0.3‐2.9)
1.9(0.7‐4.1)
4.9(2.0‐10.2)
7.9(3.2‐17.0)
17.3(7.3‐35.0)
36.7(15.0‐75.8)
56.0(22.3‐114.8)
146.1(122.7‐172.5) 339.8(285.5‐401.7) 220.1(185.0‐260.1)
45‐49 years
50‐54 years
65‐69 years
70‐74 years
64.2(48.5‐85.5)
149.3(113.0‐198.7)
96.6(73.0‐128.6)
3.2(2.1‐4.9)
5.8(4.2‐8.1)
2.0(0.7‐3.8)
1.0(0.4‐1.9)
1.5(0.9‐2.6)
4.2(2.9‐6.0)
6.9(4.7‐10.0)
15.7(11.7‐21.2)
33.5(24.5‐46.9)
53.0(38.6‐75.0)
Australasia
77.9(30.9‐174.0)
181.3(71.8‐404.4)
117.3(46.5‐262.4)
3.4(1.3‐7.6)
6.2(2.5‐13.2)
2.3(0.5‐6.0)
1.4(0.4‐3.7)
2.0(0.7‐5.2)
5.2(1.9‐11.9)
8.3(3.0‐18.8)
18.6(7.0‐41.3)
39.6(14.4‐88.9)
60.6(21.8‐137.1)
Asia Pacific, High Income
33.3(12.9‐79.6)
77.4(29.8‐185.3)
50.1(19.4‐120.1)
1.6(0.6‐3.5)
2.8(1.1‐6.0)
0.9(0.2‐2.4)
0.6(0.2‐1.6)
1.0(0.3‐2.3)
2.4(1.0‐5.5)
3.9(1.6‐8.7)
9.4(3.7‐20.9)
20.7(8.0‐48.1)
32.0(12.3‐74.2)
50.8(19.9‐117.1)
82.0(30.5‐188.2)
115.2(42.6‐268.2)
150.7(54.0‐371.9)
187.0(69.0‐465.1)
224.3(80.2‐568.9)
356.1(131.0‐867.7)
Europe, Eastern
48.5(23.5‐98.7)
112.0(54.0‐227.2)
72.6(35.0‐147.4)
3.3(1.3‐7.3)
5.9(2.5‐12.8)
2.0(0.4‐5.7)
1.0(0.2‐2.7)
1.3(0.4‐3.1)
3.4(1.3‐7.8)
5.6(2.1‐13.1)
13.4(5.8‐28.2)
30.0(12.9‐63.7)
47.3(20.3‐99.3)
74.3(34.8‐162.3)
115.8(50.5‐263.3)
164.1(74.3‐364.4)
221.3(92.1‐452.1)
286.1(122.5‐575.6)
359.2(149.1‐752.6)
463.7(213.3‐940.5)
Europe, Central
75.0(46.9‐123.7)
174.2(108.7‐287.2) 112.8(70.5‐185.9)
3.9(2.0‐7.1)
7.0(4.0‐12.2)
2.4(0.5‐6.6)
1.3(0.3‐3.2)
1.9(0.9‐4.2)
5.3(2.8‐10.4)
8.6(4.2‐16.9)
19.3(11.2‐34.2)
41.3(23.2‐69.8)
62.3(33.2‐105.3)
99.7(57.3‐169.7)
162.8(82.2‐301.7) 242.8(131.0‐424.4) 349.7(178.3‐601.9)
472.4(258.0‐801.8)
603.1(335.6‐1,038.7)
837.0(483.4‐1,428.0)
Asia, Central
47.5(30.4‐71.1)
109.8(70.4‐164.4)
71.1(45.5‐106.5)
3.1(1.5‐5.4)
5.7(3.1‐9.4)
2.0(0.4‐5.2)
1.0(0.3‐2.3)
1.2(0.5‐2.5)
3.2(1.6‐6.0)
5.2(2.5‐9.9)
13.5(7.9‐22.7)
32.2(17.9‐53.7)
51.6(28.2‐86.7)
78.4(46.2‐124.9)
116.1(60.9‐205.7)
159.7(87.8‐269.1) 210.4(115.8‐356.9)
270.2(149.6‐453.5)
339.5(191.8‐556.2)
437.4(247.9‐719.3)
Sub‐Saharan Africa, West
49.2(30.3‐85.3)
113.8(70.1‐198.4)
73.6(45.4‐127.9)
3.2(1.5‐6.0)
6.1(3.5‐11.1)
2.2(0.4‐5.6)
1.1(0.3‐2.6)
1.2(0.5‐2.8)
3.2(1.6‐6.1)
5.3(2.5‐10.1)
12.7(7.2‐22.6)
28.7(16.4‐52.3)
44.8(24.7‐82.5)
71.4(41.3‐130.0)
114.9(59.5‐217.0)
166.6(93.3‐298.2) 231.8(124.5‐419.0)
300.1(160.0‐548.3)
374.8(197.3‐684.4)
482.5(259.6‐902.7)
Sub‐Saharan Africa, Southern
61.2(27.4‐132.2)
141.9(63.3‐306.5)
91.9(41.1‐198.6)
3.2(1.3‐7.1)
5.9(2.6‐13.1)
2.2(0.4‐6.2)
1.2(0.3‐3.2)
1.6(0.6‐4.0)
4.3(1.8‐9.2)
7.0(2.7‐15.7)
16.0(6.7‐34.8)
35.4(13.6‐81.0)
54.5(21.0‐126.4)
86.4(35.6‐195.2)
139.0(54.5‐321.4)
203.1(84.0‐459.3) 286.1(110.9‐660.9)
373.0(154.5‐838.6)
472.3(201.9‐1,035.0)
642.9(282.9‐1,346.8)
Sub‐Saharan Africa, East
52.1(34.1‐77.0)
120.6(78.4‐179.5)
78.1(50.9‐115.7)
3.2(1.7‐5.3)
6.0(3.7‐9.3)
2.1(0.5‐5.2)
1.1(0.3‐2.3)
1.3(0.6‐2.8)
3.5(1.9‐5.9)
5.8(3.1‐9.9)
13.6(8.7‐21.1)
30.3(18.5‐49.4)
47.0(27.4‐79.1)
74.7(46.7‐118.4)
119.4(64.9‐200.9) 174.4(103.6‐279.2) 246.2(141.0‐414.0)
320.2(182.3‐530.7)
399.5(222.8‐657.3)
522.6(316.0‐820.5)
Sub‐Saharan Africa, Central
56.8(28.1‐110.7)
131.6(65.1‐255.9)
85.1(42.2‐166.3)
3.3(1.3‐7.2)
6.3(2.7‐13.2)
2.1(0.3‐5.8)
1.1(0.3‐2.8)
1.4(0.5‐3.3)
3.7(1.5‐7.9)
6.0(2.4‐12.9)
14.3(6.6‐28.5)
32.0(13.5‐66.4)
49.8(20.7‐105.6)
79.3(36.9‐162.3)
127.7(52.6‐270.5)
353.5(160.1‐744.6)
445.0(201.5‐907.8)
585.5(284.7‐1,166.4)
North Africa / Middle East
62.0(40.3‐93.5)
144.0(92.9‐217.0)
93.3(60.5‐140.3)
3.2(1.9‐5.3)
5.7(3.6‐8.9)
1.8(0.5‐3.8)
1.0(0.4‐2.1)
1.6(0.8‐3.0)
4.4(2.5‐7.0)
7.1(4.0‐11.7)
16.0(10.0‐24.7)
35.0(21.1‐56.4)
53.6(31.9‐87.0)
85.0(51.9‐135.0)
135.4(78.3‐228.8) 200.2(122.5‐320.4) 286.8(161.3‐474.1)
381.5(228.8‐624.0)
488.1(280.7‐781.2)
698.3(425.7‐1,109.4)
Asia, South
47.7(19.3‐103.4)
110.3(44.7‐239.7)
71.5(28.9‐155.4)
2.8(1.1‐5.8)
5.1(2.0‐10.9)
1.7(0.3‐4.8)
0.9(0.2‐2.4)
1.2(0.4‐3.0)
3.4(1.2‐7.6)
5.7(2.0‐12.3)
13.0(4.8‐27.9)
28.4(10.9‐63.0)
43.8(16.6‐97.9)
69.7(27.2‐153.7)
112.0(41.3‐249.9)
225.2(82.7‐516.2)
288.5(109.0‐645.2)
353.3(135.7‐805.9)
468.2(179.1‐1,050.1)
Oceania
71.3(39.0‐129.9)
166.0(91.1‐302.0)
107.4(58.8‐195.4)
2.8(1.3‐5.8)
5.3(2.6‐10.6)
2.1(0.5‐5.3)
1.2(0.4‐3.0)
1.8(0.7‐4.4)
4.8(2.3‐9.9)
7.7(3.4‐15.9)
16.5(7.8‐32.6)
34.8(16.2‐68.8)
53.3(24.1‐106.4)
86.2(41.7‐163.8)
143.0(61.8‐293.8) 216.1(104.9‐422.3) 317.8(158.0‐642.7)
445.0(230.4‐854.4)
624.8(316.0‐1,126.3)
941.9(497.8‐1,713.5)
Asia, Southeast
46.7(28.9‐77.0)
107.9(66.7‐178.5)
69.9(43.2‐115.5)
3.0(1.5‐5.2)
5.5(3.2‐9.1)
2.0(0.4‐5.0)
1.0(0.3‐2.3)
1.3(0.6‐2.8)
3.5(1.8‐6.6)
5.8(2.7‐10.7)
13.5(7.7‐22.6)
30.1(17.1‐52.6)
46.8(25.5‐83.4)
71.9(41.5‐124.7)
110.1(57.0‐202.1)
155.6(88.0‐268.9) 214.3(110.2‐367.4)
277.0(148.9‐473.1)
342.8(183.2‐608.2)
441.6(246.3‐771.2)
Asia, East
46.4(14.6‐116.2)
107.5(33.6‐269.0)
69.7(21.9‐174.5)
2.5(0.8‐6.5)
4.6(1.4‐11.4)
1.6(0.3‐4.5)
0.8(0.2‐2.5)
1.2(0.3‐3.3)
3.3(1.0‐8.3)
5.5(1.6‐13.5)
12.3(3.8‐29.6)
26.3(8.4‐67.0)
40.7(12.9‐104.9)
65.4(21.2‐166.3)
105.8(33.4‐262.7)
155.0(48.6‐365.2)
218.3(68.2‐538.1)
283.6(84.6‐696.6)
353.3(107.7‐945.1)
487.4(148.1‐1,240.9)
Latin America, Tropical
60.2(20.1‐139.9)
139.6(46.5‐323.9)
90.4(30.3‐210.5)
3.2(1.0‐7.9)
5.8(1.8‐13.8)
1.9(0.3‐6.1)
1.2(0.2‐3.5)
1.7(0.4‐4.9)
4.3(1.3‐10.5)
6.8(2.0‐17.2)
15.5(5.1‐37.8)
33.9(11.2‐84.1)
52.4(17.2‐130.9)
83.4(27.9‐203.6)
134.3(40.5‐332.1)
197.1(62.8‐481.6)
278.8(90.2‐694.9)
367.9(118.1‐916.2)
469.6(149.8‐1,130.0)
660.7(216.2‐1,622.1)
Latin America, Central
55.4(29.7‐97.6)
127.7(68.5‐225.8)
82.8(44.4‐146.3)
3.6(1.6‐7.2)
6.6(3.4‐12.6)
2.4(0.5‐6.4)
1.3(0.3‐3.5)
1.5(0.6‐3.8)
4.2(1.9‐7.9)
6.8(3.0‐13.2)
15.4(7.9‐28.3)
33.6(17.4‐60.8)
51.7(25.6‐96.8)
82.3(43.6‐147.1)
133.0(62.2‐253.0)
191.9(96.3‐347.3) 263.9(125.8‐506.1)
332.9(159.1‐643.9)
399.5(194.9‐762.6)
511.6(250.9‐943.1)
Latin America, Andean
61.5(30.9‐111.0)
142.6(71.8‐257.5)
92.3(46.3‐166.7)
3.5(1.5‐6.7)
6.4(3.0‐12.2)
2.2(0.5‐5.5)
1.2(0.3‐2.8)
1.6(0.6‐3.7)
4.4(1.8‐8.7)
7.1(2.8‐14.3)
16.0(7.6‐30.0)
34.8(16.2‐66.3)
53.7(24.2‐105.4)
85.6(41.1‐162.8)
138.1(59.6‐265.1)
203.2(95.1‐375.8) 288.8(124.9‐554.3)
380.0(164.1‐699.9)
481.3(217.6‐977.9)
647.0(291.8‐1,227.5)
Caribbean
79.6(46.0‐133.9)
184.9(106.5‐311.0) 119.7(69.4‐201.1)
3.9(2.0‐6.7)
7.1(4.0‐12.1)
2.5(0.6‐5.7)
1.4(0.4‐3.1)
2.1(0.9‐4.5)
5.5(2.8‐10.0)
8.9(4.4‐16.2)
19.6(11.3‐34.2)
42.1(24.0‐74.2)
64.6(35.5‐117.7)
103.0(57.6‐178.4)
166.9(84.1‐307.8) 250.8(138.4‐449.1) 365.7(191.1‐678.4)
499.2(265.7‐889.7)
664.1(329.7‐1,147.0)
941.8(494.5‐1,629.7)
Developed
78.4(67.5‐91.9)
182.1(156.9‐213.4) 117.9(101.6‐138.2)
4.0(3.2‐5.1)
7.0(5.7‐8.6)
2.3(1.4‐3.5)
1.3(0.8‐1.9)
2.0(1.5‐2.7)
5.5(4.4‐6.8)
9.1(7.2‐11.4)
20.1(16.8‐24.2)
42.2(35.1‐50.9)
64.2(53.2‐77.6)
98.4(81.7‐119.3)
156.7(126.1‐197.1) 236.5(196.1‐293.6) 357.5(296.9‐432.6)
502.1(421.3‐596.5)
653.2(546.5‐781.6)
965.3(823.1‐1,131.3)
Developing
50.0(33.8‐76.8)
115.8(78.1‐178.8)
75.0(50.7‐115.5)
2.9(2.1‐4.3)
5.4(3.9‐7.7)
1.8(1.1‐3.0)
1.0(0.6‐1.5)
1.3(0.8‐2.2)
3.6(2.4‐5.4)
5.9(3.9‐9.0)
13.4(9.0‐20.5)
29.2(19.8‐44.9)
45.2(30.5‐69.3)
71.7(48.2‐109.4)
114.5(74.9‐177.7) 166.7(109.8‐254.8) 233.7(149.8‐376.6)
303.1(196.4‐489.3)
379.2(253.9‐621.6)
515.7(344.9‐825.3)
Global
60.7(49.2‐78.5)
141.0(114.6‐182.6)
91.2(74.1‐118.2)
3.1(2.3‐4.2)
5.6(4.3‐7.7)
1.9(1.2‐2.9)
1.0(0.7‐1.5)
1.4(1.1‐2.2)
4.0(3.1‐5.5)
6.6(5.1‐9.1)
15.1(11.7‐20.5)
33.0(25.9‐44.3)
50.8(39.8‐68.3)
80.1(62.8‐105.4)
128.2(97.8‐172.1) 191.3(149.8‐252.2) 278.8(217.9‐369.6)
375.0(297.6‐493.8)
494.4(405.3‐644.5)
719.1(603.5‐900.9)
Females
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
70‐74 years
75‐79 years
80+ years
4.0(2.9‐5.3)
7.3(5.7‐9.1)
2.5(1.0‐4.3)
1.4(0.6‐2.4)
2.5(1.6‐3.8)
6.8(5.1‐8.8)
11.1(8.1‐14.7)
23.2(18.7‐28.9)
47.3(37.8‐58.9)
71.5(55.8‐91.3)
111.0(90.7‐135.1) 174.3(134.2‐221.5) 269.0(219.4‐330.1) 409.6(323.6‐525.8)
623.1(501.9‐767.5)
951.4(750.8‐1,181.8)
1,618.2(1,330.2‐1,962.5)
0.7(0.2‐1.9)
1.1(0.4‐2.6)
3.0(1.3‐6.2)
4.8(1.8‐10.0)
10.8(4.8‐20.9)
23.2(9.9‐46.5)
35.6(15.1‐73.4)
57.0(25.5‐117.4)
276.6(112.8‐582.2)
373.1(152.3‐828.9)
539.7(231.5‐1,104.9)
Latin America, Southern
417.0(174.9‐881.5)
85.0(64.4‐113.7)
132.9(93.5‐189.0) 202.1(148.0‐276.3) 301.3(206.4‐420.1)
409.7(285.4‐564.6)
96.3(37.8‐216.5)
155.2(55.0‐351.6)
55‐59 years
92.7(38.7‐197.1)
242.4(92.6‐542.6) 372.1(145.2‐852.1) 502.9(193.1‐1,124.8)
188.5(81.8‐387.3) 269.2(118.1‐594.1)
162.3(62.2‐361.2)
60‐64 years
138.7(59.3‐296.8)
65‐69 years
200.8(81.7‐435.1)
561.7(218.1‐1,217.9)
80+ years
Europe, Western
101.2(86.3‐120.8) 236.1(201.1‐281.4) 152.8(130.3‐182.2)
211.0(89.7‐432.9) 304.1(125.6‐625.8)
75‐79 years
157.5(68.5‐320.2)
North America, High Income
142.3(56.5‐290.2)
60‐64 years
67.8(29.7‐137.7)
GBD Region
88.6(39.5‐181.8)
55‐59 years
825.0(350.9‐1,749.6)
547.9(390.6‐769.1)
727.6(531.2‐1,007.2)
635.6(236.0‐1,424.3)
962.7(363.6‐2,210.8)
44.3(20.1‐91.4)
103.1(46.7‐212.8)
66.7(30.3‐137.4)
2.0(0.8‐4.3)
3.6(1.5‐7.4)
1.3(0.3‐3.3)
Europe, Western
49.3(36.5‐67.4)
115.1(85.2‐157.8)
74.3(55.0‐101.7)
2.1(1.3‐3.2)
3.8(2.7‐5.4)
1.4(0.5‐2.6)
0.7(0.3‐1.2)
1.0(0.5‐1.6)
2.7(1.8‐4.0)
4.5(2.9‐6.6)
10.2(7.4‐14.0)
21.6(15.4‐30.4)
33.6(23.7‐47.0)
54.0(40.0‐74.4)
86.4(58.8‐125.4)
132.2(93.4‐187.1) 197.4(134.8‐285.4)
312.4(222.1‐446.8)
514.1(354.9‐720.0)
741.5(533.2‐1,033.9)
Australasia
60.8(24.9‐131.6)
142.4(58.4‐308.6)
91.9(37.6‐198.9)
2.2(0.9‐4.9)
3.9(1.6‐8.6)
1.4(0.3‐3.8)
0.8(0.2‐2.1)
1.3(0.4‐3.3)
3.4(1.3‐8.1)
5.6(2.1‐12.9)
12.3(5.0‐26.9)
