Stereological assessment of the epithelial-connective ... oral cancer

Acta Stereologica - Volume 2 (1983) Number 1 - Apr. 1983
Stereological assessment of the epithelial-connective tissue junction in experimental
oral cancer
F.H. White,
Depts. of Anatomy, University of Sheffield, Sheffield S10 2TN, U.K.
K. Gohari,
Cell Biology & Oral Pathology, University of Sheffield, Sheffield S10 2TN, U.K.
Abstract
In the present report, morphological changes at the epithelial-connective tissue junction have been evaluated in carcinomas induced by
the application of DMBA to hamster cheek pouch mucosa. Stereological intersection counting procedures were used to quantify
hemidesmosomes (HD) and lamina densa (LD) in relation to the basal plasma membrane (BM). Parameters characterising both relative
surfaces (S SHD,BM; S SLD,BM) and number/unit surface (NSHD,BM) were significantly reduced in cheek pouch carcinomas when compared
with normal mucosa, whereas individual hemidesmosomal dimensions remained unaffected. Stereological methods can be used to
provide valuable objective information on structural aspects of malignant transformation, and these techniques may be usefully extended
to determine the specificity of these alterations.
Pour citer cet article
F.H. White & K. Gohari, «Stereological assessment of the epithelial-connective tissue junction in experimental oral cancer», Acta Stereologica [En
ligne], Volume 2 (1983), Number 1 - Apr. 1983, 109-117 URL : http://popups.ulg.ac.be/0351-580X/index.php?id=4111.
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