26.2(10.5‐57.8)
40.0(15.8‐90.7)
65.7(26.5‐143.2)
109.9(41.0‐251.0)
174.3(69.1‐387.9) 268.8(105.4‐616.7)
384.8(153.5‐883.8)
535.7(208.6‐1,205.8)
948.8(393.0‐2,077.1)
Asia Pacific, High Income
21.2(8.1‐46.6)
49.3(18.7‐108.6)
31.9(12.1‐70.4)
1.0(0.4‐2.1)
1.7(0.7‐3.7)
0.6(0.1‐1.4)
0.4(0.1‐1.0)
0.6(0.2‐1.4)
1.4(0.5‐3.2)
2.2(0.8‐5.1)
5.7(2.3‐13.2)
13.2(5.2‐30.0)
20.6(8.2‐47.2)
32.0(13.0‐71.9)
49.8(18.5‐116.9)
69.4(26.0‐161.0)
91.9(32.8‐218.1)
118.2(40.9‐280.5)
150.9(53.5‐354.0)
248.5(90.0‐585.3)
Europe, Eastern
29.3(13.0‐58.8)
67.8(30.0‐135.5)
43.9(19.4‐87.6)
2.0(0.8‐4.6)
3.5(1.5‐7.7)
1.2(0.2‐3.2)
0.6(0.1‐1.6)
0.8(0.3‐2.0)
1.9(0.8‐4.4)
3.1(1.1‐7.1)
7.7(3.2‐16.6)
17.4(7.4‐37.5)
27.5(11.7‐58.8)
44.0(19.1‐92.0)
69.8(27.8‐146.1)
100.0(41.9‐202.2)
135.3(55.2‐285.0)
175.3(70.6‐362.7)
220.9(87.0‐478.1)
284.8(115.3‐626.9)
Europe, Central
41.2(24.5‐75.1)
95.5(56.8‐173.9)
61.8(36.8‐113.0)
2.3(1.1‐4.6)
4.2(2.3‐8.1)
1.5(0.3‐3.6)
0.8(0.2‐1.9)
1.0(0.4‐2.3)
2.9(1.4‐5.6)
4.7(2.2‐9.2)
10.8(5.8‐20.4)
23.4(12.8‐44.3)
35.4(19.0‐67.4)
56.5(31.9‐104.0)
91.4(44.7‐167.4)
135.0(70.1‐246.1)
190.2(95.1‐352.0)
253.8(127.6‐473.9)
323.5(165.9‐613.3)
448.9(238.8‐808.1)
Asia, Central
28.7(17.7‐46.1)
66.2(40.5‐106.8)
42.9(26.4‐69.5)
1.9(0.9‐3.4)
3.5(2.0‐5.9)
1.4(0.2‐3.6)
0.7(0.2‐1.7)
0.8(0.3‐1.7)
2.2(1.0‐4.0)
3.6(1.6‐6.6)
8.2(4.5‐13.5)
18.1(9.6‐30.4)
28.5(14.4‐49.5)
47.2(26.9‐80.2)
77.9(39.1‐141.6)
107.4(56.2‐190.1)
131.9(68.3‐236.3)
159.4(78.2‐282.9)
190.4(99.4‐332.9)
238.4(123.3‐406.0)
Sub‐Saharan Africa, West
38.9(22.9‐68.5)
90.2(53.0‐159.3)
58.4(34.4‐103.2)
2.0(1.0‐3.9)
3.8(2.1‐7.0)
1.3(0.3‐3.3)
0.7(0.2‐1.7)
1.0(0.4‐2.1)
2.7(1.4‐4.9)
4.4(2.2‐8.1)
9.9(5.7‐17.4)
21.6(11.9‐39.2)
33.2(17.9‐61.7)
52.7(30.2‐92.3)
84.7(43.2‐155.1)
125.3(68.1‐226.6)
179.9(93.2‐339.4)
240.6(127.4‐459.9)
312.6(155.7‐576.7)
432.2(227.5‐791.4)
Sub‐Saharan Africa, Southern
51.2(21.3‐105.3)
119.2(49.3‐244.8)
77.1(31.9‐158.5)
2.2(0.9‐5.0)
4.0(1.7‐8.2)
1.5(0.3‐3.9)
0.8(0.2‐2.3)
1.3(0.5‐3.2)
3.4(1.3‐7.3)
5.5(2.0‐11.8)
12.3(5.0‐24.7)
26.6(10.5‐57.6)
40.9(15.7‐89.2)
65.5(25.9‐142.9)
106.6(40.2‐240.2)
159.6(63.3‐351.7)
232.7(89.5‐504.4)
320.5(128.4‐689.5)
435.1(167.7‐939.4)
625.6(253.5‐1,319.1)
Sub‐Saharan Africa, East
38.6(26.0‐57.5)
89.7(60.2‐133.6)
58.0(38.9‐86.6)
2.0(1.1‐3.3)
3.8(2.3‐5.9)
1.4(0.3‐3.0)
0.7(0.3‐1.5)
0.9(0.5‐1.9)
2.6(1.5‐4.3)
4.2(2.3‐7.1)
9.7(6.1‐14.5)
21.3(12.9‐32.6)
32.9(19.4‐51.8)
52.8(34.0‐80.4)
85.9(47.5‐139.1)
126.7(75.3‐198.6)
180.4(98.0‐292.6)
239.3(137.1‐380.7)
308.1(176.1‐487.9)
421.4(265.1‐653.8)
Sub‐Saharan Africa, Central
37.6(18.1‐77.6)
87.4(41.8‐179.9)
56.5(27.2‐116.7)
1.9(0.7‐4.1)
3.7(1.6‐8.1)
1.3(0.2‐3.7)
0.7(0.2‐2.0)
1.0(0.4‐2.3)
2.5(1.0‐5.6)
4.1(1.6‐9.1)
9.4(4.3‐19.9)
20.7(8.9‐44.7)
31.9(13.2‐69.7)
50.8(22.6‐107.5)
81.9(34.4‐180.1)
121.6(53.0‐263.3)
175.3(74.0‐382.4)
234.6(101.9‐498.6)
304.3(132.8‐606.4)
417.4(191.6‐840.4)
North Africa / Middle East
42.0(28.4‐63.7)
97.8(66.0‐148.6)
63.2(42.7‐96.0)
1.9(1.1‐3.0)
3.5(2.2‐5.3)
1.2(0.3‐2.5)
0.7(0.3‐1.4)
1.0(0.6‐1.9)
2.7(1.7‐4.3)
4.4(2.6‐7.2)
9.9(6.4‐15.4)
21.7(13.6‐33.6)
33.3(20.6‐52.4)
52.8(34.5‐81.3)
85.5(50.6‐139.6)
128.0(80.2‐203.4) 189.1(110.0‐306.4)
262.5(160.8‐416.2)
359.0(214.0‐570.9)
533.2(341.1‐833.4)
Asia, South
31.0(12.9‐72.4)
71.9(29.8‐168.4)
46.6(19.3‐108.6)
1.7(0.7‐3.8)
3.1(1.3‐6.9)
1.1(0.2‐3.2)
0.6(0.2‐1.7)
0.8(0.3‐2.1)
2.2(0.9‐5.3)
3.6(1.3‐8.7)
8.2(3.2‐18.9)
17.9(6.9‐40.2)
27.6(10.5‐62.5)
44.0(17.7‐105.4)
70.7(27.5‐172.5)
102.9(41.9‐248.6)
144.0(55.7‐335.6)
187.6(74.8‐430.8)
236.0(93.4‐570.1)
331.5(130.1‐791.3)
Oceania
37.2(19.6‐72.8)
86.6(45.6‐169.9)
56.1(29.5‐109.6)
1.7(0.7‐3.7)
3.2(1.5‐6.5)
1.2(0.3‐2.9)
0.7(0.2‐1.6)
0.9(0.4‐2.2)
2.6(1.2‐5.2)
4.1(1.8‐8.6)
9.2(4.7‐18.4)
20.0(9.6‐40.2)
30.8(14.6‐62.6)
49.1(24.0‐100.2)
79.7(35.6‐169.1)
118.7(56.1‐250.1)
171.9(83.3‐346.2)
231.7(113.6‐470.1)
304.6(147.3‐608.8)
434.8(220.1‐841.9)
Asia, Southeast
29.3(17.0‐48.9)
67.7(39.5‐113.7)
43.9(25.6‐73.5)
1.9(0.9‐3.3)
3.4(1.9‐5.9)
1.2(0.3‐3.0)
0.6(0.2‐1.4)
0.8(0.4‐1.7)
2.2(1.1‐4.0)
3.6(1.7‐6.5)
8.2(4.7‐13.8)
18.4(10.1‐31.7)
28.6(14.6‐51.3)
43.8(25.2‐78.2)
67.0(35.6‐129.1)
96.1(53.8‐175.1)
135.5(68.2‐243.9)
176.6(93.8‐306.8)
219.1(118.9‐382.8)
287.7(157.0‐503.7)
Asia, East
37.5(12.7‐85.8)
87.2(29.6‐199.8)
56.5(19.2‐129.1)
1.7(0.5‐3.8)
3.0(1.0‐6.9)
1.0(0.2‐2.9)
0.6(0.1‐1.7)
1.0(0.3‐2.6)
2.6(0.8‐6.2)
4.2(1.4‐10.0)
9.1(3.0‐21.3)
19.0(6.3‐44.8)
29.1(9.6‐69.6)
46.9(16.2‐108.9)
76.4(24.4‐186.5)
114.1(37.4‐271.0)
165.4(53.7‐394.5)
229.6(74.7‐525.9)
315.4(105.6‐745.8)
496.4(164.9‐1,146.9)
Latin America, Tropical
41.7(14.0‐96.7)
97.0(32.6‐225.5)
62.8(21.0‐145.6)
2.0(0.7‐4.9)
3.6(1.2‐8.6)
1.2(0.2‐3.8)
0.7(0.2‐2.1)
1.1(0.3‐2.9)
2.8(0.9‐7.0)
4.4(1.3‐11.5)
10.1(3.3‐25.4)
21.9(7.0‐55.5)
33.9(10.5‐86.8)
54.1(17.3‐128.2)
87.3(26.0‐211.4)
130.6(40.5‐319.2)
189.4(59.1‐459.5)
259.5(84.3‐625.4)
348.3(114.7‐859.6)
Latin America, Central
35.8(18.0‐69.0)
82.7(41.7‐160.2)
53.6(27.0‐103.7)
2.1(1.0‐4.3)
4.0(2.0‐7.5)
1.5(0.3‐4.0)
0.7(0.2‐1.8)
0.9(0.4‐2.0)
2.6(1.1‐5.5)
4.4(1.8‐9.0)
10.2(4.9‐19.6)
22.5(10.7‐42.7)
34.9(16.2‐67.4)
55.2(27.5‐105.6)
88.3(40.4‐172.7)
124.1(58.6‐240.4)
164.4(71.5‐328.1)
207.3(92.1‐409.5)
257.2(118.3‐540.8)
506.4(169.3‐1,259.3)
335.9(155.5‐681.1)
Latin America, Andean
40.3(19.8‐76.8)
93.5(45.9‐178.6)
60.5(29.7‐115.7)
2.1(0.9‐4.3)
3.9(1.8‐7.4)
1.4(0.3‐3.5)
0.7(0.2‐2.1)
1.0(0.4‐2.4)
2.7(1.2‐5.5)
4.4(1.8‐8.5)
10.1(4.9‐19.2)
22.1(10.2‐43.6)
34.3(15.4‐68.4)
54.8(27.4‐106.5)
88.8(38.7‐178.5)
131.0(61.2‐255.9)
186.7(82.2‐393.6)
249.9(110.0‐501.0)
325.8(137.6‐663.2)
441.8(200.2‐871.1)
Caribbean
56.8(32.7‐96.8)
132.4(75.8‐226.1)
85.5(49.3‐146.1)
2.4(1.2‐4.4)
4.5(2.4‐7.8)
1.7(0.4‐3.9)
0.9(0.3‐2.1)
1.3(0.6‐2.6)
3.5(1.8‐6.4)
5.7(2.7‐10.7)
12.8(7.2‐22.1)
27.8(15.3‐49.4)
43.1(22.4‐77.2)
69.2(37.5‐119.4)
113.0(57.0‐207.8)
171.6(93.2‐300.0) 253.9(126.6‐460.6)
360.1(190.5‐647.1)
505.1(262.8‐932.5)
737.6(408.9‐1,356.4)
Developed
52.8(45.0‐62.9)
123.0(104.5‐146.2)
79.6(67.7‐94.7)
2.5(1.9‐3.1)
4.3(3.5‐5.4)
1.5(0.9‐2.2)
0.8(0.5‐1.1)
1.2(0.9‐1.7)
3.5(2.8‐4.3)
5.7(4.5‐7.1)
12.4(10.4‐15.0)
26.0(21.5‐31.5)
39.3(32.3‐47.6)
59.7(49.8‐73.9)
95.0(77.1‐119.4)
144.0(119.2‐177.7) 217.3(175.7‐265.8)
333.5(278.7‐402.0)
494.5(409.1‐607.1)
779.8(654.7‐921.9)
Developing
36.0(24.5‐54.7)
83.7(56.6‐127.4)
54.2(36.7‐82.4)
1.8(1.3‐2.6)
3.3(2.5‐4.7)
1.2(0.7‐2.0)
0.6(0.4‐1.0)
0.9(0.6‐1.5)
2.5(1.7‐3.7)
4.0(2.7‐6.1)
9.1(6.2‐13.7)
19.5(13.3‐29.1)
30.1(20.3‐45.2)
47.9(32.8‐71.0)
77.1(51.8‐118.8)
113.8(76.9‐172.1) 162.5(109.0‐253.5)
220.0(146.0‐346.0)
292.1(188.0‐463.9)
432.2(274.0‐716.9)
Global
43.8(35.9‐55.0)
102.0(83.9‐127.9)
65.9(54.2‐82.8)
1.9(1.5‐2.6)
3.5(2.7‐4.6)
1.2(0.8‐1.9)
0.7(0.4‐1.0)
1.0(0.7‐1.5)
2.7(2.0‐3.7)
4.4(3.4‐6.0)
9.9(7.7‐13.5)
21.5(16.7‐28.4)
32.9(25.5‐43.7)
51.8(41.0‐67.2)
83.4(64.5‐111.6)
125.7(100.0‐161.3) 186.0(149.0‐243.4)
269.6(219.7‐350.4)
395.6(325.3‐494.2)
624.8(517.1‐775.7)
Supplemental Table 4a. Estimated age-standardized mortality rates associated with Atrial Fibrillation with 95% Uncertainty Intervals (per
100,000) for all 21 GBD regions for males and females: 2010
GBD Region
Males
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
40‐44 years
45‐49 years
75‐79 years
80+ years
North America, High Income
2.8(1.5‐5.7)
6.8(3.6‐13.7)
4.4(2.3‐8.7)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
Latin America, Southern
2.0(1.4‐2.9)
4.8(3.2‐7.0)
3.1(2.1‐4.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.6)
0.5(0.2‐1.3)
0.1(0.0‐0.1)
0.1(0.1‐0.3)
0.3(0.1‐0.5)
0.6(0.3‐1.0)
12.8(5.4‐28.0)
27.5(12.0‐57.7)
117.8(48.4‐257.7)
10.7(6.1‐18.3)
23.0(13.5‐36.2)
66.6(39.3‐109.5)
Europe, Western
3.4(2.2‐4.8)
8.2(5.3‐11.6)
5.2(3.4‐7.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.3(0.2‐0.5)
0.6(0.4‐1.2)
15.1(9.2‐23.7)
35.8(21.8‐56.7)
139.5(86.1‐203.1)
Australasia
3.4(1.8‐5.9)
8.1(4.3‐14.2)
5.2(2.8‐9.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
Asia Pacific, High Income
2.4(1.3‐4.5)
5.9(3.0‐10.8)
3.7(1.9‐6.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.1)
0.2(0.1‐0.4)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
5.2(2.0‐11.1)
12.6(5.2‐24.0)
32.2(13.3‐62.9)
152.8(68.6‐284.4)
5.7(2.6‐11.7)
12.1(5.2‐26.2)
25.1(10.1‐55.4)
Europe, Eastern
0.4(0.2‐0.7)
1.1(0.5‐1.8)
0.7(0.3‐1.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
94.7(39.6‐180.7)
1.2(0.4‐3.4)
1.8(0.8‐3.6)
2.5(1.1‐5.0)
4.9(2.0‐10.2)
Europe, Central
1.6(1.1‐2.2)
3.9(2.5‐5.4)
2.5(1.6‐3.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.1‐0.1)
9.9(4.0‐20.5)
1.5(0.8‐2.4)
3.0(1.8‐4.8)
5.6(3.3‐8.5)
9.6(5.7‐14.3)
19.6(11.4‐29.9)
45.2(27.1‐67.9)
Asia, Central
0.3(0.2‐0.4)
0.7(0.5‐1.0)
0.4(0.3‐0.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
Sub‐Saharan Africa, West
0.4(0.1‐1.0)
0.9(0.3‐2.5)
0.6(0.2‐1.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.4(0.2‐0.8)
0.5(0.3‐1.1)
1.0(0.5‐2.0)
1.0(0.5‐1.9)
1.8(1.0‐3.0)
2.4(1.0‐4.5)
4.8(2.7‐7.8)
0.2(0.1‐0.4)
0.3(0.1‐0.9)
0.8(0.2‐2.1)
1.2(0.4‐3.4)
2.4(0.8‐6.5)
4.5(1.4‐13.3)
10.1(3.1‐31.8)
Sub‐Saharan Africa, Southern
2.1(1.1‐4.0)
5.1(2.6‐9.7)
3.2(1.7‐6.2)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
Sub‐Saharan Africa, East
0.3(0.1‐1.0)
0.8(0.3‐2.3)
0.5(0.2‐1.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.4(0.1‐0.9)
0.9(0.3‐2.0)
2.0(0.7‐4.6)
3.6(1.3‐8.3)
6.3(2.4‐13.2)
11.6(4.6‐24.1)
23.7(9.1‐51.3)
65.7(26.0‐131.4)
0.1(0.0‐0.2)
0.2(0.1‐0.5)
0.3(0.1‐0.9)
0.7(0.2‐2.1)
1.2(0.4‐3.5)
2.3(0.7‐6.4)
3.9(1.2‐10.6)
Sub‐Saharan Africa, Central
0.3(0.1‐1.0)
0.7(0.2‐2.5)
0.5(0.1‐1.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
8.9(2.6‐29.2)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.0‐0.6)
0.4(0.1‐1.2)
0.8(0.2‐2.7)
1.1(0.3‐3.5)
2.1(0.5‐6.4)
3.4(0.8‐10.7)
7.7(2.0‐30.8)
North Africa / Middle East
1.7(1.0‐2.8)
4.1(2.5‐6.8)
2.6(1.6‐4.3)
Asia, South
0.5(0.1‐1.9)
1.3(0.2‐4.7)
0.8(0.1‐3.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.2(0.1‐0.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.2(0.1‐0.4)
0.5(0.2‐0.8)
0.7(0.3‐1.2)
1.8(0.7‐4.0)
1.9(1.0‐3.2)
4.0(2.2‐7.1)
5.8(3.2‐9.8)
10.9(5.9‐18.6)
18.1(9.5‐33.2)
39.0(19.2‐76.9)
0.0(0.0‐0.2)
0.1(0.0‐0.2)
0.1(0.0‐0.4)
0.2(0.0‐1.0)
0.4(0.1‐2.0)
1.0(0.1‐4.3)
1.7(0.3‐6.8)
3.3(0.5‐14.2)
6.3(0.9‐25.5)
15.5(2.2‐58.8)
Oceania
3.9(1.4‐7.5)
9.3(3.3‐17.9)
Asia, Southeast
0.3(0.2‐0.4)
0.7(0.5‐1.0)
5.9(2.1‐11.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.3)
0.4(0.3‐0.7)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.3(0.1‐0.6)
0.5(0.1‐1.0)
0.8(0.2‐1.8)
1.9(0.4‐4.2)
3.3(0.9‐7.1)
8.5(2.0‐19.2)
11.4(3.1‐24.4)
25.4(7.4‐53.6)
40.3(12.4‐86.0)
111.9(40.7‐218.3)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
0.3(0.2‐0.7)
0.7(0.4‐1.3)
1.1(0.6‐2.0)
1.8(1.0‐3.1)
3.3(1.6‐5.6)
Asia, East
0.6(0.2‐1.6)
1.4(0.4‐3.8)
0.9(0.3‐2.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
6.4(3.0‐11.8)
0.0(0.0‐0.1)
0.0(0.0‐0.2)
0.1(0.0‐0.2)
0.1(0.0‐0.3)
0.3(0.1‐0.8)
0.8(0.2‐2.8)
1.5(0.4‐4.4)
3.4(0.9‐10.8)
6.3(1.5‐20.0)
20.2(4.3‐74.7)
Latin America, Tropical
Latin America, Central
2.1(1.2‐3.7)
5.0(2.9‐8.8)
3.2(1.9‐5.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.9(0.6‐1.4)
2.2(1.5‐3.3)
1.4(0.9‐2.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
0.4(0.2‐0.8)
0.9(0.3‐1.9)
1.9(0.7‐4.0)
3.8(1.6‐7.9)
6.9(2.8‐13.8)
13.9(6.1‐28.1)
23.2(10.1‐44.5)
59.7(26.1‐112.1)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.2(0.1‐0.4)
0.3(0.2‐0.6)
0.6(0.3‐1.1)
1.3(0.7‐2.2)
2.8(1.6‐4.8)
5.6(3.1‐9.8)
10.3(5.5‐18.1)
Latin America, Andean
0.6(0.4‐1.0)
1.5(0.9‐2.3)
1.0(0.6‐1.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
28.4(16.4‐46.3)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.1(0.1‐0.2)
0.3(0.2‐0.6)
0.5(0.3‐0.9)
0.9(0.4‐1.6)
1.6(0.9‐2.8)
2.9(1.6‐5.0)
6.5(3.3‐11.6)
21.6(11.3‐39.0)
Caribbean
1.2(0.8‐1.7)
2.8(1.8‐4.0)
1.8(1.1‐2.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.3)
0.1(0.1‐0.2)
0.2(0.1‐0.5)
0.3(0.2‐0.5)
0.7(0.4‐1.3)
1.3(0.6‐2.6)
2.3(1.2‐4.8)
3.4(1.8‐6.0)
7.5(4.0‐12.4)
13.1(7.7‐21.4)
32.4(18.9‐53.9)
Developed
2.7(1.9‐4.3)
6.5(4.5‐10.2)
4.1(2.8‐6.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
Developing
0.7(0.4‐1.3)
1.8(0.9‐3.2)
1.1(0.6‐2.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.3(0.2‐0.4)
0.5(0.3‐0.9)
1.2(0.7‐1.9)
2.5(1.6‐4.2)
5.6(3.6‐9.3)
11.8(7.8‐19.1)
27.4(17.5‐43.9)
109.1(71.1‐178.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.3)
0.4(0.2‐0.7)
0.6(0.3‐1.1)
1.3(0.7‐2.7)
2.2(1.1‐4.1)
4.3(2.2‐8.6)
8.0(3.9‐16.9)
Global
1.6(1.0‐2.4)
3.8(2.4‐5.8)
2.4(1.6‐3.7)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
22.5(11.2‐47.7)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.2(0.1‐0.3)
0.4(0.2‐0.7)
0.7(0.4‐1.2)
1.7(1.0‐2.9)
3.2(2.0‐5.4)
7.0(4.3‐11.8)
15.3(9.2‐24.9)
62.6(39.4‐100.7)
Females
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
North America, High Income
2.6(1.4‐4.7)
6.2(3.3‐11.3)
3.9(2.1‐7.2)
Latin America, Southern
1.5(1.1‐2.2)
3.7(2.6‐5.3)
2.4(1.6‐3.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.5)
0.6(0.2‐1.2)
1.3(0.6‐2.8)
3.2(1.6‐6.1)
8.2(4.0‐15.4)
21.3(10.0‐40.2)
123.8(50.8‐267.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.3)
0.4(0.2‐0.7)
0.6(0.3‐1.1)
1.2(0.6‐2.0)
2.6(1.6‐4.1)
7.3(4.2‐11.7)
14.9(8.7‐23.6)
63.8(35.4‐108.2)
Europe, Western
3.7(3.0‐4.6)
8.9(7.1‐11.0)
5.6(4.5‐7.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.3(0.2‐0.4)
0.5(0.4‐0.7)
1.4(1.1‐1.9)
3.8(2.9‐4.8)
10.9(8.2‐14.5)
31.8(24.2‐41.0)
181.5(135.2‐242.1)
Australasia
3.0(1.6‐5.5)
Asia Pacific, High Income
1.5(0.9‐2.4)
7.1(3.8‐13.2)
4.5(2.4‐8.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.0(0.0‐0.0)
0.1(0.1‐0.3)
0.2(0.1‐0.5)
0.5(0.2‐1.1)
1.1(0.5‐2.3)
2.4(1.2‐4.5)
7.7(3.9‐14.6)
22.4(10.9‐44.0)
151.5(63.6‐315.2)
3.5(2.1‐5.8)
2.2(1.3‐3.7)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.3(0.1‐0.5)
0.6(0.3‐1.1)
1.6(0.9‐2.6)
4.4(2.5‐7.1)
10.7(6.1‐17.3)
Europe, Eastern
72.7(34.5‐136.1)
0.4(0.2‐0.6)
0.9(0.5‐1.6)
0.6(0.3‐1.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.2(0.0‐0.7)
0.2(0.0‐0.4)
0.4(0.1‐1.0)
0.7(0.2‐2.0)
1.2(0.4‐2.9)
1.9(0.5‐4.7)
4.4(1.6‐9.9)
11.1(4.3‐25.6)
Europe, Central
1.2(0.9‐1.4)
2.8(2.3‐3.4)
1.8(1.4‐2.2)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.2(0.1‐0.2)
0.3(0.2‐0.4)
0.6(0.4‐0.8)
1.3(0.9‐1.9)
2.6(1.8‐3.6)
6.1(4.4‐8.2)
14.2(10.6‐19.3)
41.6(28.4‐57.2)
Asia, Central
0.1(0.1‐0.1)
0.3(0.2‐0.4)
0.2(0.1‐0.2)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.2(0.1‐0.3)
0.3(0.1‐0.6)
0.5(0.3‐0.9)
0.6(0.3‐1.3)
1.1(0.7‐1.9)
2.4(1.4‐3.9)
Sub‐Saharan Africa, West
0.7(0.3‐1.7)
1.7(0.7‐4.0)
1.1(0.4‐2.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.4)
0.2(0.1‐0.5)
0.5(0.2‐1.2)
1.0(0.4‐2.6)
2.1(0.8‐5.3)
4.4(1.5‐10.7)
8.8(3.1‐21.3)
22.9(6.3‐63.0)
Sub‐Saharan Africa, Southern
1.6(1.1‐2.5)
3.9(2.6‐6.0)
2.5(1.6‐3.8)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.2)
0.1(0.1‐0.3)
0.2(0.1‐0.3)
0.3(0.1‐0.5)
0.3(0.2‐0.7)
0.9(0.4‐1.8)
1.7(0.9‐3.2)
5.3(2.9‐9.4)
8.3(4.4‐14.9)
16.7(8.5‐29.8)
57.2(28.1‐111.0)
Sub‐Saharan Africa, East
0.6(0.2‐1.2)
1.4(0.6‐2.8)
0.9(0.4‐1.8)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.3)
0.1(0.1‐0.3)
0.4(0.1‐0.8)
0.8(0.3‐1.8)
1.8(0.7‐4.2)
3.4(1.3‐7.4)
6.6(2.6‐14.1)
18.5(6.3‐43.7)
Sub‐Saharan Africa, Central
0.6(0.3‐1.4)
1.5(0.6‐3.3)
1.0(0.4‐2.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.0‐0.4)
0.2(0.1‐0.5)
0.4(0.1‐1.2)
1.0(0.2‐3.0)
2.1(0.6‐5.7)
4.2(1.1‐12.6)
7.6(2.5‐20.1)
19.2(5.3‐50.1)
North Africa / Middle East
1.3(1.0‐1.7)
3.1(2.3‐4.0)
2.0(1.5‐2.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.1‐0.3)
0.2(0.1‐0.4)
0.3(0.2‐0.5)
0.8(0.5‐1.6)
0.7(0.4‐1.1)
1.4(0.8‐2.3)
2.7(1.6‐4.6)
4.8(2.9‐7.6)
8.5(5.1‐14.5)
15.9(10.2‐25.2)
27.1(17.0‐41.0)
Asia, South
0.7(0.2‐1.9)
1.8(0.5‐4.5)
1.1(0.3‐2.8)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.0‐0.6)
0.2(0.0‐0.6)
0.4(0.1‐1.6)
1.1(0.2‐3.3)
2.1(0.4‐7.0)
4.8(0.8‐15.9)
8.4(1.7‐23.6)
24.2(5.7‐69.2)
Oceania
3.0(1.2‐6.1)
7.1(3.0‐14.6)
4.5(1.9‐9.3)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.2)
0.1(0.0‐0.3)
0.2(0.0‐0.7)
0.6(0.1‐2.3)
0.8(0.2‐2.4)
1.8(0.4‐6.1)
4.7(1.0‐16.2)
9.1(2.2‐28.2)
18.5(4.6‐57.1)
40.7(12.0‐109.5)
86.0(30.9‐186.8)
Asia, Southeast
0.3(0.2‐0.4)
0.7(0.5‐1.0)
0.5(0.3‐0.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
0.3(0.1‐0.5)
0.4(0.2‐0.8)
0.7(0.3‐1.4)
1.1(0.6‐2.2)
2.1(1.1‐4.2)
3.2(1.9‐5.8)
5.9(3.5‐10.4)
GBD Region
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
1.1(0.4‐2.4)
2.7(1.1‐5.8)
5.6(2.3‐12.1)
1.3(0.7‐2.1)
3.2(1.7‐5.5)
5.7(3.2‐9.5)
1.3(0.8‐2.2)
2.9(1.8‐4.4)
6.6(4.2‐10.1)
0.3(0.1‐0.6)
1.0(0.4‐2.2)
2.0(0.7‐4.4)
0.4(0.2‐0.9)
1.2(0.5‐2.6)
2.5(1.1‐5.6)
0.1(0.1‐0.3)
0.3(0.1‐0.7)
0.6(0.2‐1.7)
0.2(0.1‐0.2)
0.4(0.3‐0.8)
0.8(0.5‐1.3)
0.1(0.0‐0.2)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.0‐0.2)
0.1(0.1‐0.3)
0.2(0.1‐0.5)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
70‐74 years
Asia, East
1.3(0.5‐2.9)
3.2(1.2‐7.0)
2.0(0.7‐4.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.0‐0.6)
0.1(0.0‐0.4)
0.3(0.1‐1.1)
1.1(0.2‐3.5)
2.4(0.4‐7.4)
6.1(1.0‐20.1)
13.3(3.0‐36.6)
55.0(14.1‐142.4)
Latin America, Tropical
1.6(1.1‐2.5)
3.9(2.6‐5.9)
2.5(1.6‐3.8)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.1‐0.3)
0.3(0.1‐0.6)
0.5(0.2‐0.9)
1.0(0.4‐1.9)
1.9(0.9‐3.5)
3.8(2.0‐6.2)
8.7(4.6‐14.4)
16.7(8.4‐29.0)
57.9(26.1‐112.1)
Latin America, Central
0.8(0.6‐1.1)
1.9(1.4‐2.6)
1.2(0.9‐1.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.2(0.1‐0.3)
0.3(0.2‐0.5)
0.5(0.3‐0.8)
1.1(0.7‐1.7)
2.2(1.4‐3.4)
4.2(2.7‐6.6)
8.8(5.6‐13.8)
26.4(14.4‐45.3)
Latin America, Andean
0.7(0.5‐1.0)
1.8(1.3‐2.4)
1.1(0.8‐1.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.2(0.1‐0.4)
0.3(0.2‐0.6)
0.5(0.2‐0.8)
0.9(0.4‐1.7)
1.5(0.8‐2.9)
3.7(1.8‐7.2)
8.9(5.0‐15.6)
25.6(13.8‐42.0)
Caribbean
1.5(1.1‐2.0)
3.6(2.6‐4.9)
2.3(1.7‐3.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.3)
0.2(0.1‐0.4)
0.6(0.3‐1.4)
0.5(0.2‐1.3)
0.6(0.3‐1.3)
1.0(0.5‐2.1)
2.9(1.4‐5.7)
3.3(1.8‐6.6)
9.8(5.2‐18.8)
15.6(9.2‐25.1)
45.7(26.6‐72.9)
Developed
2.4(2.0‐3.0)
5.7(4.7‐7.2)
3.6(3.0‐4.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.2(0.2‐0.3)
0.5(0.4‐0.7)
1.1(0.9‐1.6)
2.8(2.2‐3.6)
7.0(5.4‐8.9)
19.9(15.8‐25.2)
116.3(89.3‐156.7)
Developing
1.0(0.6‐1.7)
2.5(1.5‐4.1)
1.6(1.0‐2.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.2(0.1‐0.4)
0.2(0.2‐0.4)
0.5(0.3‐0.9)
1.2(0.6‐2.2)
2.4(1.3‐4.6)
5.3(2.7‐10.7)
10.7(5.7‐21.0)
37.7(20.1‐74.2)
Global
1.7(1.4‐2.2)
4.2(3.4‐5.4)
2.7(2.2‐3.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.1‐0.1)
0.2(0.1‐0.3)
0.2(0.2‐0.4)
0.5(0.3‐0.8)
1.2(0.8‐1.9)
2.5(1.8‐3.9)
6.0(4.2‐9.2)
14.5(10.8‐20.9)
80.9(62.1‐109.0)
Supplemental Table 4b. Estimated age-standardized mortality rates associated with Atrial Fibrillation with 95% Uncertainty Intervals (per
100,000) for all 21 GBD regions for males and females: 1990.
GBD Region
Males
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
North America, High Income
0.9(0.6‐1.4)
2.3(1.5‐3.4)
1.4(0.9‐2.2)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.2(0.1‐0.3)
0.4(0.2‐0.7)
1.0(0.6‐1.8)
2.1(1.2‐3.6)
4.9(2.9‐7.9)
10.1(5.8‐16.1)
36.2(20.9‐60.0)
Latin America, Southern
1.2(0.7‐1.9)
2.8(1.7‐4.5)
1.8(1.1‐2.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.0‐0.3)
0.2(0.1‐0.4)
0.4(0.2‐0.9)
0.9(0.4‐2.0)
2.1(1.0‐4.2)
3.5(1.7‐7.1)
6.4(3.3‐12.1)
14.1(7.3‐26.9)
36.4(18.3‐69.6)
Europe, Western
1.8(1.2‐2.7)
4.3(3.0‐6.5)
2.8(1.9‐4.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.1‐0.1)
0.2(0.1‐0.3)
0.4(0.3‐0.7)
0.9(0.5‐1.4)
1.9(1.3‐2.9)
4.4(2.9‐6.6)
9.8(6.3‐14.6)
21.2(13.6‐32.7)
65.1(44.5‐98.7)
Australasia
1.6(1.0‐2.3)
3.7(2.5‐5.5)
2.4(1.6‐3.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.2(0.1‐0.3)
0.7(0.3‐1.3)
1.4(0.7‐2.5)
3.4(1.9‐6.0)
8.2(4.6‐13.2)
17.8(10.2‐28.4)
59.8(36.0‐97.4)
Asia Pacific, High Income
1.6(1.0‐2.3)
3.7(2.4‐5.5)
2.4(1.5‐3.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.2(0.1‐0.3)
0.3(0.2‐0.6)
0.8(0.5‐1.4)
1.7(0.9‐2.8)
3.8(2.1‐6.1)
8.5(4.6‐13.5)
18.6(9.8‐31.2)
55.2(30.6‐90.7)
Europe, Eastern
0.2(0.1‐0.4)
0.6(0.3‐1.0)
0.4(0.2‐0.7)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.3)
0.3(0.1‐0.7)
0.6(0.2‐1.4)
0.9(0.4‐1.7)
1.4(0.5‐3.0)
2.7(1.0‐5.7)
6.0(2.3‐12.8)
Europe, Central
1.1(0.7‐1.7)
2.5(1.7‐4.0)
1.6(1.1‐2.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.3(0.1‐0.6)
0.5(0.3‐1.0)
1.0(0.5‐1.8)
2.1(1.1‐3.8)
3.8(2.1‐6.7)
6.8(3.7‐12.2)
12.7(6.9‐22.0)
27.7(15.5‐48.4)
Asia, Central
0.2(0.1‐0.3)
0.4(0.3‐0.6)
0.3(0.2‐0.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.3(0.1‐0.6)
0.3(0.2‐0.7)
0.6(0.3‐1.3)
0.6(0.3‐1.1)
1.1(0.6‐2.0)
1.5(0.8‐2.6)
3.3(1.9‐6.0)
Sub‐Saharan Africa, West
0.2(0.0‐0.6)
0.5(0.1‐1.5)
0.3(0.1‐1.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.3)
0.2(0.0‐0.6)
0.4(0.1‐1.4)
0.7(0.2‐2.3)
1.3(0.3‐3.9)
2.4(0.5‐8.3)
5.3(1.1‐18.4)
Sub‐Saharan Africa, Southern
0.9(0.4‐1.7)
2.3(1.0‐4.2)
1.5(0.6‐2.7)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.0‐0.4)
0.2(0.1‐0.7)
0.4(0.1‐1.0)
0.9(0.3‐2.6)
1.7(0.6‐4.1)
2.9(1.1‐7.0)
5.6(2.0‐12.8)
11.3(4.3‐26.1)
27.8(11.3‐64.3)
Sub‐Saharan Africa, East
0.3(0.1‐1.0)
0.7(0.2‐2.3)
0.5(0.1‐1.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.3)
0.2(0.0‐0.5)
0.3(0.1‐1.0)
0.7(0.2‐2.1)
1.1(0.3‐3.6)
2.0(0.5‐6.4)
3.4(0.8‐11.2)
7.3(1.5‐26.9)
Sub‐Saharan Africa, Central
0.3(0.1‐0.9)
0.6(0.1‐2.1)
0.4(0.1‐1.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.0‐0.5)
0.3(0.1‐1.0)
0.6(0.1‐2.2)
0.9(0.2‐3.1)
1.8(0.4‐5.4)
3.0(0.6‐10.2)
6.3(1.2‐26.6)
North Africa / Middle East
1.3(0.6‐2.7)
3.0(1.3‐6.4)
1.9(0.9‐4.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.2(0.0‐0.5)
0.2(0.1‐0.5)
0.4(0.1‐1.0)
0.6(0.2‐1.4)
1.7(0.4‐5.1)
1.5(0.5‐4.0)
3.2(1.2‐9.3)
4.5(1.8‐11.9)
8.7(3.2‐21.4)
12.9(5.2‐30.7)
24.5(10.0‐57.7)
Asia, South
0.3(0.1‐0.9)
0.7(0.1‐2.1)
0.4(0.1‐1.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.0‐0.5)
0.3(0.0‐1.2)
0.6(0.1‐2.2)
0.9(0.2‐3.4)
1.8(0.4‐6.7)
3.1(0.6‐11.8)
7.4(1.3‐27.4)
Oceania
0.9(0.2‐1.8)
2.1(0.6‐4.4)
1.3(0.4‐2.8)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.0‐0.3)
0.2(0.0‐0.5)
0.5(0.1‐1.1)
0.8(0.2‐1.8)
2.1(0.4‐5.1)
2.9(0.7‐6.6)
6.1(1.4‐14.6)
9.1(2.1‐20.2)
22.7(6.7‐49.2)
Asia, Southeast
0.1(0.1‐0.4)
0.4(0.2‐0.9)
0.2(0.1‐0.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
0.4(0.1‐0.9)
0.5(0.2‐1.3)
0.9(0.4‐2.5)
1.8(0.8‐4.5)
3.2(1.0‐9.7)
Asia, East
0.3(0.1‐0.7)
0.7(0.2‐1.7)
0.5(0.2‐1.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.0‐0.2)
0.2(0.0‐0.6)
0.5(0.1‐1.7)
0.9(0.3‐2.5)
1.8(0.5‐4.7)
3.4(0.9‐10.5)
9.3(2.3‐30.6)
Latin America, Tropical
0.8(0.5‐1.2)
2.0(1.3‐2.8)
1.3(0.8‐1.8)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
0.4(0.2‐0.8)
0.8(0.4‐1.5)
1.7(0.8‐2.7)
3.1(1.6‐5.1)
5.8(2.9‐9.7)
9.6(5.2‐16.1)
20.9(11.4‐33.7)
Latin America, Central
0.4(0.3‐0.6)
1.0(0.7‐1.4)
0.7(0.4‐0.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.2(0.1‐0.3)
0.3(0.2‐0.6)
0.7(0.4‐1.1)
1.4(0.8‐2.1)
2.7(1.5‐4.1)
5.0(2.8‐7.6)
12.4(7.5‐19.3)
Latin America, Andean
0.5(0.3‐0.9)
1.1(0.6‐2.0)
0.7(0.4‐1.3)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.0‐0.2)
0.1(0.1‐0.3)
0.3(0.1‐0.6)
0.5(0.2‐1.0)
0.7(0.3‐1.7)
1.4(0.7‐3.1)
2.4(1.1‐5.1)
5.0(2.3‐11.4)
14.3(6.4‐28.7)
Caribbean
0.7(0.4‐1.0)
1.6(0.9‐2.4)
1.0(0.6‐1.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.2)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
0.2(0.1‐0.3)
0.4(0.2‐0.9)
0.8(0.4‐1.6)
1.5(0.7‐3.2)
2.1(1.1‐3.7)
4.3(2.3‐7.5)
8.2(4.4‐14.7)
15.9(8.8‐29.0)
Developed
1.3(0.9‐1.9)
3.1(2.2‐4.6)
2.0(1.4‐2.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.3(0.2‐0.5)
0.7(0.4‐1.0)
1.4(1.0‐2.2)
3.2(2.2‐4.9)
7.0(4.7‐10.3)
15.1(9.9‐22.4)
47.3(31.6‐71.8)
Developing
0.4(0.2‐0.8)
0.9(0.4‐1.8)
0.6(0.3‐1.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.5)
0.4(0.2‐0.8)
0.8(0.3‐1.8)
1.3(0.6‐2.7)
2.4(1.0‐5.1)
4.3(1.9‐9.8)
10.4(4.4‐23.1)
Global
0.8(0.5‐1.1)
1.9(1.3‐2.8)
1.2(0.8‐1.8)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.3(0.1‐0.5)
0.5(0.3‐0.8)
1.0(0.6‐1.8)
2.0(1.2‐3.2)
4.0(2.4‐6.5)
9.0(5.5‐13.6)
28.4(18.6‐42.6)
GBD Region
Females
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
North America, High Income
1.0(0.7‐1.3)
2.3(1.7‐3.2)
1.5(1.1‐2.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.1‐0.2)
0.2(0.1‐0.4)
0.6(0.4‐0.9)
1.5(1.1‐2.2)
3.6(2.4‐5.0)
9.2(6.2‐13.2)
42.8(27.0‐66.0)
Latin America, Southern
1.0(0.7‐1.7)
2.5(1.6‐4.0)
1.6(1.0‐2.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.1‐0.3)
0.2(0.1‐0.5)
0.5(0.2‐1.0)
1.1(0.5‐2.2)
2.1(1.0‐3.8)
4.8(2.5‐8.7)
11.8(6.2‐21.5)
39.4(18.1‐76.1)
Europe, Western
1.6(1.4‐2.0)
3.9(3.3‐4.9)
2.5(2.1‐3.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.1‐0.1)
0.2(0.1‐0.3)
0.4(0.3‐0.6)
1.1(0.9‐1.4)
2.7(2.2‐3.3)
7.1(5.8‐8.8)
17.9(14.7‐22.3)
69.4(53.9‐92.2)
Australasia
1.6(1.2‐2.3)
3.9(2.8‐5.5)
2.5(1.8‐3.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.3(0.2‐0.5)
0.8(0.5‐1.3)
2.1(1.4‐3.2)
6.7(4.5‐9.5)
16.0(10.4‐24.0)
73.8(45.8‐113.5)
Asia Pacific, High Income
1.1(0.8‐1.6)
2.7(2.0‐3.8)
1.7(1.3‐2.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.2)
0.4(0.2‐0.6)
0.9(0.6‐1.3)
2.1(1.4‐3.0)
4.9(3.3‐7.0)
12.5(8.0‐18.4)
47.2(28.0‐75.5)
Europe, Eastern
0.2(0.1‐0.3)
0.5(0.2‐0.8)
0.3(0.2‐0.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.3)
0.1(0.0‐0.2)
0.2(0.1‐0.5)
0.4(0.1‐1.1)
0.6(0.2‐1.4)
1.0(0.3‐2.5)
2.3(0.8‐4.8)
5.5(2.1‐13.0)
Europe, Central
0.6(0.4‐0.9)
1.4(1.0‐2.1)
0.9(0.6‐1.3)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.3)
0.4(0.2‐0.8)
0.8(0.5‐1.5)
1.6(0.9‐3.0)
3.3(2.0‐6.1)
7.0(4.1‐12.7)
18.4(9.3‐37.7)
Asia, Central
0.1(0.1‐0.1)
0.2(0.2‐0.3)
0.1(0.1‐0.2)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.2(0.1‐0.3)
0.3(0.1‐0.5)
0.4(0.2‐0.8)
0.6(0.3‐1.1)
1.1(0.5‐2.1)
2.1(1.2‐4.1)
Sub‐Saharan Africa, West
0.6(0.2‐1.4)
1.3(0.4‐3.4)
0.8(0.3‐2.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.3)
0.2(0.1‐0.5)
0.4(0.1‐1.0)
0.9(0.2‐2.4)
1.6(0.5‐4.2)
3.4(0.9‐9.0)
6.8(2.1‐17.3)
16.8(3.9‐51.4)
Sub‐Saharan Africa, Southern
1.4(0.9‐2.3)
3.5(2.1‐5.6)
2.2(1.3‐3.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.0‐0.4)
0.2(0.0‐0.5)
0.3(0.1‐0.7)
0.4(0.1‐1.0)
1.0(0.4‐2.3)
1.6(0.6‐3.5)
3.8(1.7‐7.7)
8.5(3.7‐16.8)
15.8(7.1‐31.3)
49.0(19.5‐105.4)
Sub‐Saharan Africa, East
0.5(0.2‐1.2)
1.2(0.5‐2.8)
0.8(0.3‐1.8)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.3)
0.1(0.0‐0.4)
0.3(0.1‐0.8)
0.8(0.2‐2.1)
1.6(0.5‐4.3)
3.3(1.1‐8.4)
6.1(2.1‐14.3)
15.6(4.2‐41.9)
Sub‐Saharan Africa, Central
0.5(0.2‐1.2)
1.1(0.4‐2.9)
0.7(0.2‐1.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.3)
0.1(0.0‐0.5)
0.3(0.1‐1.0)
0.8(0.2‐2.5)
1.6(0.4‐4.9)
2.9(0.7‐8.9)
5.7(1.5‐16.3)
14.1(3.2‐45.5)
North Africa / Middle East
1.0(0.6‐1.7)
2.5(1.5‐4.0)
1.6(1.0‐2.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.1‐0.3)
0.2(0.1‐0.4)
0.3(0.1‐0.7)
0.7(0.3‐1.6)
0.6(0.3‐1.2)
1.1(0.5‐2.4)
2.3(1.0‐4.9)
4.1(2.0‐7.3)
7.4(3.5‐16.0)
13.4(6.5‐26.5)
19.3(9.8‐35.4)
Asia, South
0.5(0.2‐1.3)
1.2(0.4‐3.2)
0.8(0.2‐2.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.0(0.0‐0.2)
0.1(0.0‐0.4)
0.2(0.0‐0.6)
0.3(0.0‐1.2)
0.9(0.1‐3.4)
1.5(0.2‐5.5)
3.4(0.6‐12.1)
6.2(1.2‐21.5)
15.8(3.9‐45.8)
Oceania
0.5(0.2‐1.0)
1.2(0.5‐2.5)
0.8(0.3‐1.6)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.4)
0.2(0.0‐0.5)
0.4(0.1‐1.2)
1.0(0.2‐3.2)
1.9(0.4‐5.9)
3.4(0.8‐9.9)
6.8(2.0‐18.7)
13.3(5.1‐28.5)
Asia, Southeast
0.1(0.1‐0.2)
0.3(0.2‐0.6)
0.2(0.1‐0.4)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.3)
0.2(0.1‐0.5)
0.3(0.1‐0.8)
0.6(0.2‐1.3)
1.1(0.4‐2.4)
1.5(0.7‐3.1)
2.6(1.2‐5.2)
Asia, East
0.9(0.3‐2.1)
2.1(0.6‐5.1)
1.4(0.4‐3.2)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.1(0.0‐0.5)
0.1(0.0‐0.4)
0.3(0.0‐1.1)
0.9(0.1‐3.5)
2.0(0.3‐7.2)
4.6(0.6‐16.4)
9.4(1.5‐28.5)
34.2(8.4‐98.1)
Latin America, Tropical
0.9(0.7‐1.1)
2.1(1.7‐2.7)
1.4(1.1‐1.7)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
0.4(0.2‐0.6)
0.7(0.4‐1.2)
1.4(0.8‐2.1)
2.9(1.9‐4.3)
5.6(3.7‐8.3)
10.4(6.9‐15.1)
26.2(15.6‐40.9)
Latin America, Central
0.5(0.4‐0.6)
1.2(1.0‐1.4)
0.7(0.6‐0.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.1‐0.1)
0.1(0.1‐0.2)
0.2(0.2‐0.4)
0.5(0.3‐0.7)
0.9(0.6‐1.3)
1.6(1.1‐2.1)
2.8(2.1‐3.7)
5.5(3.9‐7.4)
14.0(9.3‐20.0)
Latin America, Andean
0.6(0.4‐1.0)
1.4(0.9‐2.3)
0.9(0.6‐1.5)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.0‐0.4)
0.3(0.1‐0.6)
0.4(0.1‐0.9)
0.8(0.3‐2.1)
1.4(0.5‐3.3)
3.2(1.2‐7.4)
6.7(2.9‐13.9)
19.4(9.1‐39.4)
Caribbean
0.9(0.7‐1.3)
2.2(1.6‐3.1)
1.4(1.0‐2.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.0‐0.2)
0.1(0.1‐0.3)
0.5(0.2‐1.1)
0.4(0.1‐1.0)
0.4(0.2‐1.0)
0.7(0.3‐1.5)
1.9(0.9‐4.3)
2.2(1.1‐4.5)
6.1(3.1‐11.9)
10.4(6.2‐16.9)
23.3(13.5‐39.4)
Developed
1.1(1.0‐1.3)
2.6(2.3‐3.1)
1.7(1.5‐1.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.1(0.1‐0.1)
0.1(0.1‐0.2)
0.3(0.3‐0.4)
0.8(0.6‐1.0)
1.8(1.6‐2.2)
4.5(3.9‐5.3)
11.4(9.8‐13.4)
46.9(38.6‐57.9)
Developing
0.7(0.4‐1.4)
1.7(0.9‐3.3)
1.1(0.6‐2.1)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.2)
0.2(0.1‐0.4)
0.2(0.1‐0.4)
0.4(0.2‐0.8)
0.9(0.4‐2.3)
1.8(0.8‐4.1)
4.0(1.7‐9.6)
7.7(3.5‐16.8)
23.9(11.1‐53.6)
Global
0.9(0.7‐1.2)
2.2(1.8‐3.0)
1.4(1.1‐1.9)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.0)
0.0(0.0‐0.1)
0.1(0.0‐0.1)
0.1(0.1‐0.3)
0.2(0.1‐0.3)
0.4(0.2‐0.7)
0.9(0.5‐1.7)
1.8(1.2‐3.1)
4.2(2.8‐7.6)
9.6(7.3‐14.0)
37.6(29.9‐51.0)
Supplemental Table 5a. Estimated age-standardized DALYs associated with Atrial Fibrillation with 95% Uncertainty Intervals (per
100,000) for all 21 GBD regions for males and females: 2010
GBD Region
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
North America, High Income
102.9(74.3‐142.5) 239.8(173.5‐332.0) 155.6(112.5‐215.3)
0.4(0.0‐1.4)
2.9(0.9‐6.1)
4.6(2.0‐8.9)
5.2(2.3‐9.1)
5.8(2.6‐10.0)
7.3(3.6‐12.4)
11.7(6.8‐18.1)
17.4(10.4‐26.9)
31.4(19.8‐47.7)
58.2(37.3‐83.4)
97.2(63.2‐142.8)
162.9(108.8‐233.6) 277.6(184.8‐396.3) 452.1(309.5‐634.3) 715.1(478.6‐1,033.3)
Latin America, Southern
88.7(52.6‐160.4)
206.1(122.6‐370.4)
134.1(79.6‐242.2)
0.4(0.0‐1.4)
2.6(0.6‐6.3)
4.3(1.4‐9.3)
5.0(1.8‐11.0)
5.5(1.8‐12.2)
6.8(2.5‐15.2)
11.3(5.2‐22.2)
18.2(9.4‐33.4)
31.4(16.1‐61.8)
55.3(28.6‐107.5)
91.1(47.6‐171.7)
155.4(84.4‐294.6)
267.0(152.1‐466.1) 405.5(223.9‐714.3) 592.6(337.2‐1,069.5)
863.4(510.8‐1,510.9)
1,256.6(752.6‐2,190.3)
Europe, Western
83.8(62.1‐109.3)
196.1(145.6‐256.2)
126.9(94.1‐165.7)
0.3(0.1‐0.6)
2.1(1.1‐3.5)
3.4(2.0‐5.4)
3.9(2.3‐6.2)
4.1(2.4‐6.3)
5.0(3.0‐7.6)
8.5(5.6‐12.0)
12.6(8.5‐17.6)
22.5(15.6‐31.4)
40.9(28.7‐55.8)
70.3(48.7‐96.3)
124.1(87.8‐168.8)
212.7(155.1‐286.1) 357.9(258.6‐474.7)
572.2(414.7‐778.3)
896.9(646.4‐1,212.1)
1,493.9(1,061.5‐2,029.3)
Australasia
91.6(66.3‐125.7)
213.3(154.0‐292.6) 138.6(100.0‐190.2)
0.4(0.0‐1.2)
2.6(0.9‐5.2)
4.2(1.7‐7.5)
4.9(2.1‐8.8)
5.4(2.4‐10.0)
6.6(3.2‐11.5)
11.2(6.3‐17.5)
15.8(9.4‐24.2)
25.5(15.8‐37.8)
48.0(31.0‐71.7)
76.8(48.7‐114.1)
140.1(91.6‐202.9)
224.8(142.6‐326.4) 372.3(253.1‐537.8)
589.4(394.4‐862.3)
928.7(607.7‐1,390.9)
1,725.7(1,084.8‐2,621.8)
Asia Pacific, High Income
54.9(38.1‐80.8)
128.9(89.5‐190.4)
83.3(57.8‐122.6)
0.1(0.0‐0.7)
1.1(0.2‐2.5)
1.8(0.6‐3.4)
2.1(0.8‐4.0)
2.3(0.9‐4.3)
2.9(1.3‐5.2)
5.3(3.0‐8.1)
7.8(4.7‐12.0)
14.9(9.4‐22.6)
27.6(18.2‐41.0)
47.9(31.3‐70.7)
90.4(59.2‐136.2)
152.5(97.2‐234.8)
246.1(163.1‐381.4)
373.1(234.4‐621.7)
541.1(329.0‐936.3)
947.7(564.6‐1,514.1)
Europe, Eastern
58.9(31.1‐104.1)
134.6(71.9‐238.4)
88.4(46.9‐156.4)
0.4(0.0‐1.2)
2.7(0.7‐6.0)
4.5(1.5‐9.7)
5.1(1.8‐11.0)
5.6(2.0‐11.5)
6.6(2.4‐13.5)
10.2(4.9‐19.6)
14.3(6.7‐27.9)
25.2(12.4‐45.9)
42.6(21.7‐78.1)
69.4(34.4‐130.7)
114.4(58.8‐205.3)
177.8(90.6‐322.0)
261.8(143.0‐461.0)
364.0(186.1‐663.8)
501.9(261.1‐911.2)
781.7(411.1‐1,462.5)
Europe, Central
85.5(58.6‐125.4)
198.3(136.8‐289.9)
129.1(88.7‐189.1)
0.4(0.1‐0.9)
2.7(1.1‐5.1)
4.5(2.2‐8.2)
5.2(2.6‐9.6)
5.6(2.8‐10.4)
6.9(3.6‐12.4)
10.8(6.5‐18.1)
17.8(11.1‐27.8)
30.9(19.7‐47.8)
60.0(39.8‐92.5)
98.0(63.6‐152.3)
159.4(102.4‐241.7) 256.7(169.0‐385.1) 392.0(255.9‐588.4)
560.8(358.6‐842.4)
802.6(531.2‐1,213.0)
1,149.5(770.9‐1,732.1)
Asia, Central
57.2(34.0‐91.2)
130.0(77.2‐208.2)
85.7(50.9‐137.0)
0.4(0.0‐0.9)
2.7(1.1‐5.5)
4.7(2.1‐8.7)
5.5(2.5‐10.0)
5.9(2.7‐11.0)
6.9(3.4‐12.3)
11.8(6.9‐19.2)
18.1(9.9‐29.8)
26.1(15.0‐43.0)
46.5(26.6‐76.1)
81.6(47.5‐130.9)
120.0(69.8‐193.7)
179.2(105.7‐294.0) 244.7(136.1‐397.1)
340.3(194.7‐559.0)
443.3(252.0‐730.0)
680.0(390.3‐1,080.4)
Sub‐Saharan Africa, West
54.1(31.5‐89.5)
123.9(72.2‐206.0)
81.3(47.4‐135.0)
0.3(0.1‐0.9)
2.4(1.0‐5.1)
4.1(1.8‐7.6)
4.8(2.3‐9.2)
5.2(2.5‐9.6)
6.1(3.0‐11.2)
8.9(4.8‐15.7)
12.6(7.1‐21.4)
21.0(12.1‐35.9)
35.9(20.2‐62.0)
60.1(33.7‐105.0)
99.1(56.6‐171.8)
159.4(89.3‐275.7)
346.8(196.2‐593.2)
484.1(275.0‐819.7)
753.6(424.2‐1,252.7)
Sub‐Saharan Africa, Southern
91.8(52.9‐154.6)
212.8(122.5‐358.8)
138.7(79.9‐233.7)
0.4(0.0‐1.1)
2.8(0.8‐6.4)
4.7(1.6‐10.0)
5.5(2.1‐11.3)
5.9(2.1‐12.1)
7.1(2.6‐14.9)
14.4(7.5‐25.5)
21.0(10.3‐38.3)
33.7(16.7‐60.2)
57.4(27.5‐106.6)
99.1(48.7‐186.0)
171.4(88.7‐311.2)
271.6(143.1‐499.6) 406.5(219.4‐716.6) 592.0(324.6‐1,022.6)
854.1(459.0‐1,465.0)
1,327.4(760.7‐2,262.6)
Sub‐Saharan Africa, East
54.3(33.2‐83.9)
124.0(75.5‐191.9)
81.4(49.7‐125.5)
0.3(0.1‐0.8)
2.6(1.2‐4.8)
4.3(2.2‐7.6)
5.0(2.7‐8.6)
5.4(2.9‐8.9)
6.2(3.4‐10.2)
8.9(5.4‐14.2)
12.7(7.7‐19.7)
21.1(12.5‐33.2)
37.0(22.3‐58.4)
61.4(36.3‐98.7)
100.3(60.9‐156.0)
160.7(95.6‐256.2)
240.3(144.2‐375.4)
347.9(207.1‐552.4)
477.7(285.9‐760.8)
740.9(443.3‐1,135.6)
Sub‐Saharan Africa, Central
56.1(28.5‐101.6)
128.5(65.1‐230.8)
84.3(42.7‐152.2)
0.3(0.0‐1.1)
2.5(0.7‐5.5)
4.2(1.4‐9.4)
4.9(1.7‐10.8)
5.4(1.8‐12.1)
6.3(2.4‐13.1)
9.0(4.0‐17.8)
12.8(5.8‐25.1)
21.6(9.9‐40.5)
37.5(17.9‐69.3)
62.9(29.3‐120.3)
103.6(49.3‐192.8)
166.9(78.1‐312.0)
247.9(120.3‐457.2)
361.8(177.0‐674.1)
496.5(246.2‐912.9)
773.6(395.8‐1,400.1)
North Africa / Middle East
81.4(56.9‐113.1)
187.9(131.9‐261.4)
123.1(86.2‐171.0)
0.3(0.1‐0.7)
2.3(1.2‐4.1)
3.8(2.1‐6.3)
4.4(2.5‐7.1)
4.8(2.8‐8.0)
5.8(3.3‐9.4)
18.8(10.3‐35.3)
22.4(15.2‐31.7)
40.5(26.3‐60.9)
63.9(41.6‐92.6)
121.1(69.6‐204.9) 151.2(100.0‐220.1) 251.7(167.6‐369.5) 353.1(236.9‐513.4)
520.7(353.1‐750.9)
698.2(471.9‐1,012.2)
976.5(657.0‐1,422.1)
Asia, South
50.0(31.4‐77.2)
115.2(72.5‐180.0)
75.3(47.4‐117.0)
0.3(0.0‐0.9)
2.0(0.7‐4.0)
3.2(1.4‐5.9)
3.7(1.6‐6.7)
4.1(1.9‐7.1)
4.9(2.4‐8.2)
7.5(4.1‐12.0)
11.1(6.3‐18.2)
19.0(11.2‐29.5)
33.2(20.3‐51.7)
323.9(199.6‐523.1)
452.2(277.4‐729.6)
702.5(428.6‐1,110.0)
108.0(59.0‐171.7) 251.5(136.7‐402.2)
163.5(89.0‐261.3)
0.4(0.0‐1.3)
2.8(0.7‐6.4)
4.7(1.6‐10.4)
5.4(1.8‐11.9)
5.4(2.0‐11.4)
6.5(2.4‐14.0)
16.6(8.1‐30.9)
25.3(11.6‐46.9)
45.2(21.7‐79.8)
74.5(36.7‐130.5) 133.5(62.1‐238.0) 208.0(104.3‐371.5) 384.3(187.8‐694.8) 480.7(241.2‐815.7) 745.8(362.0‐1,328.7)
906.9(453.8‐1,534.6)
1,321.5(695.1‐2,201.1)
660.5(381.8‐1,121.8)
Oceania
Males
35+ years
20+ years
56.1(33.7‐90.1)
55‐59 years
91.2(56.4‐150.1)
60‐64 years
148.1(89.9‐251.5)
65‐69 years
238.0(133.9‐417.7)
222.3(135.9‐354.9)
70‐74 years
75‐79 years
80+ years
1,037.0(701.5‐1,505.3)
1,660.0(1,086.8‐2,589.9)
Asia, Southeast
49.3(29.3‐80.7)
113.1(67.1‐184.8)
74.2(43.9‐121.3)
0.3(0.0‐0.8)
2.1(0.9‐4.2)
3.6(1.7‐6.7)
4.1(1.9‐7.5)
4.5(2.1‐8.5)
5.4(2.7‐9.9)
8.2(4.6‐13.9)
12.0(6.8‐20.7)
20.8(11.8‐34.9)
35.5(20.2‐59.3)
58.7(33.3‐95.2)
93.8(54.2‐153.2)
147.2(86.9‐243.9)
218.8(127.2‐359.9)
310.3(176.9‐519.0)
426.3(244.2‐717.3)
Asia, East
44.9(30.5‐63.1)
103.5(70.2‐145.9)
67.7(46.0‐95.2)
0.3(0.0‐1.1)
1.8(0.4‐4.1)
2.9(0.9‐5.8)
3.3(1.1‐6.7)
3.6(1.3‐7.2)
4.4(1.9‐8.0)
6.8(3.2‐11.6)
10.2(5.7‐16.4)
16.9(9.9‐27.2)
29.1(17.9‐44.1)
46.4(30.2‐68.5)
76.1(49.5‐111.9)
126.2(81.6‐193.7)
193.7(128.0‐283.6)
294.9(188.3‐445.8)
413.7(270.5‐648.0)
681.6(437.2‐1,131.4)
Latin America, Tropical
83.5(59.8‐113.2)
194.2(138.9‐264.5)
126.3(90.6‐171.6)
0.3(0.0‐1.2)
2.3(0.6‐5.2)
3.8(1.5‐7.6)
4.4(1.8‐8.5)
4.8(2.1‐8.9)
5.9(2.6‐10.2)
11.1(6.5‐17.4)
16.9(9.9‐25.7)
28.4(17.8‐43.3)
51.6(33.3‐75.2)
90.5(56.6‐132.5)
153.1(101.4‐228.0) 250.6(163.3‐361.9) 380.9(252.1‐564.4)
582.0(385.5‐860.3)
788.2(536.5‐1,133.8)
1,150.7(806.0‐1,583.3)
Latin America, Central
67.3(38.9‐108.7)
154.6(89.7‐250.3)
101.2(58.5‐163.9)
0.4(0.0‐1.0)
2.6(1.0‐5.6)
4.4(2.0‐8.6)
5.2(2.3‐9.9)
5.6(2.5‐10.6)
6.6(3.0‐12.8)
11.3(6.4‐19.3)
15.5(8.6‐27.1)
26.7(14.6‐44.3)
45.3(24.8‐77.0)
72.2(38.6‐123.5)
118.6(65.6‐197.2)
188.5(104.7‐316.3) 298.3(169.9‐489.9)
442.8(257.9‐721.8)
615.7(360.0‐1,022.2)
958.9(555.3‐1,641.3)
Latin America, Andean
67.0(34.6‐123.9)
153.8(79.5‐283.8)
100.7(52.1‐186.7)
0.4(0.0‐1.0)
2.8(0.8‐6.1)
4.5(1.8‐9.2)
5.2(2.0‐10.5)
5.7(2.4‐11.5)
6.8(2.8‐13.9)
11.0(5.6‐20.9)
16.6(8.7‐29.9)
27.0(14.7‐49.6)
44.7(22.5‐84.9)
76.2(39.1‐144.4)
121.5(62.9‐225.4)
189.2(98.4‐351.6)
420.6(211.0‐777.0)
600.8(309.1‐1,102.8)
973.6(491.3‐1,777.1)
Caribbean
83.6(51.5‐132.0)
192.3(118.8‐304.8)
126.1(77.7‐199.1)
0.4(0.0‐1.0)
3.0(1.2‐5.8)
4.8(2.2‐9.1)
5.7(2.7‐10.6)
6.1(3.1‐11.1)
7.4(3.6‐13.4)
17.5(9.5‐30.6)
20.6(12.2‐33.8)
38.3(23.1‐62.0)
58.4(34.9‐96.4)
102.8(60.3‐165.2)
165.6(97.6‐273.4)
259.4(152.8‐428.0) 376.2(221.4‐626.3)
556.2(338.0‐923.0)
746.3(449.6‐1,218.9)
994.3(591.8‐1,703.9)
Developed
81.5(60.8‐106.2)
189.9(142.2‐247.9)
123.3(92.1‐160.5)
0.3(0.1‐0.7)
2.4(1.3‐3.8)
3.8(2.4‐6.0)
4.4(2.7‐6.6)
4.8(2.9‐7.3)
5.9(3.7‐8.9)
9.4(6.4‐13.6)
13.9(9.5‐19.5)
24.9(17.4‐34.1)
45.8(32.5‐62.3)
77.3(54.4‐105.0)
131.8(96.7‐174.2)
218.9(158.3‐293.9) 354.4(256.9‐464.7)
537.2(395.6‐730.6)
814.4(605.4‐1,084.7)
1,365.2(1,008.9‐1,841.8)
Developing
54.5(37.7‐73.2)
125.2(87.0‐168.3)
82.0(56.8‐110.2)
0.3(0.1‐0.6)
2.2(1.3‐3.3)
3.6(2.2‐5.3)
4.1(2.5‐6.3)
4.4(2.8‐6.7)
5.3(3.3‐8.0)
9.2(6.2‐13.1)
12.8(8.8‐17.8)
21.4(14.8‐29.7)
36.9(25.6‐50.2)
62.0(42.7‐86.0)
96.4(67.1‐132.5)
158.1(109.3‐217.8) 237.8(163.8‐325.6)
351.8(243.7‐476.5)
489.5(337.8‐679.6)
774.3(529.9‐1,074.0)
Global
64.5(46.8‐84.2)
149.3(108.7‐194.5)
97.3(70.7‐127.0)
0.3(0.1‐0.6)
2.2(1.3‐3.3)
3.6(2.3‐5.3)
4.1(2.6‐6.2)
4.5(2.9‐6.7)
5.4(3.4‐8.0)
9.3(6.3‐12.8)
13.0(9.0‐17.8)
22.1(15.5‐30.3)
39.0(27.6‐53.2)
65.9(46.2‐89.5)
105.7(75.1‐142.3)
176.9(125.9‐237.6) 274.3(197.2‐362.6)
416.7(301.5‐555.2)
611.9(446.2‐797.6)
1,048.2(765.0‐1,376.7)
GBD Region
60‐64 years
289.7(148.1‐532.4)
Females
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
70‐74 years
75‐79 years
80+ years
North America, High Income
63.0(46.6‐82.6)
146.9(108.8‐192.4)
95.3(70.5‐124.5)
0.2(0.0‐1.0)
1.8(0.5‐3.7)
2.9(0.9‐5.6)
3.3(1.3‐6.3)
3.5(1.4‐6.4)
4.3(1.8‐7.9)
6.8(3.6‐11.2)
10.2(5.8‐16.1)
18.1(11.4‐28.0)
32.0(20.7‐48.5)
52.7(34.6‐75.7)
90.9(60.7‐132.5)
152.8(101.7‐217.8) 255.1(175.2‐359.0)
65‐69 years
414.3(282.8‐576.5)
655.7(442.6‐933.4)
1,189.9(722.0‐1,955.9)
Latin America, Southern
52.1(32.1‐87.5)
121.0(75.5‐202.6)
78.7(48.7‐132.0)
0.2(0.0‐0.9)
1.6(0.3‐3.9)
2.6(0.7‐6.1)
3.0(1.0‐6.7)
3.3(1.0‐7.1)
4.0(1.4‐8.8)
6.4(2.8‐12.6)
10.4(5.1‐19.5)
18.4(9.3‐34.0)
31.9(16.6‐57.3)
54.0(29.1‐90.7)
87.2(46.2‐155.0)
137.9(72.8‐248.3)
220.1(123.0‐385.6)
360.7(209.2‐608.1)
512.5(315.9‐832.6)
808.1(486.4‐1,321.9)
Europe, Western
59.5(48.9‐73.2)
139.5(115.1‐171.5)
90.1(74.2‐110.9)
0.2(0.0‐0.4)
1.4(0.7‐2.3)
2.2(1.3‐3.6)
2.5(1.4‐4.2)
2.6(1.5‐4.1)
3.1(1.8‐4.7)
5.0(3.4‐7.0)
7.6(5.1‐10.9)
13.3(9.0‐18.6)
22.5(15.8‐31.5)
37.9(26.5‐52.4)
65.1(46.5‐88.6)
115.8(83.7‐153.2)
206.7(158.2‐264.8)
370.4(284.3‐471.9)
682.3(548.6‐850.9)
1,412.1(1,106.1‐1,795.9)
Australasia
58.2(42.1‐78.4)
135.8(98.4‐182.9)
88.1(63.9‐118.8)
0.2(0.0‐1.0)
1.6(0.3‐3.5)
2.6(1.0‐4.9)
3.0(1.1‐5.9)
3.2(1.2‐6.2)
3.9(1.6‐7.2)
6.6(3.4‐11.0)
10.1(5.8‐16.3)
14.7(8.5‐23.4)
29.8(18.9‐44.4)
47.7(30.5‐71.6)
81.9(54.2‐120.3)
132.8(86.4‐194.0)
210.2(147.2‐296.2)
352.8(235.2‐512.6)
585.8(380.5‐863.8)
1,249.4(716.0‐2,140.6)
Asia Pacific, High Income
27.3(20.8‐35.4)
63.9(48.4‐82.6)
41.4(31.4‐53.4)
0.1(0.0‐0.5)
0.7(0.0‐1.8)
1.1(0.3‐2.3)
1.3(0.3‐2.5)
1.4(0.4‐3.0)
1.7(0.6‐3.3)
2.9(1.4‐5.0)
4.2(2.2‐7.1)
7.3(4.5‐11.1)
13.2(8.5‐19.3)
22.7(14.5‐33.1)
39.5(26.5‐55.7)
64.8(44.5‐89.9)
104.9(73.9‐144.1)
170.7(120.1‐232.5)
265.3(183.1‐373.8)
574.3(356.1‐894.7)
Europe, Eastern
36.6(19.0‐67.2)
84.3(43.7‐154.7)
55.1(28.4‐101.2)
0.2(0.0‐0.8)
1.5(0.3‐3.7)
2.5(0.7‐5.8)
2.9(1.0‐6.5)
3.1(0.9‐7.2)
3.6(1.3‐8.4)
5.4(2.2‐10.9)
7.6(3.3‐15.0)
13.5(6.3‐26.3)
28.7(12.8‐56.2)
39.5(18.6‐80.6)
67.6(32.6‐133.3)
106.9(51.1‐205.0)
160.2(77.4‐295.7)
227.5(108.5‐431.8)
328.0(168.4‐621.9)
529.7(259.8‐1,011.0)
Europe, Central
50.0(33.9‐73.9)
115.8(78.4‐171.2)
75.5(51.2‐111.7)
0.2(0.0‐0.6)
1.7(0.7‐3.4)
2.8(1.2‐5.2)
3.2(1.4‐5.9)
3.4(1.5‐6.2)
4.2(1.9‐7.4)
7.4(4.5‐11.5)
9.9(5.8‐15.7)
16.9(10.1‐26.9)
30.9(18.8‐48.8)
49.9(30.2‐81.7)
83.5(52.0‐133.9)
138.2(87.5‐219.2)
214.5(137.4‐334.0)
335.8(216.8‐499.5)
504.0(345.9‐729.0)
757.6(499.9‐1,108.9)
Asia, Central
29.5(18.5‐48.3)
67.0(41.5‐109.0)
44.2(27.5‐71.9)
0.2(0.0‐0.6)
1.6(0.5‐3.4)
2.7(1.2‐5.2)
3.2(1.4‐6.1)
3.4(1.5‐6.4)
3.9(1.9‐7.0)
5.4(3.0‐9.5)
7.3(4.1‐12.6)
12.1(6.8‐20.2)
21.2(12.1‐35.4)
33.8(19.0‐57.5)
58.3(34.7‐97.3)
92.8(54.6‐156.0)
137.0(83.0‐226.3)
184.7(110.2‐321.1)
242.1(147.8‐409.3)
367.7(221.6‐602.4)
Sub‐Saharan Africa, West
43.8(25.9‐72.1)
101.1(59.5‐165.8)
66.0(39.0‐108.4)
0.2(0.0‐0.6)
1.6(0.6‐3.2)
2.7(1.1‐5.5)
3.1(1.4‐5.9)
3.3(1.5‐6.7)
4.0(1.9‐7.5)
6.5(3.6‐11.2)
9.5(5.3‐16.4)
15.9(9.2‐26.8)
28.8(16.6‐48.8)
44.9(25.4‐77.5)
76.4(43.1‐128.8)
125.1(70.1‐218.0)
195.5(110.5‐332.4)
293.3(169.3‐493.2)
417.3(241.8‐705.1)
626.4(349.8‐1,132.5)
Sub‐Saharan Africa, Southern
59.0(37.8‐95.6)
136.6(87.7‐220.7)
89.2(57.2‐144.3)
0.2(0.0‐0.9)
1.7(0.4‐4.1)
2.8(0.8‐6.5)
3.3(1.2‐6.9)
3.5(1.2‐7.7)
4.4(1.6‐9.2)
10.7(5.5‐19.2)
15.2(8.1‐27.0)
22.0(11.3‐40.3)
38.2(20.8‐70.8)
56.1(29.5‐107.8)
101.7(56.4‐180.2)
159.9(85.0‐281.1)
287.9(166.3‐484.2)
391.6(224.5‐647.3)
552.5(327.1‐908.9)
849.4(501.9‐1,461.7)
Sub‐Saharan Africa, East
39.3(24.9‐58.1)
90.6(57.4‐133.9)
59.2(37.4‐87.5)
0.2(0.0‐0.5)
1.5(0.6‐2.9)
2.5(1.2‐4.6)
2.9(1.4‐5.1)
3.1(1.6‐5.6)
3.7(1.8‐6.5)
5.6(3.2‐9.1)
8.1(4.7‐13.1)
13.9(8.3‐21.7)
25.4(15.2‐40.4)
39.8(24.3‐64.5)
68.1(41.0‐107.4)
112.0(66.6‐177.9)
177.8(105.5‐274.0)
261.9(154.8‐397.2)
368.6(229.0‐567.1)
570.6(347.7‐878.8)
Sub‐Saharan Africa, Central
42.6(23.1‐74.3)
98.2(53.5‐170.8)
64.1(35.0‐111.8)
0.2(0.0‐0.8)
1.6(0.3‐3.8)
2.6(0.8‐5.9)
3.0(0.9‐7.0)
3.4(1.1‐7.1)
3.9(1.3‐8.2)
6.3(2.6‐12.2)
9.2(4.3‐17.8)
15.4(7.4‐29.2)
27.9(13.3‐52.4)
44.2(22.2‐82.2)
75.0(38.5‐138.0)
124.0(59.9‐228.3)
193.4(99.2‐351.3)
288.1(145.0‐537.4)
398.9(215.4‐707.2)
592.5(315.4‐1,043.9)
North Africa / Middle East
53.6(40.0‐72.1)
124.1(92.7‐167.2)
81.2(60.8‐109.1)
0.2(0.0‐0.4)
1.4(0.7‐2.4)
2.3(1.3‐4.0)
2.6(1.4‐4.4)
2.8(1.6‐4.7)
3.4(1.9‐5.5)
12.2(7.9‐18.7)
17.7(12.2‐25.6)
27.2(19.1‐38.0)
53.9(35.3‐82.6)
59.2(41.8‐83.4)
98.6(68.1‐141.2)
160.1(112.5‐229.8) 242.9(170.0‐339.6)
354.0(248.8‐493.5)
493.7(341.5‐691.1)
608.4(420.1‐860.1)
Asia, South
36.8(23.9‐54.4)
85.3(55.1‐127.3)
55.6(36.0‐82.5)
0.2(0.0‐0.7)
1.2(0.3‐2.8)
2.0(0.7‐3.8)
2.3(0.8‐4.5)
2.5(1.0‐4.6)
3.0(1.2‐5.6)
5.2(2.6‐9.0)
7.7(4.2‐12.8)
13.1(7.5‐21.3)
24.2(14.0‐42.0)
36.3(21.8‐55.2)
62.3(38.0‐102.0)
105.1(65.0‐171.4)
164.2(100.7‐274.1)
253.9(154.0‐475.0)
347.4(210.5‐572.1)
541.7(339.4‐907.9)
Oceania
70.0(37.7‐121.4)
163.6(87.5‐284.7)
106.0(57.0‐184.3)
0.2(0.0‐0.9)
1.7(0.4‐4.3)
2.8(0.8‐6.4)
3.2(1.0‐7.1)
3.2(1.0‐7.1)
3.8(1.3‐8.5)
9.0(3.8‐18.1)
12.8(5.6‐26.7)
23.9(10.2‐50.5)
48.4(20.2‐115.3)
64.7(30.7‐130.4)
118.2(52.9‐254.8)
215.8(93.6‐492.2)
332.1(145.3‐730.0) 495.9(208.9‐1,149.6)
752.3(331.2‐1,642.5)
897.2(470.2‐1,639.8)
Asia, Southeast
33.5(20.0‐53.8)
77.1(46.4‐123.7)
50.4(30.2‐80.8)
0.2(0.0‐0.5)
1.3(0.5‐2.7)
2.2(0.9‐4.2)
2.5(1.1‐4.6)
2.7(1.1‐5.0)
3.2(1.5‐6.2)
5.1(2.6‐9.3)
7.5(4.3‐13.2)
14.7(8.5‐24.3)
25.0(14.4‐43.3)
40.2(23.1‐64.3)
64.0(38.0‐100.7)
98.1(57.5‐161.3)
148.1(85.7‐246.1)
216.6(121.5‐361.2)
292.9(165.4‐477.7)
446.6(250.8‐738.1)
Asia, East
40.2(27.2‐57.3)
93.5(63.0‐134.1)
60.8(41.0‐86.6)
0.2(0.0‐0.9)
1.1(0.0‐2.9)
1.9(0.4‐4.0)
2.2(0.6‐4.5)
2.4(0.6‐4.9)
2.8(0.9‐5.3)
4.9(2.2‐8.9)
7.2(3.7‐12.1)
12.7(7.2‐20.4)
23.8(13.3‐42.5)
33.6(20.3‐50.7)
56.9(34.7‐88.3)
100.6(61.8‐166.1)
161.9(100.3‐274.2)
268.9(152.2‐501.2)
406.7(235.8‐714.0)
734.4(421.2‐1,368.8)
Latin America, Tropical
52.5(40.3‐67.3)
122.3(94.2‐156.2)
79.5(61.1‐101.6)
0.2(0.0‐0.9)
1.4(0.1‐3.3)
2.3(0.6‐4.7)
2.7(0.8‐5.4)
3.0(0.9‐6.1)
3.7(1.3‐7.0)
6.5(3.6‐10.7)
11.2(6.6‐17.2)
18.8(11.6‐29.3)
33.7(21.7‐48.9)
52.3(34.2‐76.5)
89.0(59.8‐131.4)
144.8(96.6‐209.9)
225.4(156.7‐307.0)
358.3(248.0‐501.6)
514.9(358.2‐716.3)
Latin America, Central
42.8(26.4‐71.0)
98.9(61.2‐164.0)
64.5(39.9‐106.9)
0.2(0.0‐0.7)
1.6(0.5‐3.4)
2.6(1.1‐5.4)
3.0(1.2‐6.2)
3.2(1.3‐6.1)
3.8(1.6‐7.5)
6.0(3.2‐10.6)
9.2(5.0‐15.6)
15.6(8.7‐26.5)
28.3(16.1‐47.4)
46.0(25.9‐78.7)
73.3(41.8‐126.5)
122.5(72.4‐202.3)
190.3(113.4‐311.5)
279.4(166.4‐466.8)
403.8(243.9‐679.1)
626.8(371.7‐1,048.4)
Latin America, Andean
45.3(26.0‐78.7)
104.6(60.2‐181.0)
68.3(39.3‐118.4)
0.2(0.0‐0.8)
1.7(0.4‐3.8)
2.7(1.0‐5.8)
3.2(1.1‐6.9)
3.4(1.1‐7.4)
4.2(1.7‐8.6)
7.1(3.6‐13.4)
11.2(6.3‐19.5)
18.5(10.3‐32.8)
31.0(16.7‐56.7)
51.2(28.6‐91.6)
79.3(42.9‐143.9)
126.9(65.6‐228.3)
191.1(102.6‐342.4)
293.1(160.4‐517.1)
434.1(250.5‐739.9)
651.0(369.1‐1,129.0)
Caribbean
59.4(40.8‐90.0)
137.3(94.3‐207.4)
89.8(61.9‐136.0)
0.2(0.0‐0.7)
1.7(0.6‐3.6)
2.9(1.3‐5.3)
3.3(1.6‐6.3)
3.6(1.7‐6.6)
4.4(2.1‐7.8)
12.4(6.7‐23.3)
18.5(10.7‐30.5)
45.6(24.5‐81.0)
48.7(27.3‐88.4)
66.5(39.8‐107.0)
104.6(63.9‐170.3)
189.4(118.2‐300.0) 244.1(150.7‐404.5)
410.4(255.8‐643.0)
521.1(337.0‐789.0)
680.6(432.1‐1,039.9)
Developed
51.0(39.8‐63.7)
119.0(93.2‐148.2)
77.2(60.3‐96.3)
0.2(0.1‐0.5)
1.5(0.8‐2.4)
2.4(1.4‐3.8)
2.7(1.6‐4.3)
2.9(1.7‐4.5)
3.5(2.1‐5.3)
5.5(3.7‐7.7)
8.0(5.5‐11.1)
14.0(9.7‐19.2)
25.8(18.0‐35.5)
41.6(28.8‐57.2)
70.9(50.1‐96.1)
117.9(84.2‐155.8)
314.2(236.8‐404.1)
530.8(422.0‐663.5)
1,050.8(838.2‐1,316.8)
Developing
41.1(30.5‐54.4)
95.1(70.6‐125.8)
62.0(46.0‐82.1)
0.2(0.1‐0.4)
1.4(0.8‐2.2)
2.2(1.3‐3.4)
2.5(1.5‐3.8)
2.7(1.7‐4.1)
3.3(2.1‐4.9)
6.1(4.2‐8.5)
8.8(6.2‐12.0)
15.1(11.0‐20.5)
27.7(19.3‐39.1)
40.0(28.3‐54.9)
66.5(46.5‐91.2)
112.1(80.2‐155.0)
175.8(125.6‐239.6)
273.2(191.6‐390.3)
392.9(273.1‐550.4)
644.6(457.8‐935.9)
Global
45.9(35.7‐58.5)
106.8(82.9‐135.8)
69.4(53.9‐88.4)
0.2(0.1‐0.4)
1.4(0.8‐2.2)
2.2(1.4‐3.3)
2.6(1.6‐3.8)
2.8(1.7‐4.1)
3.3(2.1‐4.9)
6.0(4.2‐8.3)
8.7(6.2‐11.7)
14.9(10.9‐19.9)
27.2(19.5‐37.6)
40.4(28.5‐55.0)
67.7(48.3‐91.6)
114.0(83.0‐152.9)
182.1(134.9‐238.4)
288.9(214.8‐378.0)
450.4(346.9‐571.4)
867.7(683.2‐1,083.3)
194.8(145.3‐250.8)
806.3(554.3‐1,188.2)
Supplemental Table 5b. Estimated age-standardized DALYs associated with Atrial Fibrillation with 95% Uncertainty Intervals (per
100,000) for all 21 GBD regions for males and females: 1990.
GBD Region
Males
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
North America, High Income
73.6(51.6‐99.9)
170.2(119.2‐230.5)
111.0(77.7‐150.4)
0.4(0.0‐1.3)
2.7(0.9‐5.2)
4.3(1.8‐8.0)
5.0(2.0‐8.7)
Latin America, Southern
72.7(40.0‐127.5)
168.4(93.4‐293.9)
109.8(60.6‐192.0)
0.3(0.0‐1.1)
2.4(0.6‐5.3)
4.0(1.3‐8.5)
4.7(1.6‐9.8)
Europe, Western
64.0(48.2‐84.4)
148.7(112.5‐195.0)
96.7(72.9‐127.2)
0.3(0.1‐0.6)
2.1(1.1‐3.6)
3.5(2.1‐5.4)
4.0(2.4‐6.2)
4.2(2.4‐6.4)
4.9(3.0‐7.6)
8.0(5.4‐11.5)
Australasia
74.5(54.0‐100.1)
172.7(125.4‐231.6)
112.5(81.5‐150.9)
0.3(0.0‐1.1)
2.5(0.8‐5.0)
4.0(1.6‐7.4)
4.6(2.1‐8.3)
5.1(2.2‐8.9)
6.3(3.1‐10.8)
9.7(5.5‐15.8)
Asia Pacific, High Income
46.2(35.2‐59.8)
108.0(82.4‐140.2)
70.0(53.3‐90.6)
0.2(0.0‐0.7)
1.1(0.2‐2.5)
1.8(0.6‐3.6)
2.1(0.7‐4.1)
2.3(0.9‐4.4)
2.9(1.3‐5.3)
5.2(3.1‐8.0)
Europe, Eastern
50.2(25.9‐90.2)
114.4(58.9‐205.7)
75.2(38.8‐135.0)
0.4(0.0‐1.2)
2.5(0.7‐6.2)
4.2(1.5‐9.2)
4.8(1.7‐10.2)
5.1(1.9‐10.5)
6.1(2.4‐12.3)
8.4(3.6‐16.5)
Europe, Central
73.3(47.5‐109.1)
169.5(110.1‐251.6)
110.6(71.7‐164.3)
0.4(0.1‐0.9)
2.6(1.1‐5.1)
4.3(2.1‐7.7)
5.0(2.4‐8.7)
5.4(2.8‐9.6)
6.5(3.5‐11.3)
10.2(5.8‐16.5)
Asia, Central
49.2(29.8‐80.7)
112.2(68.0‐183.6)
73.8(44.7‐120.9)
0.3(0.0‐0.8)
2.4(1.0‐5.0)
4.0(1.9‐7.2)
4.6(2.3‐8.3)
5.0(2.3‐9.1)
5.8(2.9‐10.6)
9.1(5.2‐15.6)
Sub‐Saharan Africa, West
47.4(26.6‐82.4)
108.0(60.3‐188.5)
71.0(39.7‐123.4)
0.3(0.1‐0.9)
2.4(0.9‐5.0)
4.0(1.7‐7.8)
4.7(2.2‐9.1)
5.1(2.3‐9.6)
5.9(2.7‐11.3)
8.0(4.2‐14.8)
Sub‐Saharan Africa, Southern
67.4(36.2‐117.6)
155.4(83.7‐270.8)
101.5(54.6‐177.1)
0.3(0.0‐1.2)
2.5(0.7‐5.7)
4.1(1.4‐8.6)
4.8(1.7‐10.4)
5.3(1.8‐11.7)
6.2(2.4‐13.4)
9.6(4.0‐18.7)
Sub‐Saharan Africa, East
51.6(30.7‐78.2)
118.1(69.4‐178.4)
77.5(45.8‐116.9)
0.3(0.1‐0.7)
2.4(1.0‐4.3)
4.0(2.0‐6.9)
4.7(2.5‐8.1)
5.0(2.6‐8.7)
5.9(3.2‐9.6)
8.5(4.8‐13.5)
Sub‐Saharan Africa, Central
52.7(25.6‐99.9)
120.4(58.6‐228.4)
79.0(38.4‐150.4)
0.3(0.0‐1.2)
2.4(0.6‐5.8)
4.1(1.3‐9.2)
4.8(1.7‐10.4)
5.2(1.8‐11.5)
6.0(2.2‐12.6)
8.5(3.7‐16.8)
North Africa / Middle East
72.5(46.5‐109.1)
166.9(107.0‐251.8)
109.5(70.2‐165.0)
0.3(0.1‐0.7)
2.2(1.1‐4.0)
3.6(1.9‐6.0)
4.2(2.4‐7.0)
4.6(2.6‐7.7)
5.6(3.1‐9.1)
17.1(8.6‐33.2)
Asia, South
43.2(28.5‐62.0)
99.1(65.2‐143.1)
64.9(42.8‐93.3)
0.3(0.0‐0.9)
2.0(0.6‐4.1)
3.2(1.3‐6.1)
3.6(1.6‐6.6)
3.9(1.7‐7.2)
4.7(2.3‐7.9)
6.7(3.6‐11.1)
Oceania
63.9(35.5‐104.4)
147.6(81.9‐242.4)
96.4(53.7‐157.7)
0.3(0.0‐0.9)
2.1(0.6‐5.0)
3.5(1.1‐7.8)
4.1(1.5‐9.0)
4.6(1.6‐10.0)
5.7(2.3‐12.1)
Asia, Southeast
44.6(26.3‐71.7)
101.9(60.5‐164.7)
66.9(39.6‐108.0)
0.3(0.0‐0.7)
2.1(0.9‐4.1)
3.5(1.6‐6.7)
4.0(1.9‐7.4)
4.3(2.1‐7.7)
Asia, East
42.8(29.4‐58.9)
98.5(68.0‐135.7)
64.4(44.4‐88.9)
0.2(0.0‐1.0)
1.7(0.3‐3.8)
2.8(0.9‐5.7)
3.4(1.2‐6.6)
3.6(1.4‐6.8)
Latin America, Tropical
61.2(44.6‐80.2)
141.3(103.0‐185.2)
92.3(67.3‐120.5)
0.3(0.0‐1.3)
2.3(0.5‐4.9)
3.7(1.3‐7.6)
4.2(1.6‐7.9)
4.6(1.8‐8.7)
Latin America, Central
58.6(32.4‐102.4)
133.9(74.2‐232.8)
88.0(48.8‐153.5)
0.4(0.0‐1.0)
2.8(1.0‐6.0)
4.6(1.8‐9.3)
5.4(2.3‐10.9)
5.8(2.5‐11.1)
Latin America, Andean
60.6(32.9‐105.5)
139.0(76.1‐241.9)
91.1(49.7‐158.6)
0.4(0.0‐1.1)
2.6(0.7‐5.6)
4.2(1.6‐8.5)
4.9(1.9‐10.0)
Caribbean
73.0(43.3‐117.1)
167.8(99.3‐269.4)
110.0(65.4‐176.8)
0.4(0.0‐0.9)
2.7(1.0‐5.4)
4.4(2.1‐8.2)
Developed
63.4(47.2‐83.9)
146.6(109.3‐193.4)
95.6(71.2‐126.3)
0.3(0.1‐0.7)
2.3(1.3‐3.5)
Developing
48.2(33.3‐65.6)
110.5(76.3‐150.4)
72.4(49.9‐98.6)
0.3(0.1‐0.6)
2.1(1.2‐3.2)
Global
54.3(39.2‐72.7)
125.2(90.5‐167.1)
81.8(59.1‐109.3)
0.3(0.1‐0.5)
GBD Region
15‐19 years
20‐24 years
25‐29 years
30‐34 years
5.4(2.4‐9.8)
6.9(3.3‐12.0)
10.0(5.6‐15.9)
5.1(1.8‐11.1)
6.2(2.5‐12.6)
9.9(4.8‐19.0)
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
14.9(8.8‐23.2)
26.3(16.6‐38.7)
47.2(30.4‐68.6)
78.4(51.0‐115.3)
130.7(89.2‐192.2)
210.0(141.3‐291.9) 322.3(223.1‐443.2)
481.3(340.4‐652.7)
681.4(486.0‐921.6)
1,104.1(797.9‐1,468.0)
15.4(7.7‐29.0)
26.6(12.7‐48.4)
46.3(23.6‐84.3)
77.9(39.5‐144.0)
131.3(66.1‐239.6)
217.5(117.7‐386.3) 324.6(171.4‐579.5)
471.4(253.8‐851.3)
686.5(375.0‐1,191.4)
1,042.4(559.6‐1,808.7)
11.5(7.9‐16.3)
20.1(13.9‐28.2)
36.1(24.7‐50.0)
61.0(42.5‐84.9)
104.3(73.2‐143.0)
171.1(123.6‐234.6) 281.3(202.3‐373.3)
444.0(329.6‐586.3)
651.6(492.4‐878.8)
1,001.2(745.5‐1,345.2)
13.4(7.8‐21.1)
22.8(14.1‐34.7)
41.5(26.4‐61.2)
69.1(44.7‐104.5)
124.0(84.3‐182.1)
198.5(136.5‐285.1) 324.5(227.8‐452.3)
512.7(353.7‐717.3)
745.1(520.5‐1,027.2)
1,187.0(853.6‐1,596.1)
7.4(4.3‐11.4)
13.7(8.6‐20.1)
25.3(15.8‐36.7)
44.1(30.0‐63.2)
77.1(53.2‐106.7)
127.0(89.9‐174.6)
202.9(144.3‐277.7)
314.9(226.6‐434.8)
468.1(321.1‐646.6)
748.0(531.0‐1,038.1)
11.8(5.2‐22.9)
20.4(10.0‐38.3)
35.9(17.2‐66.3)
59.4(29.2‐112.1)
97.3(49.7‐180.1)
153.6(74.7‐287.7)
221.1(108.3‐405.8)
313.8(156.6‐576.9)
431.5(214.7‐785.8)
654.9(339.3‐1,165.8)
16.6(10.0‐26.8)
27.6(16.6‐42.8)
50.8(31.7‐76.0)
82.8(51.0‐132.1)
134.7(85.0‐205.4)
218.0(134.3‐326.6) 331.7(203.1‐496.3)
481.7(297.1‐725.1)
674.6(419.6‐1,029.1)
997.4(610.7‐1,560.8)
13.8(7.8‐22.8)
20.5(12.0‐33.7)
37.6(22.1‐62.7)
66.7(38.7‐112.6)
100.8(59.3‐167.4)
154.0(88.6‐254.8)
212.5(123.3‐360.5)
298.8(178.9‐484.9)
397.0(230.1‐646.0)
613.7(340.9‐1,001.6)
11.0(5.7‐20.6)
18.5(9.9‐33.7)
32.1(17.3‐58.3)
53.5(28.4‐96.1)
88.1(47.0‐159.1)
140.8(76.9‐248.9)
209.7(114.7‐370.8)
303.3(164.1‐530.8)
416.7(225.0‐727.0)
637.4(346.3‐1,157.7)
14.5(6.5‐28.7)
25.7(11.6‐49.5)
44.6(20.5‐86.5)
73.3(34.8‐143.2)
127.4(62.4‐242.7)
199.2(100.8‐374.4) 296.8(149.0‐538.2)
435.5(222.6‐765.4)
617.5(324.5‐1,060.3)
949.2(514.3‐1,698.4)
12.1(6.7‐19.4)
20.3(11.3‐31.8)
35.8(19.9‐56.9)
59.2(32.8‐93.5)
96.6(55.3‐149.5)
154.0(86.5‐243.1)
229.5(131.8‐361.6)
331.8(193.4‐504.7)
452.9(265.6‐694.2)
692.5(404.8‐1,058.4)
12.0(5.2‐23.0)
20.4(9.1‐39.7)
35.7(15.8‐71.2)
60.1(27.8‐115.3)
98.2(44.8‐188.3)
157.2(73.9‐306.1)
233.6(114.9‐455.9)
339.5(160.9‐648.3)
464.0(220.0‐862.7)
711.9(342.5‐1,357.2)
19.7(11.9‐34.2)
37.1(21.7‐64.3)
58.9(35.5‐94.7)
114.6(59.5‐233.8)
136.7(83.6‐218.9)
223.7(130.4‐386.4) 309.7(194.7‐492.4)
458.2(284.1‐706.9)
599.1(373.8‐923.1)
859.1(534.2‐1,287.5)
9.6(5.3‐15.3)
16.7(9.8‐25.7)
29.6(18.1‐44.5)
49.6(30.3‐76.1)
81.6(52.1‐124.2)
130.6(84.1‐201.8)
193.0(123.1‐283.9)
278.3(175.0‐413.2)
379.7(239.3‐565.6)
583.0(372.8‐855.8)
9.6(4.6‐19.1)
14.5(6.7‐27.6)
24.8(11.9‐46.6)
42.0(20.9‐78.8)
72.1(34.8‐139.2)
116.4(58.9‐215.3)
201.0(100.8‐358.8) 285.1(153.4‐490.5)
426.7(240.1‐725.3)
568.9(319.0‐930.5)
866.3(499.2‐1,403.3)
5.2(2.6‐9.1)
7.4(4.0‐12.7)
10.4(5.9‐18.2)
18.4(10.5‐31.7)
32.6(18.0‐55.3)
54.0(29.5‐92.5)
86.2(47.2‐143.7)
134.4(74.4‐222.6)
197.4(110.5‐327.0)
280.0(163.0‐461.0)
383.2(226.1‐635.2)
582.8(341.9‐920.6)
4.4(1.6‐7.9)
6.4(3.1‐11.1)
9.4(4.8‐15.7)
16.1(9.4‐25.3)
28.3(17.2‐42.5)
46.3(29.0‐67.2)
77.1(50.2‐111.6)
125.8(83.4‐190.4)
190.2(128.1‐277.4)
278.8(182.6‐400.2)
385.8(253.8‐542.9)
611.6(409.0‐863.7)
5.6(2.5‐10.0)
9.0(5.2‐14.7)
13.2(7.6‐20.4)
22.5(14.1‐33.4)
40.8(26.9‐58.3)
69.6(47.1‐99.8)
115.2(77.8‐159.8)
183.7(125.6‐255.9) 278.8(195.0‐380.2)
408.2(285.7‐562.2)
552.2(397.4‐759.3)
824.8(584.7‐1,120.5)
6.8(3.1‐13.3)
10.3(5.5‐18.8)
14.0(7.5‐25.2)
24.0(13.1‐42.8)
40.9(21.6‐72.5)
66.1(34.9‐120.0)
109.3(59.1‐196.9)
173.0(93.6‐311.7)
262.7(143.6‐460.2)
377.9(210.6‐645.3)
514.7(285.5‐891.8)
778.7(424.7‐1,405.6)
5.4(2.1‐10.9)
6.4(2.6‐12.9)
10.2(5.1‐17.9)
15.8(8.6‐27.1)
25.6(13.6‐44.7)
42.2(21.0‐74.8)
70.9(36.7‐124.5)
112.1(58.0‐203.8)
174.0(89.7‐314.5)
265.3(136.1‐465.1)
381.3(199.9‐679.1)
534.6(286.5‐922.5)
840.8(450.6‐1,463.3)
5.2(2.4‐9.6)
5.7(2.8‐10.3)
7.0(3.5‐12.5)
13.9(7.9‐22.1)
17.3(10.1‐28.2)
31.6(18.5‐49.2)
49.6(28.6‐81.6)
85.4(48.9‐135.3)
138.0(78.8‐220.4)
220.1(124.9‐351.1) 321.2(182.6‐521.4)
475.1(277.0‐787.5)
659.8(390.6‐1,098.9)
957.2(532.1‐1,656.8)
3.6(2.2‐5.5)
4.2(2.6‐6.3)
4.5(2.8‐6.8)
5.5(3.4‐8.4)
8.5(5.7‐12.1)
12.4(8.3‐17.4)
21.4(14.6‐29.7)
38.3(26.5‐53.6)
63.6(43.8‐89.0)
107.5(75.6‐146.7)
174.8(125.5‐237.5) 279.7(203.2‐373.0)
427.0(315.0‐562.5)
613.5(462.3‐801.6)
964.3(729.2‐1,257.0)
3.4(2.1‐5.1)
3.9(2.4‐5.8)
4.2(2.6‐6.4)
5.0(3.1‐7.6)
8.0(5.2‐11.4)
11.0(7.3‐15.5)
19.2(12.9‐27.1)
33.3(22.7‐47.3)
56.2(37.6‐78.2)
89.1(60.3‐124.9)
143.6(98.2‐198.8)
212.9(149.0‐290.4)
308.0(210.2‐423.4)
424.9(294.3‐578.1)
657.8(450.6‐893.5)
2.1(1.3‐3.2)
3.5(2.2‐5.1)
4.0(2.5‐5.8)
4.2(2.7‐6.4)
5.1(3.3‐7.7)
8.1(5.4‐11.2)
11.4(7.6‐15.9)
19.9(13.7‐27.5)
34.8(24.2‐48.4)
58.5(40.2‐80.7)
95.0(66.4‐130.6)
154.7(109.8‐208.6) 237.4(171.6‐319.1)
349.8(250.2‐469.4)
506.7(368.1‐662.4)
807.4(598.9‐1,048.2)
Females
35+ years
20+ years
<5 years
5‐9 years
10‐14 years
15‐19 years
20‐24 years
25‐29 years
30‐34 years
35‐39 years
40‐44 years
45‐49 years
50‐54 years
55‐59 years
60‐64 years
65‐69 years
70‐74 years
75‐79 years
80+ years
North America, High Income
45.8(33.1‐61.5)
105.9(77.0‐141.7)
69.1(49.9‐92.6)
0.2(0.0‐1.0)
1.6(0.4‐3.6)
2.6(0.8‐5.4)
3.1(1.2‐6.1)
3.4(1.3‐6.4)
4.2(1.7‐7.4)
6.1(3.0‐10.2)
8.9(5.0‐14.8)
15.6(9.6‐24.5)
27.8(17.8‐40.9)
45.7(29.4‐67.0)
75.0(49.5‐108.4)
120.5(82.2‐170.7)
191.9(136.1‐261.6)
293.1(210.9‐395.8)
447.0(327.1‐591.7)
756.9(552.4‐1,010.0)
Latin America, Southern
46.8(27.2‐80.6)
108.5(63.5‐185.8)
70.6(41.3‐121.3)
0.2(0.0‐0.8)
1.5(0.3‐3.7)
2.5(0.7‐5.8)
2.8(0.9‐6.2)
3.1(1.0‐6.7)
3.8(1.3‐8.2)
5.9(2.5‐11.9)
9.7(4.9‐18.1)
17.0(8.4‐32.1)
29.4(15.2‐54.7)
47.3(22.9‐85.5)
78.8(39.7‐143.7)
129.5(68.2‐241.6)
200.7(104.3‐356.2)
307.8(165.5‐537.3)
462.1(266.5‐797.7)
720.2(408.4‐1,211.1)
Europe, Western
43.0(33.9‐54.6)
99.9(79.3‐126.4)
64.9(51.3‐82.4)
0.2(0.0‐0.5)
1.4(0.7‐2.4)
2.3(1.3‐3.7)
2.6(1.5‐4.2)
2.7(1.6‐4.2)
3.2(1.9‐4.9)
4.9(3.2‐6.9)
7.3(5.0‐10.2)
12.7(8.6‐17.7)
21.8(15.1‐31.2)
35.9(25.1‐50.0)
61.3(44.0‐83.6)
103.3(76.7‐138.1)
169.8(129.7‐225.4)
284.4(222.3‐365.5)
463.3(371.9‐578.9)
792.9(633.7‐1,003.1)
Australasia
50.9(38.4‐68.3)
118.5(89.6‐158.0)
77.0(58.0‐103.1)
0.2(0.0‐0.9)
1.5(0.3‐3.5)
2.5(0.9‐5.1)
2.8(1.0‐5.4)
3.1(1.1‐5.7)
3.8(1.6‐6.8)
6.1(3.1‐10.4)
9.2(4.9‐14.4)
13.7(7.8‐21.6)
26.9(16.9‐41.0)
43.8(27.4‐66.3)
74.2(48.4‐108.1)
125.2(82.5‐179.7)
207.4(141.3‐292.6)
351.5(258.0‐485.5)
529.5(386.4‐706.1)
914.3(657.7‐1,234.5)
Asia Pacific, High Income
28.5(22.4‐35.6)
66.7(52.6‐83.7)
43.2(34.1‐54.0)
0.1(0.0‐0.6)
0.7(0.0‐1.7)
1.1(0.2‐2.4)
1.2(0.3‐2.6)
1.4(0.4‐2.9)
1.6(0.5‐3.4)
3.1(1.6‐4.9)
4.3(2.3‐7.1)
7.7(4.7‐11.8)
14.6(9.5‐21.5)
24.6(16.5‐35.0)
44.4(31.0‐62.1)
72.3(51.1‐98.7)
118.5(86.7‐156.2)
185.5(137.2‐246.3)
297.2(218.2‐391.8)
524.3(373.4‐723.3)
Europe, Eastern
30.6(15.9‐55.3)
69.9(36.1‐126.1)
45.9(23.8‐82.8)
0.2(0.0‐0.8)
1.5(0.3‐3.8)
2.4(0.7‐5.4)
2.8(0.8‐5.9)
3.0(1.0‐6.6)
3.4(1.2‐7.3)
4.8(2.0‐9.9)
6.6(2.8‐13.1)
11.4(5.2‐21.5)
23.3(11.4‐42.6)
33.9(16.2‐60.6)
57.5(29.3‐104.7)
92.2(44.9‐173.8)
134.6(67.4‐248.4)
191.0(93.3‐347.1)
270.2(137.5‐486.6)
416.9(206.6‐756.7)
Europe, Central
40.7(26.3‐63.0)
93.6(60.8‐144.9)
61.3(39.7‐94.8)
0.2(0.0‐0.6)
1.6(0.6‐3.2)
2.6(1.2‐5.0)
3.0(1.4‐5.4)
3.2(1.5‐5.9)
3.8(1.8‐6.7)
6.9(4.1‐11.0)
8.7(5.1‐14.6)
14.6(8.7‐23.8)
25.6(15.0‐40.3)
43.0(25.1‐71.1)
71.4(41.9‐116.0)
117.0(72.2‐185.7)
179.0(113.7‐283.5)
266.5(168.0‐420.8)
382.5(240.9‐595.3)
Asia, Central
29.1(16.8‐47.4)
66.3(38.2‐108.4)
43.6(25.1‐71.0)
0.2(0.0‐0.6)
1.5(0.5‐2.9)
2.4(1.0‐4.6)
2.9(1.3‐5.4)
3.1(1.4‐5.7)
3.6(1.7‐6.6)
5.2(2.9‐8.5)
6.9(3.8‐11.9)
11.6(6.3‐19.9)
21.0(11.3‐35.5)
33.6(17.4‐59.2)
57.9(33.0‐97.9)
92.5(51.8‐158.8)
134.3(77.0‐226.6)
183.6(104.2‐299.0)
243.8(137.7‐407.7)
360.7(203.1‐606.7)
Sub‐Saharan Africa, West
39.8(22.9‐65.3)
91.8(52.8‐151.0)
60.0(34.6‐98.6)
0.2(0.0‐0.7)
1.5(0.6‐3.2)
2.5(1.1‐5.3)
2.9(1.3‐5.7)
3.1(1.4‐6.3)
3.7(1.7‐7.1)
6.0(3.1‐10.5)
8.8(4.7‐15.1)
14.8(8.2‐25.7)
26.4(14.2‐47.0)
42.4(23.1‐75.4)
70.3(39.1‐122.3)
115.4(61.9‐201.0)
175.2(98.0‐302.8)
262.9(144.3‐467.0)
373.9(205.9‐640.8)
567.5(302.4‐1,007.6)
Sub‐Saharan Africa, Southern
56.1(34.6‐93.2)
130.2(80.9‐214.4)
84.8(52.5‐140.0)
0.2(0.0‐0.9)
1.6(0.4‐4.1)
2.7(0.9‐6.5)
3.1(1.0‐7.2)
3.4(1.1‐7.6)
4.1(1.4‐8.8)
8.4(3.4‐16.2)
14.3(6.2‐27.9)
22.5(10.9‐41.9)
37.0(19.2‐66.7)
55.1(28.0‐103.5)
100.6(53.3‐174.5)
150.9(81.7‐278.4)
248.1(135.6‐439.0)
385.2(219.5‐643.3)
532.7(302.8‐910.5)
818.3(461.1‐1,443.4)
Sub‐Saharan Africa, East
39.3(24.3‐60.6)
90.5(55.8‐140.3)
59.1(36.5‐91.4)
0.2(0.0‐0.5)
1.5(0.7‐2.9)
2.5(1.3‐4.5)
2.9(1.5‐5.1)
3.2(1.7‐5.5)
3.7(2.0‐6.2)
5.7(3.2‐9.3)
8.4(4.8‐13.8)
14.3(8.2‐23.2)
25.9(14.8‐42.8)
40.9(23.8‐65.8)
69.4(40.7‐113.6)
114.2(65.9‐186.9)
177.7(105.2‐284.9)
263.4(155.3‐416.3)
364.5(221.9‐573.5)
552.9(341.0‐855.0)
Sub‐Saharan Africa, Central
38.1(20.9‐65.4)
87.7(48.3‐151.4)
57.3(31.6‐98.7)
0.2(0.0‐0.7)
1.5(0.3‐3.7)
2.4(0.7‐5.4)
2.9(1.0‐6.2)
3.1(1.1‐6.6)
3.7(1.3‐7.9)
5.6(2.3‐10.5)
8.3(3.9‐16.1)
13.8(6.4‐25.9)
25.0(11.8‐49.0)
40.0(19.9‐74.7)
67.7(34.4‐124.7)
111.1(54.1‐204.9)
173.0(88.3‐308.6)
251.7(128.5‐456.2)
353.5(188.9‐625.0)
535.8(285.5‐934.4)
North Africa / Middle East
49.4(33.9‐71.9)
114.0(78.5‐166.2)
74.7(51.3‐108.6)
0.2(0.0‐0.4)
1.4(0.6‐2.5)
2.3(1.2‐3.9)
2.6(1.4‐4.3)
2.8(1.5‐4.7)
3.4(1.9‐5.8)
11.2(6.6‐18.7)
16.2(9.7‐25.9)
25.6(14.6‐44.0)
50.4(30.3‐84.7)
54.6(34.4‐83.6)
91.4(56.0‐143.0)
148.2(92.1‐226.3)
221.5(144.7‐329.4)
323.1(210.4‐496.8)
448.3(286.4‐661.8)
560.0(370.1‐833.5)
Asia, South
32.1(21.2‐46.4)
74.0(49.0‐107.6)
48.3(32.0‐70.0)
0.2(0.0‐0.7)
1.2(0.2‐2.7)
1.9(0.7‐3.8)
2.2(0.8‐4.3)
2.4(0.8‐4.6)
2.9(1.1‐5.3)
4.7(2.3‐8.1)
6.8(3.4‐11.6)
11.7(6.8‐19.3)
21.7(12.3‐36.2)
33.6(20.5‐53.9)
56.3(35.4‐86.6)
94.5(58.2‐166.4)
142.7(87.2‐241.6)
215.8(132.6‐371.9)
297.7(182.7‐508.0)
453.1(291.0‐713.3)
Oceania
38.2(20.7‐68.8)
88.2(48.3‐158.6)
57.6(31.3‐103.6)
0.2(0.0‐0.8)
1.4(0.2‐3.5)
2.2(0.6‐5.1)
2.6(0.8‐5.9)
2.8(0.9‐6.2)
3.4(1.2‐7.4)
5.5(2.3‐10.8)
7.7(3.4‐15.6)
13.6(6.3‐26.3)
25.7(11.6‐52.3)
39.7(18.2‐81.1)
68.3(33.0‐130.8)
114.7(54.3‐217.2)
176.3(86.4‐334.8)
255.3(129.2‐471.4)
362.1(182.7‐669.2)
520.5(287.1‐929.9)
Asia, Southeast
28.2(16.3‐47.5)
64.6(37.5‐109.1)
42.4(24.5‐71.5)
0.2(0.0‐0.5)
1.3(0.5‐2.7)
2.1(0.9‐4.2)
2.4(1.0‐4.8)
2.6(1.2‐5.2)
3.1(1.4‐5.8)
4.4(2.4‐8.0)
6.4(3.5‐11.2)
12.2(7.0‐20.4)
21.5(12.0‐37.1)
35.1(19.7‐60.7)
54.6(31.2‐93.2)
83.1(46.4‐142.6)
124.1(69.4‐211.6)
179.0(103.6‐304.8)
240.9(139.1‐413.1)
370.1(211.2‐627.8)
Asia, East
37.4(25.0‐54.0)
86.9(57.9‐125.9)
56.6(37.6‐81.9)
0.2(0.0‐0.9)
1.1(0.0‐2.9)
1.9(0.4‐4.2)
2.3(0.5‐4.8)
2.4(0.5‐5.0)
2.9(0.9‐5.6)
5.1(2.4‐8.5)
7.7(3.7‐13.9)
12.9(7.0‐22.4)
23.5(13.4‐42.3)
34.0(20.8‐53.7)
57.8(35.0‐94.1)
102.0(59.0‐175.5)
160.4(96.5‐274.7)
251.1(147.5‐457.5)
361.9(215.1‐640.3)
615.4(363.2‐1,101.8)
591.1(366.4‐923.2)
Latin America, Tropical
43.2(32.7‐56.5)
100.1(76.0‐130.7)
65.2(49.5‐85.3)
0.2(0.0‐0.9)
1.4(0.0‐3.4)
2.2(0.5‐4.8)
Latin America, Central
39.4(23.8‐64.0)
Latin America, Andean
42.6(24.3‐76.1)
Caribbean
Developed
2.6(0.8‐5.1)
2.8(1.0‐5.7)
3.4(1.2‐6.9)
90.6(55.0‐147.7)
59.3(35.9‐96.5)
0.2(0.0‐0.7)
1.6(0.5‐3.3)
2.7(1.0‐5.3)
3.1(1.2‐6.1)
3.3(1.3‐6.4)
3.9(1.6‐7.2)
98.0(56.2‐175.9)
64.1(36.7‐114.7)
0.2(0.0‐0.8)
1.6(0.4‐3.7)
2.7(0.9‐6.2)
3.1(1.0‐6.5)
3.3(1.1‐7.2)
4.0(1.4‐8.3)
52.4(33.7‐79.7)
120.9(77.9‐183.4)
79.1(50.9‐120.2)
0.2(0.0‐0.7)
1.7(0.6‐3.3)
2.8(1.2‐5.0)
3.2(1.5‐5.9)
3.5(1.6‐6.7)
4.3(2.1‐7.8)
39.6(30.0‐51.8)
91.7(69.8‐119.6)
59.7(45.4‐78.0)
0.2(0.0‐0.5)
1.4(0.8‐2.4)
2.3(1.3‐3.6)
2.6(1.6‐4.0)
2.8(1.7‐4.2)
3.3(2.1‐5.1)
Developing
37.0(26.3‐49.5)
85.6(61.0‐114.6)
55.8(39.7‐74.6)
0.2(0.1‐0.4)
1.3(0.7‐2.1)
2.1(1.3‐3.3)
2.5(1.5‐3.8)
2.6(1.5‐4.1)
Global
38.6(28.9‐50.5)
89.3(67.1‐116.6)
58.2(43.6‐76.2)
0.2(0.1‐0.4)
1.3(0.8‐2.1)
2.1(1.3‐3.3)
2.5(1.5‐3.8)
2.6(1.6‐4.1)
5.6(3.0‐9.4)
8.5(4.7‐13.1)
15.6(9.4‐23.7)
29.5(20.2‐41.8)
47.2(32.2‐66.4)
78.0(53.9‐107.7)
123.5(86.2‐171.0)
196.5(142.2‐265.8)
292.5(214.0‐394.6)
408.3(297.8‐543.9)
602.4(423.5‐813.7)
6.2(3.3‐10.6)
9.4(5.3‐15.8)
16.7(10.1‐27.6)
27.6(15.9‐47.4)
46.4(26.9‐78.0)
7.0(3.3‐12.7)
10.8(5.7‐19.3)
17.4(8.9‐31.8)
29.3(14.4‐55.2)
47.9(24.9‐88.1)
76.0(44.8‐127.9)
120.4(70.2‐201.3)
177.9(104.3‐292.8)
249.9(150.0‐402.2)
345.4(203.0‐556.1)
516.2(295.8‐850.9)
74.8(36.7‐135.6)
121.4(62.5‐224.3)
182.6(95.3‐340.9)
275.1(144.4‐511.0)
390.7(217.4‐690.0)
609.3(335.8‐1,090.1)
9.4(5.2‐15.8)
14.8(8.7‐23.8)
37.3(21.3‐67.2)
41.3(23.2‐72.9)
58.6(33.9‐96.0)
94.1(53.8‐153.6)
162.4(93.7‐269.5)
218.7(129.6‐352.4)
5.2(3.4‐7.6)
7.3(4.9‐10.6)
12.6(8.7‐17.7)
22.7(15.8‐31.3)
36.4(25.1‐50.4)
61.9(43.3‐85.1)
101.7(73.6‐140.3)
162.9(119.7‐220.7)
351.5(208.7‐561.6)
471.7(293.3‐737.2)
625.6(379.0‐1,028.8)
256.8(193.3‐339.3)
397.3(311.2‐512.6)
3.1(1.9‐4.8)
5.6(3.7‐7.9)
8.2(5.5‐11.7)
14.2(9.9‐20.1)
25.5(17.6‐36.6)
37.8(26.2‐52.7)
63.0(44.2‐88.3)
105.3(72.4‐149.1)
161.5(110.3‐229.9)
245.1(168.8‐357.1)
345.5(237.9‐494.3)
684.2(545.7‐851.4)
549.6(380.2‐807.9)
3.2(2.0‐4.8)
5.5(3.7‐7.6)
8.0(5.5‐11.2)
13.7(9.6‐19.0)
24.7(17.5‐34.4)
37.3(26.4‐51.0)
62.6(44.7‐85.8)
103.8(73.8‐140.3)
162.1(117.7‐218.0)
250.1(182.6‐335.7)
372.7(283.3‐486.2)
630.1(495.2‐802.7)
SUPPLEMENTAL FIGURES